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B0USP2

- CDD_HISS2

UniProt

B0USP2 - CDD_HISS2

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Protein
Cytidine deaminase
Gene
cdd, HSM_0805
Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.UniRule annotation

Catalytic activityi

Cytidine + H2O = uridine + NH3.UniRule annotation
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.UniRule annotation

Cofactori

Binds 1 zinc ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi111 – 1111Zinc; catalytic By similarity
Active sitei113 – 1131Proton donor By similarity
Metal bindingi138 – 1381Zinc; catalytic By similarity
Metal bindingi141 – 1411Zinc; catalytic By similarity

GO - Molecular functioni

  1. cytidine deaminase activity Source: UniProtKB-HAMAP
  2. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciHSOM228400:GHWT-829-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytidine deaminase (EC:3.5.4.5)
    Alternative name(s):
    Cytidine aminohydrolase
    Short name:
    CDA
    Gene namesi
    Name:cdd
    Ordered Locus Names:HSM_0805
    OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
    Taxonomic identifieri228400 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
    ProteomesiUP000008543: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Cytidine deaminaseUniRule annotation
    PRO_1000087794Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi228400.HSM_0805.

    Structurei

    3D structure databases

    ProteinModelPortaliB0USP2.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini69 – 15183CMP/dCMP deaminase zinc-binding
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni98 – 1003Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0295.
    HOGENOMiHOG000218617.
    KOiK01489.
    OrthoDBiEOG6XDH25.

    Family and domain databases

    HAMAPiMF_01558. Cyt_deam.
    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR013171. Cyd/dCyd_deaminase_Zn-bd.
    IPR006263. Cyt_deam_dimer.
    IPR016193. Cytidine_deaminase-like.
    IPR020797. Cytidine_deaminase_bacteria.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    PF08211. dCMP_cyt_deam_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006334. Cdd_plus_pseudo. 1 hit.
    SUPFAMiSSF53927. SSF53927. 2 hits.
    TIGRFAMsiTIGR01355. cyt_deam_dimer. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0USP2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTHHSLKHIS DRIKQALNQI ENRNLAQDLW YILGEQNFQG FLPAFTVNHF    50
    CEKYHMTDKE LALILLPVSA CYANPTISHF SVGAIAKGES GNFYFGANQE 100
    FCTTNIQQTV HAEQSAISHA WMRRESKITE ITVNYTPCGH CRQFMNELNS 150
    AETLRIHLPH SQDNLLHHYL PDAFGPHNLQ IDNRLFDKKA HNLFLITEDP 200
    LIQAALDAAN QSHAPYSKTY SGIALQLQDQ QIFQGSYAEN AAFNPSLPPL 250
    QTALNYLLLN GNEVENIARA VLVEQPFRLS YRGMTEELLA YLGDIPLDYI 300
    QVS 303
    Length:303
    Mass (Da):34,354
    Last modified:April 8, 2008 - v1
    Checksum:i80554A8D43223190
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000947 Genomic DNA. Translation: ACA32478.1.
    RefSeqiWP_012341620.1. NC_010519.1.
    YP_001784141.1. NC_010519.1.

    Genome annotation databases

    EnsemblBacteriaiACA32478; ACA32478; HSM_0805.
    GeneIDi6108625.
    KEGGihsm:HSM_0805.
    PATRICi20198731. VBIHaeSom93646_0853.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000947 Genomic DNA. Translation: ACA32478.1 .
    RefSeqi WP_012341620.1. NC_010519.1.
    YP_001784141.1. NC_010519.1.

    3D structure databases

    ProteinModelPortali B0USP2.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 228400.HSM_0805.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA32478 ; ACA32478 ; HSM_0805 .
    GeneIDi 6108625.
    KEGGi hsm:HSM_0805.
    PATRICi 20198731. VBIHaeSom93646_0853.

    Phylogenomic databases

    eggNOGi COG0295.
    HOGENOMi HOG000218617.
    KOi K01489.
    OrthoDBi EOG6XDH25.

    Enzyme and pathway databases

    BioCyci HSOM228400:GHWT-829-MONOMER.

    Family and domain databases

    HAMAPi MF_01558. Cyt_deam.
    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR013171. Cyd/dCyd_deaminase_Zn-bd.
    IPR006263. Cyt_deam_dimer.
    IPR016193. Cytidine_deaminase-like.
    IPR020797. Cytidine_deaminase_bacteria.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    PF08211. dCMP_cyt_deam_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006334. Cdd_plus_pseudo. 1 hit.
    SUPFAMi SSF53927. SSF53927. 2 hits.
    TIGRFAMsi TIGR01355. cyt_deam_dimer. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2336.

    Entry informationi

    Entry nameiCDD_HISS2
    AccessioniPrimary (citable) accession number: B0USP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: September 3, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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