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B0UTE6 (AROB_HAES2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:HSM_1065
OrganismHaemophilus somnus (strain 2336) (Histophilus somni (strain 2336)) [Complete proteome] [HAMAP]
Taxonomic identifier228400 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3623623-dehydroquinate synthase HAMAP MF_00110
PRO_1000094529

Sequences

Sequence LengthMass (Da)Tools
B0UTE6 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 67E8245AC2C17932

FASTA36239,735
        10         20         30         40         50         60 
MLCVNVELRE RSYPIHIGMG LLSEPQVYPL KKGDKVMIVT NPTVAQYYLS SITDTLEKIG 

        70         80         90        100        110        120 
CSVENVQLPE GEQYKTLESL DLIFTALLKA NHGRDTSIIA LGGGVIGDIA GYAAASYQRG 

       130        140        150        160        170        180 
VRFIQIPTTL LAQVDSSVGG KTAVNHKLGK NMIGAFYQPC AVIIDTLTLT TLPKREIHAG 

       190        200        210        220        230        240 
LAEVIKYGAI LDDEFFTWLE KHITNLVALE QQYLQQCIAR CCQIKADVVT RDETEKGERA 

       250        260        270        280        290        300 
LLNLGHTFGH AIETHLGYGN WLHGEAVATG MMIAAVLSNK LGDLSLNDVT RLEKLLTQAD 

       310        320        330        340        350        360 
LPTASPDTMK AEDYLPHMMR DKKVLAGKLR LVLLKSLGQA YVATDTDKEY VLDAIRTCSK 


KS

« Hide

References

[1]"Complete sequence of Haemophilus somnus 2336."
US DOE Joint Genome Institute
Siddaramappa S., Duncan A.J., Challacombe J.F., Rainey D., Gillaspy A.F., Carson M., Gipson J., Gipson M., Bruce D., Detter J.C., Han C.S., Land M., Tapia R., Thompson L.S., Orvis J., Zaitshik J., Barnes G., Brettin T.S., Dyer D.W., Inzana T.J.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2336.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000947 Genomic DNA. Translation: ACA30780.1.
RefSeqYP_001784395.1. NC_010519.1.

3D structure databases

ProteinModelPortalB0UTE6.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0UTE6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6106912.
GenomeReviewsGene locus HSM_1065 in contig CP000947_GR.
KEGGhsm:HSM_1065.
PATRIC20199317. VBIHaeSom93646_1133.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG632303.
OMAVMALEMS.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycHSOM228400:HSM_1065-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_HAES2
AccessionPrimary (citable) accession number: B0UTE6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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