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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei545 – 5451UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciHSOM228400:GHWT-1507-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:HSM_1472
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000008543 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 879879Phosphoenolpyruvate carboxylasePRO_1000082427Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228400.HSM_1472.

Structurei

3D structure databases

ProteinModelPortaliB0UUJ3.
SMRiB0UUJ3. Positions 4-879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
KOiK01595.
OMAiNLMIASL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0UUJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQKYSTLKN NINMLGHFLG ETISDAQGSD ILDLIENIRV LSRDSRSGDE
60 70 80 90 100
KAREKLLDTL STISNENIIP VARAFSQFLN LTNIAEQYQT ISRKHIDQVA
110 120 130 140 150
SDRSLEALFE RLKAQNVPAE KVISTVEKLL IELVLTAHPT EVTRRSLLHK
160 170 180 190 200
YVEINRCLSR LEHDDLTQSE STKLKRRLMQ LIALAWHTNE IRTQRPTPVD
210 220 230 240 250
EAKWGIAVIE NSLWKAVPDF CRQLNLHLEK NFGVQHSVNL APVKFSSWIG
260 270 280 290 300
GDRDGNPFVT AETTRQVLIM NRWKAAELFL ADIQVLSEEL SVVHCTEEFR
310 320 330 340 350
AKYGDHLEPY RVVVKNLRAK LVKTVAYYGE ILENKPSTIN TNDILTDDQQ
360 370 380 390 400
LWEPLYDCYQ SLHQCGMRII ANGILLDCLR RIRCFGLSLS HLDIRQESLR
410 420 430 440 450
HTKALSEITR YIGLGDYSQW MEDDKQAFLI RELSSRRPLL PRNWTPSPET
460 470 480 490 500
QEILETCRVI AQQPEGVISC YIISMARTAS DVLAVHLLLK EAGVTYYLPV
510 520 530 540 550
VPLFETLDDL NASKEVMTQL FNVGWYRGVI NNKQMVMIGY SDSAKDAGMM
560 570 580 590 600
AASWAQYRAQ EQLVNLCEKM GVELTLFHGR GGTIGRGGAP AHAALLSQPP
610 620 630 640 650
RSLKNGLRVT EQGEMIRFKL GLPAVAVNSF DLYASAILEA NLLPPPEPKE
660 670 680 690 700
SWRAIMNELS DSSCNIYRSV VRGDKDFVPY FRSATPEQEL SKLPLGSRPS
710 720 730 740 750
KRNPNGGVES LRAIPWIFAW MQNRLMLPAW LGASASIRQS IEKGNKETIE
760 770 780 790 800
EMCKNWPFFS TRIGMLEMVF SKTDTWLSEH YDLNLVKKEL WYLGQSLREQ
810 820 830 840 850
LQADIKTILS LSHEDELMSD LPWIAESIAL RNIYTDPLNL LQVELLRRLR
860 870
ENPENPNPDV EQALMITITG IAAGMRNTG
Length:879
Mass (Da):99,884
Last modified:April 8, 2008 - v1
Checksum:i5D6A8CD1A0653EC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA31221.1.
RefSeqiWP_012340613.1. NC_010519.1.
YP_001784792.1. NC_010519.1.

Genome annotation databases

EnsemblBacteriaiACA31221; ACA31221; HSM_1472.
KEGGihsm:HSM_1472.
PATRICi20200162. VBIHaeSom93646_1550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA31221.1.
RefSeqiWP_012340613.1. NC_010519.1.
YP_001784792.1. NC_010519.1.

3D structure databases

ProteinModelPortaliB0UUJ3.
SMRiB0UUJ3. Positions 4-879.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi228400.HSM_1472.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA31221; ACA31221; HSM_1472.
KEGGihsm:HSM_1472.
PATRICi20200162. VBIHaeSom93646_1550.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
KOiK01595.
OMAiNLMIASL.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciHSOM228400:GHWT-1507-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2336.

Entry informationi

Entry nameiCAPP_HISS2
AccessioniPrimary (citable) accession number: B0UUJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: April 29, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.