B0UUU5 (MUTL_HAES2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein mutL

Gene names

Name:	mutL
Ordered Locus Names:	HSM_1568

Organism

Haemophilus somnus (strain 2336) (Histophilus somni (strain 2336)) [Complete proteome] [HAMAP]

Taxonomic identifier

228400 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length	615 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP MF_00149
Sequence similarities	Belongs to the DNA mismatch repair mutL/hexB family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mismatch repair Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 615	615	DNA mismatch repair protein mutL HAMAP MF_00149		PRO_1000076699

Sequences

	Sequence		Length	Mass (Da)
	B0UUU5 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 199A6082BC5E95B3	FASTA	615	70,177
	10 20 30 40 50 60 MTIKILPPQL ANQIAAGEVV ERPASVVKEL IENSLDAGAT HIQIEIENGG ANLIRIRDNG 70 80 90 100 110 120 IGIAKDELHL ALARHATSKI ASLDDLEMIL SLGFRGEALA SISSVSRLTL TSRTAQQNEA 130 140 150 160 170 180 WQVYAQGRDM ETSITPASHP IGTTVEVANL FFNTPARRKF LRTDKTEFAH IDEVIRRIAL 190 200 210 220 230 240 AKPQVAFTLT HNNKLIHRYK SAVTNEQKIK RIATICGNDF MQNALHIDWK HNDLHLSGWV 250 260 270 280 290 300 IQPQFARHQN DLNYCYINGR MVKDKVITHA IRQAYSEYLS NEKYPAFVLF IDLNPNEVDV 310 320 330 340 350 360 NVHPTKHEVR FHQARLIHDF IYQGMTNALT SEQTNIPIQS EQSNPTKVAE PQGIWNLTTH 370 380 390 400 410 420 NKGNRATAGK NIFAQQPKDY DKKSSQFKPH FAANYSEVTP KKAVQKAYAE LLATHEEKTI 430 440 450 460 470 480 ASSTLPHQFT HNATHISEQK NVLHALALIE NKALLLQQNQ QYFLLSIQAL QHFNIRLQLQ 490 500 510 520 530 540 QSNIAQQTLL IPILLRLNKQ QYQSWQQQAL FFQQSGFDFT DNSAQRRITL NRLPICLRTQ 550 560 570 580 590 600 NIQKIILQLL DQPHEKYTIF LTALCSHLEF PSLSTFSEAV NLLTKTEQQF STQHQLEFQS 610 LLVKIEWDHY LDKLQ

References

[1]

"Complete sequence of Haemophilus somnus 2336." US DOE Joint Genome Institute Siddaramappa S., Duncan A.J., Challacombe J.F., Rainey D., Gillaspy A.F., Carson M., Gipson J., Gipson M., Bruce D., Detter J.C., Han C.S., Land M., Tapia R., Thompson L.S., Orvis J., Zaitshik J., Barnes G., Brettin T.S., Dyer D.W., Inzana T.J. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 2336.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000947 Genomic DNA. Translation: ACA31327.1.
RefSeq	YP_001784888.1. NC_010519.1.
3D structure databases
ProteinModelPortal	B0UUU5.
SMR	B0UUU5. Positions 1-329.
ModBase	Search...
Protein-protein interaction databases
STRING	B0UUU5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6107464.
GenomeReviews	Gene locus HSM_1568 in contig CP000947_GR.
KEGG	hsm:HSM_1568.
PATRIC	20200374. VBIHaeSom93646_1651.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG520262.
OMA	EVANLFF.
ProtClustDB	PRK00095.
Enzyme and pathway databases
BioCyc	HSOM228400:HSM_1568-MONOMER.
Family and domain databases
HAMAP	MF_00149. DNA_mis_repair. [Tree]
InterPro	IPR003594. ATPase-like_ATP-bd. IPR002099. DNA_mismatch_repair. IPR013507. DNA_mismatch_repair_C. IPR014762. DNA_mismatch_repair_CS. IPR020667. DNA_mismatch_repair_MutL. IPR014763. DNA_mismatch_repair_N. IPR014790. MutL_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K03572.
PANTHER	PTHR10073. DNA_mis_repair. 1 hit.
Pfam	PF01119. DNA_mis_repair. 1 hit. PF02518. HATPase_c. 1 hit. PF08676. MutL_C. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. SM00853. MutL_C. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00585. Mutl. 1 hit.
PROSITE	PS00058. DNA_MISMATCH_REPAIR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTL_HAES2

Accession

Primary (citable) accession number: B0UUU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program