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B0UT19

- XYLA_HISS2

UniProt

B0UT19 - XYLA_HISS2

Protein

Xylose isomerase

Gene

xylA

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.UniRule annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei101 – 1011UniRule annotation
    Active sitei104 – 1041UniRule annotation
    Metal bindingi232 – 2321Magnesium 1UniRule annotation
    Metal bindingi268 – 2681Magnesium 1UniRule annotation
    Metal bindingi268 – 2681Magnesium 2UniRule annotation
    Metal bindingi271 – 2711Magnesium 2UniRule annotation
    Metal bindingi296 – 2961Magnesium 1UniRule annotation
    Metal bindingi307 – 3071Magnesium 2UniRule annotation
    Metal bindingi309 – 3091Magnesium 2UniRule annotation
    Metal bindingi339 – 3391Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shunt, Xylose metabolism

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciHSOM228400:GHWT-968-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
    Gene namesi
    Name:xylAUniRule annotation
    Ordered Locus Names:HSM_0936
    OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
    Taxonomic identifieri228400 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
    ProteomesiUP000008543: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 439439Xylose isomerasePRO_1000081030Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi228400.HSM_0936.

    Structurei

    3D structure databases

    ProteinModelPortaliB0UT19.
    SMRiB0UT19. Positions 2-439.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2115.
    HOGENOMiHOG000252293.
    KOiK01805.
    OrthoDBiEOG62NX4R.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0UT19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNYFDKIAK VNYEGANSTN PFAFKHYNPN EVILGKTVEE HLRLAVCYWH    50
    TFCWTGNDMF GAGSLDRSWQ KTGDLLVGAK QKAEIAFEFF QKLGVPYYSF 100
    HDVDIAPESN NFKEYLHNFN TIVDILEKKQ SETGVKLLWG TANCFTNPRY 150
    MSGASTNPNP EVFAWAAAQV FTAMNATQRL GGENYVLWGG REGYETLLNT 200
    DLKREREQIG RFMQLVVEHK YKIGFQGTLL IEPKPQEPTK HQYDYDVATV 250
    YGFLKQFGLE NEIKVNIEAN HATLAGHTFQ HEIATATSLG IFGSIDANRG 300
    DPQLGWDTDQ FPNSVEENTL AMYEILKAGG FTTGGFNFDA KIRRQSTDPY 350
    DLFHAHIGAM DVLALSLKRA AKMIEDQTLQ KVVDNRYAGW DQELGQKILS 400
    GKASLEDLAK IVETQGLDPK PVSGQQEYLE NLVNSYLYR 439
    Length:439
    Mass (Da):49,604
    Last modified:April 8, 2008 - v1
    Checksum:i00A850D6B2BF816D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000947 Genomic DNA. Translation: ACA32619.1.
    RefSeqiWP_012341741.1. NC_010519.1.
    YP_001784268.1. NC_010519.1.

    Genome annotation databases

    EnsemblBacteriaiACA32619; ACA32619; HSM_0936.
    GeneIDi6108768.
    KEGGihsm:HSM_0936.
    PATRICi20199047. VBIHaeSom93646_1001.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000947 Genomic DNA. Translation: ACA32619.1 .
    RefSeqi WP_012341741.1. NC_010519.1.
    YP_001784268.1. NC_010519.1.

    3D structure databases

    ProteinModelPortali B0UT19.
    SMRi B0UT19. Positions 2-439.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 228400.HSM_0936.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA32619 ; ACA32619 ; HSM_0936 .
    GeneIDi 6108768.
    KEGGi hsm:HSM_0936.
    PATRICi 20199047. VBIHaeSom93646_1001.

    Phylogenomic databases

    eggNOGi COG2115.
    HOGENOMi HOG000252293.
    KOi K01805.
    OrthoDBi EOG62NX4R.

    Enzyme and pathway databases

    BioCyci HSOM228400:GHWT-968-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2336.

    Entry informationi

    Entry nameiXYLA_HISS2
    AccessioniPrimary (citable) accession number: B0UT19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3