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B0UTC6

- NAGZ_HISS2

UniProt

B0UTC6 - NAGZ_HISS2

Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei62 – 621SubstrateUniRule annotation
    Binding sitei70 – 701SubstrateUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Sitei175 – 1751Important for catalytic activityUniRule annotation
    Active sitei177 – 1771Proton donor/acceptorUniRule annotation
    Active sitei249 – 2491NucleophileUniRule annotation

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell cycle Source: UniProtKB-KW
    3. cell division Source: UniProtKB-KW
    4. peptidoglycan biosynthetic process Source: UniProtKB-KW
    5. peptidoglycan turnover Source: UniProtKB-HAMAP
    6. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciHSOM228400:GHWT-1080-MONOMER.
    UniPathwayiUPA00544.

    Protein family/group databases

    CAZyiGH3. Glycoside Hydrolase Family 3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
    Alternative name(s):
    Beta-N-acetylhexosaminidaseUniRule annotation
    N-acetyl-beta-glucosaminidaseUniRule annotation
    Gene namesi
    Name:nagZUniRule annotation
    Ordered Locus Names:HSM_1045
    OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
    Taxonomic identifieri228400 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
    ProteomesiUP000008543: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Beta-hexosaminidasePRO_1000079575Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi228400.HSM_1045.

    Structurei

    3D structure databases

    ProteinModelPortaliB0UTC6.
    SMRiB0UTC6. Positions 2-301.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni164 – 1652Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1472.
    HOGENOMiHOG000248526.
    KOiK01207.
    OrthoDBiEOG6BCT06.

    Family and domain databases

    Gene3Di3.20.20.300. 1 hit.
    HAMAPiMF_00364. NagZ.
    InterProiIPR022956. Beta_hexosaminidase_bac.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00933. Glyco_hydro_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0UTC6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSILLIDLSG QELRQEEIEL LEHPLVAGLI LFSRNFYDIE QIRHLIRSVR    50
    QKVKKPLLIT VDQEGGRVQR FRQGLTQLPA MQSFACLLSD PQEQQEMAWR 100
    AGWQMAAEMT ALDIDLSFAP VLDLGHQCKA IGDRSFHYEE KKLIELAEKF 150
    IQGMRQIGMS ATGKHFPGHG HVLADSHLET PYDDRAKELI FAQDIRPFQS 200
    LIKQGLLDAV MPAHVIYTQC DNQPASGSSY WLKEVLRQQL GFQGAIFSDD 250
    LGMKGAGFMG DFVARCTQSL QAGCDLLLLC NEPEAVVQVL DRFKPQESQN 300
    KRIIRQTRLN KLFKKQRIDW QTLRTQRDWL ENHKKLTALQ QDWLAYKG 348
    Length:348
    Mass (Da):39,887
    Last modified:April 8, 2008 - v1
    Checksum:iD7636FC113199C34
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000947 Genomic DNA. Translation: ACA30759.1.
    RefSeqiYP_001784375.1. NC_010519.1.

    Genome annotation databases

    EnsemblBacteriaiACA30759; ACA30759; HSM_1045.
    GeneIDi6106890.
    KEGGihsm:HSM_1045.
    PATRICi20199275. VBIHaeSom93646_1112.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000947 Genomic DNA. Translation: ACA30759.1 .
    RefSeqi YP_001784375.1. NC_010519.1.

    3D structure databases

    ProteinModelPortali B0UTC6.
    SMRi B0UTC6. Positions 2-301.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 228400.HSM_1045.

    Protein family/group databases

    CAZyi GH3. Glycoside Hydrolase Family 3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA30759 ; ACA30759 ; HSM_1045 .
    GeneIDi 6106890.
    KEGGi hsm:HSM_1045.
    PATRICi 20199275. VBIHaeSom93646_1112.

    Phylogenomic databases

    eggNOGi COG1472.
    HOGENOMi HOG000248526.
    KOi K01207.
    OrthoDBi EOG6BCT06.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci HSOM228400:GHWT-1080-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.300. 1 hit.
    HAMAPi MF_00364. NagZ.
    InterProi IPR022956. Beta_hexosaminidase_bac.
    IPR001764. Glyco_hydro_3_N.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00933. Glyco_hydro_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2336.

    Entry informationi

    Entry nameiNAGZ_HISS2
    AccessioniPrimary (citable) accession number: B0UTC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3