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B0UW58

- ASSY_HISS2

UniProt

B0UW58 - ASSY_HISS2

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441ATPUniRule annotation
Binding sitei100 – 1001CitrullineUniRule annotation
Binding sitei130 – 1301ATP; via amide nitrogenUniRule annotation
Binding sitei132 – 1321AspartateUniRule annotation
Binding sitei132 – 1321ATPUniRule annotation
Binding sitei136 – 1361AspartateUniRule annotation
Binding sitei136 – 1361CitrullineUniRule annotation
Binding sitei137 – 1371AspartateUniRule annotation
Binding sitei137 – 1371ATPUniRule annotation
Binding sitei140 – 1401CitrullineUniRule annotation
Binding sitei193 – 1931CitrullineUniRule annotation
Binding sitei195 – 1951ATPUniRule annotation
Binding sitei202 – 2021CitrullineUniRule annotation
Binding sitei204 – 2041CitrullineUniRule annotation
Binding sitei281 – 2811CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHSOM228400:GHWT-260-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:HSM_0253
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000008543: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Argininosuccinate synthasePRO_1000082401Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi228400.HSM_0253.

Structurei

3D structure databases

ProteinModelPortaliB0UW58.
SMRiB0UW58. Positions 4-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230094.
KOiK01940.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di1.10.287.400. 1 hit.
3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00581. Arg_succ_synth_type2.
InterProiIPR023437. Arg_succ_synth_type2_subfam.
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0UW58-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNTILQHLP IGQKVGIAFS GGLDTSAALL WMRQKGAVPY AYTANLGQPD
60 70 80 90 100
EEDYNAIPRK AMEYGAEKAR LIDCRNQLAH EGIAAIQCGA FHISTGGVTY
110 120 130 140 150
FNTTPLGRAV TGTMLVSAMK EDDVNIWGDG STFKGNDIER FYRYGLLTNP
160 170 180 190 200
SLRIYKPWLD NQFIDELGGR QEMSEFLIAN GFDYKMSAEK AYSTDSNMLG
210 220 230 240 250
ATHEAKDLEY LNSGIRIVKP IMGVAFWRDD VTVKAEEVTV GFEDGVPVTL
260 270 280 290 300
NGQSFSSAVE LFLEANRIGG RHGLGMSDQI ENRIIEAKSR GIYEAPGMAL
310 320 330 340 350
LHIAYERLVT AIHNEDTIEQ YRINGLRLGR LLYQGRWFDP QALMLRETAQ
360 370 380 390 400
RWVARAVTGE VTLELRRGND YSILNTVSPN MTYHPERLSM EKVENAPFDP
410 420 430 440
SDRIGQLTMR NLDITDTRDK LGIYTHTGLL TVGKDSMLPQ LDKK
Length:444
Mass (Da):49,607
Last modified:April 8, 2008 - v1
Checksum:iE1009DA7889C0D5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA31880.1.
RefSeqiYP_001783604.1. NC_010519.1.

Genome annotation databases

EnsemblBacteriaiACA31880; ACA31880; HSM_0253.
GeneIDi6108020.
KEGGihsm:HSM_0253.
PATRICi20197503. VBIHaeSom93646_0265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA31880.1 .
RefSeqi YP_001783604.1. NC_010519.1.

3D structure databases

ProteinModelPortali B0UW58.
SMRi B0UW58. Positions 4-442.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228400.HSM_0253.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA31880 ; ACA31880 ; HSM_0253 .
GeneIDi 6108020.
KEGGi hsm:HSM_0253.
PATRICi 20197503. VBIHaeSom93646_0265.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230094.
KOi K01940.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci HSOM228400:GHWT-260-MONOMER.

Family and domain databases

Gene3Di 1.10.287.400. 1 hit.
3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00581. Arg_succ_synth_type2.
InterProi IPR023437. Arg_succ_synth_type2_subfam.
IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR024074. AS_cat/multimer_dom_body.
IPR024073. AS_multimer_C_tail.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2336.

Entry informationi

Entry nameiASSY_HISS2
AccessioniPrimary (citable) accession number: B0UW58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: November 26, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3