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Protein

Xylose isomerase

Gene

xylA

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei101 – 1011UniRule annotation
Active sitei104 – 1041UniRule annotation
Metal bindingi232 – 2321Magnesium 1UniRule annotation
Metal bindingi268 – 2681Magnesium 1UniRule annotation
Metal bindingi268 – 2681Magnesium 2UniRule annotation
Metal bindingi271 – 2711Magnesium 2UniRule annotation
Metal bindingi296 – 2961Magnesium 1UniRule annotation
Metal bindingi307 – 3071Magnesium 2UniRule annotation
Metal bindingi309 – 3091Magnesium 2UniRule annotation
Metal bindingi339 – 3391Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciHSOM228400:GHWT-968-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:HSM_0936
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000008543 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Xylose isomerasePRO_1000081030Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi228400.HSM_0936.

Structurei

3D structure databases

ProteinModelPortaliB0UT19.
SMRiB0UT19. Positions 2-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0UT19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNYFDKIAK VNYEGANSTN PFAFKHYNPN EVILGKTVEE HLRLAVCYWH
60 70 80 90 100
TFCWTGNDMF GAGSLDRSWQ KTGDLLVGAK QKAEIAFEFF QKLGVPYYSF
110 120 130 140 150
HDVDIAPESN NFKEYLHNFN TIVDILEKKQ SETGVKLLWG TANCFTNPRY
160 170 180 190 200
MSGASTNPNP EVFAWAAAQV FTAMNATQRL GGENYVLWGG REGYETLLNT
210 220 230 240 250
DLKREREQIG RFMQLVVEHK YKIGFQGTLL IEPKPQEPTK HQYDYDVATV
260 270 280 290 300
YGFLKQFGLE NEIKVNIEAN HATLAGHTFQ HEIATATSLG IFGSIDANRG
310 320 330 340 350
DPQLGWDTDQ FPNSVEENTL AMYEILKAGG FTTGGFNFDA KIRRQSTDPY
360 370 380 390 400
DLFHAHIGAM DVLALSLKRA AKMIEDQTLQ KVVDNRYAGW DQELGQKILS
410 420 430
GKASLEDLAK IVETQGLDPK PVSGQQEYLE NLVNSYLYR
Length:439
Mass (Da):49,604
Last modified:April 8, 2008 - v1
Checksum:i00A850D6B2BF816D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA32619.1.
RefSeqiWP_012341741.1. NC_010519.1.
YP_001784268.1. NC_010519.1.

Genome annotation databases

EnsemblBacteriaiACA32619; ACA32619; HSM_0936.
KEGGihsm:HSM_0936.
PATRICi20199047. VBIHaeSom93646_1001.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA32619.1.
RefSeqiWP_012341741.1. NC_010519.1.
YP_001784268.1. NC_010519.1.

3D structure databases

ProteinModelPortaliB0UT19.
SMRiB0UT19. Positions 2-439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi228400.HSM_0936.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA32619; ACA32619; HSM_0936.
KEGGihsm:HSM_0936.
PATRICi20199047. VBIHaeSom93646_1001.

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiEOG62NX4R.

Enzyme and pathway databases

BioCyciHSOM228400:GHWT-968-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2336.

Entry informationi

Entry nameiXYLA_HISS2
AccessioniPrimary (citable) accession number: B0UT19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: April 29, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.