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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei355Proton donorUniRule annotation1
Active sitei387UniRule annotation1
Active sitei515UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciHSOM228400:G1GB8-1475-MONOMER
UniPathwayiUPA00109; UER00181
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:HSM_1413
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
Proteomesi
  • UP000008543 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000812401 – 549Glucose-6-phosphate isomeraseAdd BLAST549

Proteomic databases

PRIDEiB0UUD4

Structurei

3D structure databases

ProteinModelPortaliB0UUD4
SMRiB0UUD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261371
KOiK01810
OMAiTNSQHAF
OrthoDBiPOG091H04C3

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

B0UUD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNINPTQTN AWKALEQHQK DLEQVTIQQL FEQEPTRFND YSLKFAEQIL
60 70 80 90 100
VDYSKNNINQ QTLSLLRQLA KECALNEATE SMFNGEKINR TENRAVLHTA
110 120 130 140 150
LRNCANTPVY VDGKDVMPEV NAVLAKMKSF CQRVISGDWK GYTGKAITDV
160 170 180 190 200
VNIGIGGSDL GPYMVTEALR PYKNHLTMHF VSNVDGTHIA ETLKKVNPET
210 220 230 240 250
TLFLVASKTF TTQETMTNAI SARKWFLAAA QDESQIAKHF AALSTNVKEV
260 270 280 290 300
EKFGIDTHNM FEFWDWVGGR YSLWSAIGLS IALSIGFDNF EQLLAGAHEM
310 320 330 340 350
DKHFRTAPME QNIPITLALI GIWNCNFLGA ETEAMLPYDQ YLHRFAAYFQ
360 370 380 390 400
QGNMESNGKY VDRSGQVINN YQTGPIIWGE PGTNGQHAFY QLIHQGTKII
410 420 430 440 450
PCDFIAPAQT HNVLSDHHNK LLSNFFAQTE ALAFGKTQQE VEAEFIQAGK
460 470 480 490 500
SLDEVKNIVP FKIFTGNKPT NSILVQKITP FTLGALIAMY EHKIFVQGVI
510 520 530 540
FNIYSFDQWG VELGKQLANR ILPELVGDEQ INSHDSSTNG LINQFKSWR
Length:549
Mass (Da):61,893
Last modified:April 8, 2008 - v1
Checksum:i2EA790CC13DC39F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA Translation: ACA31156.1
RefSeqiWP_012340561.1, NC_010519.1

Genome annotation databases

EnsemblBacteriaiACA31156; ACA31156; HSM_1413
GeneIDi31487711
KEGGihsm:HSM_1413

Similar proteinsi

Entry informationi

Entry nameiG6PI_HISS2
AccessioniPrimary (citable) accession number: B0UUD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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