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B0UT19 (XYLA_HISS2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xylose isomerase

EC=5.3.1.5
Gene names
Name:xylA
Ordered Locus Names:HSM_0936
OrganismHistophilus somni (strain 2336) (Haemophilus somnus) [Complete proteome] [HAMAP]
Taxonomic identifier228400 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-xylopyranose = D-xylulose. HAMAP-Rule MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP-Rule MF_00455

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00455

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00455.

Sequence similarities

Belongs to the xylose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-xylose metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

xylose isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Xylose isomerase HAMAP-Rule MF_00455
PRO_1000081030

Sites

Active site1011 By similarity
Active site1041 By similarity
Metal binding2321Magnesium 1 By similarity
Metal binding2681Magnesium 1 By similarity
Metal binding2681Magnesium 2 By similarity
Metal binding2711Magnesium 2 By similarity
Metal binding2961Magnesium 1 By similarity
Metal binding3071Magnesium 2 By similarity
Metal binding3091Magnesium 2 By similarity
Metal binding3391Magnesium 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
B0UT19 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 00A850D6B2BF816D

FASTA43949,604
        10         20         30         40         50         60 
MSNYFDKIAK VNYEGANSTN PFAFKHYNPN EVILGKTVEE HLRLAVCYWH TFCWTGNDMF 

        70         80         90        100        110        120 
GAGSLDRSWQ KTGDLLVGAK QKAEIAFEFF QKLGVPYYSF HDVDIAPESN NFKEYLHNFN 

       130        140        150        160        170        180 
TIVDILEKKQ SETGVKLLWG TANCFTNPRY MSGASTNPNP EVFAWAAAQV FTAMNATQRL 

       190        200        210        220        230        240 
GGENYVLWGG REGYETLLNT DLKREREQIG RFMQLVVEHK YKIGFQGTLL IEPKPQEPTK 

       250        260        270        280        290        300 
HQYDYDVATV YGFLKQFGLE NEIKVNIEAN HATLAGHTFQ HEIATATSLG IFGSIDANRG 

       310        320        330        340        350        360 
DPQLGWDTDQ FPNSVEENTL AMYEILKAGG FTTGGFNFDA KIRRQSTDPY DLFHAHIGAM 

       370        380        390        400        410        420 
DVLALSLKRA AKMIEDQTLQ KVVDNRYAGW DQELGQKILS GKASLEDLAK IVETQGLDPK 

       430 
PVSGQQEYLE NLVNSYLYR 

« Hide

References

[1]"Complete sequence of Haemophilus somnus 2336."
US DOE Joint Genome Institute
Siddaramappa S., Duncan A.J., Challacombe J.F., Rainey D., Gillaspy A.F., Carson M., Gipson J., Gipson M., Bruce D., Detter J.C., Han C.S., Land M., Tapia R., Thompson L.S., Orvis J., Zaitshik J., Barnes G., Brettin T.S., Dyer D.W., Inzana T.J.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2336.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000947 Genomic DNA. Translation: ACA32619.1.
RefSeqYP_001784268.1. NC_010519.1.

3D structure databases

ProteinModelPortalB0UT19.
SMRB0UT19. Positions 2-439.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING228400.HSM_0936.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA32619; ACA32619; HSM_0936.
GeneID6108768.
KEGGhsm:HSM_0936.
PATRIC20199047. VBIHaeSom93646_1001.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2115.
HOGENOMHOG000252293.
KOK01805.
OrthoDBEOG62NX4R.

Enzyme and pathway databases

BioCycHSOM228400:GHWT-968-MONOMER.

Family and domain databases

Gene3D3.20.20.150. 1 hit.
HAMAPMF_00455. Xylose_isom_A.
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
SUPFAMSSF51658. SSF51658. 1 hit.
TIGRFAMsTIGR02630. xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXYLA_HISS2
AccessionPrimary (citable) accession number: B0UT19
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families