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Protein

Lipid A biosynthesis lauroyltransferase

Gene

lpxL

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).UniRule annotation

Catalytic activityi

A dodecanoyl-[acyl-carrier protein] + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IV(A) = (Kdo)(2)-(dodecanoyl)-lipid IV(A) + a holo-[acyl-carrier protein].UniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciHSOM228400:GHWT-956-MONOMER.
UniPathwayiUPA00030.
UPA00360; UER00485.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A biosynthesis lauroyltransferaseUniRule annotation (EC:2.3.1.241UniRule annotation)
Alternative name(s):
Kdo(2)-lipid IV(A) lauroyltransferaseUniRule annotation
Gene namesi
Name:lpxLUniRule annotation
Ordered Locus Names:HSM_0924Imported
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)Imported
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000008543 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Protein-protein interaction databases

STRINGi228400.HSM_0924.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi134 – 1396HXXXXD motifUniRule annotation

Sequence similaritiesi

Belongs to the LpxL/LpxM/LpxP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiCOG1560.
HOGENOMiHOG000265960.
KOiK02517.
OMAiLRSNKAL.
OrthoDBiEOG657J8B.

Family and domain databases

HAMAPiMF_01942. Lipid_A_LpxL_LpxP.
InterProiIPR004960. LipA_acyltrans.
IPR011920. Lipid_A_LpxL_LpxP.
[Graphical view]
PfamiPF03279. Lip_A_acyltrans. 1 hit.
[Graphical view]
PIRSFiPIRSF026649. MsbB. 1 hit.
TIGRFAMsiTIGR02207. lipid_A_htrB. 1 hit.

Sequencei

Sequence statusi: Complete.

B0UT07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKTSIPQFN IEFLKPKYWL FWLGFLFFRL ILLLPYPILL KIGNGLGSLF
60 70 80 90 100
SHLKIGQRRT KIARQNLQLC FPHYSEQEIN DILQSNLKAT GMAIIETGMA
110 120 130 140 150
WFWSDKRIKK WSKIEGLEYL KENQQDGIIL VGIHFLTLEL GARIIGLSHP
160 170 180 190 200
GIGIYRPHDN PLMDWLQCRG RARSNKGLLD RKDLRAMIKA IRHGEMIWYA
210 220 230 240 250
PDHDYGRKNA VFVPFFAVPE AATTTGSYYL IKSSPKSKVI PFTPLRNKDN
260 270 280 290 300
SGYTLNISAP IDFSDILHDE TAIATRMNKI VEKEILQDVT QYMWLHRRFK
310
TRPNEHQQSL YE
Length:312
Mass (Da):36,249
Last modified:April 8, 2008 - v1
Checksum:i9534599E772A9328
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA32606.1.
RefSeqiWP_012341732.1. NC_010519.1.
YP_001784256.1. NC_010519.1.

Genome annotation databases

EnsemblBacteriaiACA32606; ACA32606; HSM_0924.
KEGGihsm:HSM_0924.
PATRICi20199023. VBIHaeSom93646_0989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA32606.1.
RefSeqiWP_012341732.1. NC_010519.1.
YP_001784256.1. NC_010519.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi228400.HSM_0924.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA32606; ACA32606; HSM_0924.
KEGGihsm:HSM_0924.
PATRICi20199023. VBIHaeSom93646_0989.

Phylogenomic databases

eggNOGiCOG1560.
HOGENOMiHOG000265960.
KOiK02517.
OMAiLRSNKAL.
OrthoDBiEOG657J8B.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00360; UER00485.
BioCyciHSOM228400:GHWT-956-MONOMER.

Family and domain databases

HAMAPiMF_01942. Lipid_A_LpxL_LpxP.
InterProiIPR004960. LipA_acyltrans.
IPR011920. Lipid_A_LpxL_LpxP.
[Graphical view]
PfamiPF03279. Lip_A_acyltrans. 1 hit.
[Graphical view]
PIRSFiPIRSF026649. MsbB. 1 hit.
TIGRFAMsiTIGR02207. lipid_A_htrB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2336Imported.

Entry informationi

Entry nameiB0UT07_HISS2
AccessioniPrimary (citable) accession number: B0UT07
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 27, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.