Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B0UTJ5

- PNP_HISS2

UniProt

B0UTJ5 - PNP_HISS2

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi485 – 4851MagnesiumUniRule annotation
    Metal bindingi491 – 4911MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciHSOM228400:GHWT-1149-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:HSM_1114
    OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
    Taxonomic identifieri228400 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
    ProteomesiUP000008543: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 713713Polyribonucleotide nucleotidyltransferasePRO_1000087990Add
    BLAST

    Proteomic databases

    PRIDEiB0UTJ5.

    Interactioni

    Subunit structurei

    Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.UniRule annotation

    Protein-protein interaction databases

    STRINGi228400.HSM_1114.

    Structurei

    3D structure databases

    ProteinModelPortaliB0UTJ5.
    SMRiB0UTJ5. Positions 616-690.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini552 – 61160KHUniRule annotationAdd
    BLAST
    Domaini621 – 68969S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0UTJ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPIVKQFKY GQHTVTLETG AIARQATAAV MASMDDTSVF VTVVAKKDVK    50
    EGQDFFPLTV NYQERTYAAG RIPGGFFKRE GRPSEGETLI ARLIDRPIRP 100
    LFPEGFFNEI QIIATVVSVN PQISPDLVAM IGASAALSLS GVPFNGPIGA 150
    ARVGFINDQF VLNPTMNEQK QSRLDLVVAG TDKAVLMVES EADILTEEQM 200
    LAAVVFGHQQ QQIVIEAIKE FAAEAGKPRW DWTAPEANTI LIEKVKSIAE 250
    NRLGDAYRIT EKQARYEQID LIKADVITQV TAEDETISEG KIIDIFTALE 300
    SQIVRGRILR GEPRIDGRTV DTVRALDICT GVLPRTHGSA IFTRGETQAL 350
    AVATLGTERD AQIIDELTGE KTDHFLFHYN FPPYSVGETG MIGSPKRREI 400
    GHGRLAKRGV AAVMPSLSEF PYVVRVVSEI TESNGSSSMA SVCGASLALM 450
    DAGVPIKAAV AGIAMGLVKE EDNFVVLSDI LGDEDHLGDM DFKVAGTREG 500
    VTALQMDIKI EGITAEIMQI ALNQAKSARM HILGVMEQAI PAPRADISDF 550
    APRIYTMKID PKKIKDVIGK GGATVRSLTE ETGTSIDIDD DGTVKIAAVD 600
    KNAVQEVMSR IEDITAEVEV GVVYKGKVTR LADFGAFVAL VGNKEGLVHI 650
    SQIAEERVEK VSDYLAIGQE VIVKVLEIDR QGRIRLTMKE LAKDQTKNEE 700
    NLLQSEEGSP VQE 713
    Length:713
    Mass (Da):77,535
    Last modified:April 8, 2008 - v1
    Checksum:i9F23D881037D917B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000947 Genomic DNA. Translation: ACA30834.1.
    RefSeqiWP_011608859.1. NC_010519.1.
    YP_001784444.1. NC_010519.1.

    Genome annotation databases

    EnsemblBacteriaiACA30834; ACA30834; HSM_1114.
    GeneIDi6106966.
    KEGGihsm:HSM_1114.
    PATRICi20199415. VBIHaeSom93646_1182.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000947 Genomic DNA. Translation: ACA30834.1 .
    RefSeqi WP_011608859.1. NC_010519.1.
    YP_001784444.1. NC_010519.1.

    3D structure databases

    ProteinModelPortali B0UTJ5.
    SMRi B0UTJ5. Positions 616-690.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 228400.HSM_1114.

    Proteomic databases

    PRIDEi B0UTJ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA30834 ; ACA30834 ; HSM_1114 .
    GeneIDi 6106966.
    KEGGi hsm:HSM_1114.
    PATRICi 20199415. VBIHaeSom93646_1182.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci HSOM228400:GHWT-1149-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2336.

    Entry informationi

    Entry nameiPNP_HISS2
    AccessioniPrimary (citable) accession number: B0UTJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3