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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62SubstrateUniRule annotation1
Binding sitei70SubstrateUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Sitei175Important for catalytic activityUniRule annotation1
Active sitei177Proton donor/acceptorUniRule annotation1
Active sitei249NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciHSOM228400:G1GB8-1097-MONOMER
UniPathwayiUPA00544

Protein family/group databases

CAZyiGH3 Glycoside Hydrolase Family 3

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotation
Ordered Locus Names:HSM_1045
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
Proteomesi
  • UP000008543 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000795751 – 348Beta-hexosaminidaseAdd BLAST348

Structurei

3D structure databases

ProteinModelPortaliB0UTC6
SMRiB0UTC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 165Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000248526
KOiK01207
OMAiHKETPRD
OrthoDBiPOG091H039J

Family and domain databases

Gene3Di3.20.20.300, 1 hit
HAMAPiMF_00364 NagZ, 1 hit
InterProiView protein in InterPro
IPR022956 Beta_hexosaminidase_bac
IPR001764 Glyco_hydro_3_N
IPR036962 Glyco_hydro_3_N_sf
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF00933 Glyco_hydro_3, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

B0UTC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILLIDLSG QELRQEEIEL LEHPLVAGLI LFSRNFYDIE QIRHLIRSVR
60 70 80 90 100
QKVKKPLLIT VDQEGGRVQR FRQGLTQLPA MQSFACLLSD PQEQQEMAWR
110 120 130 140 150
AGWQMAAEMT ALDIDLSFAP VLDLGHQCKA IGDRSFHYEE KKLIELAEKF
160 170 180 190 200
IQGMRQIGMS ATGKHFPGHG HVLADSHLET PYDDRAKELI FAQDIRPFQS
210 220 230 240 250
LIKQGLLDAV MPAHVIYTQC DNQPASGSSY WLKEVLRQQL GFQGAIFSDD
260 270 280 290 300
LGMKGAGFMG DFVARCTQSL QAGCDLLLLC NEPEAVVQVL DRFKPQESQN
310 320 330 340
KRIIRQTRLN KLFKKQRIDW QTLRTQRDWL ENHKKLTALQ QDWLAYKG
Length:348
Mass (Da):39,887
Last modified:April 8, 2008 - v1
Checksum:iD7636FC113199C34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA Translation: ACA30759.1
RefSeqiWP_012340236.1, NC_010519.1

Genome annotation databases

EnsemblBacteriaiACA30759; ACA30759; HSM_1045
GeneIDi31487344
KEGGihsm:HSM_1045

Similar proteinsi

Entry informationi

Entry nameiNAGZ_HISS2
AccessioniPrimary (citable) accession number: B0UTC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: February 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health