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Protein

Cytidine deaminase

Gene

cdd

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.UniRule annotation

Catalytic activityi

Cytidine + H2O = uridine + NH3.UniRule annotation
2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi111Zinc; catalyticUniRule annotation1
Active sitei113Proton donorUniRule annotation1
Metal bindingi138Zinc; catalyticUniRule annotation1
Metal bindingi141Zinc; catalyticUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciHSOM228400:G1GB8-836-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine deaminaseUniRule annotation (EC:3.5.4.5UniRule annotation)
Alternative name(s):
Cytidine aminohydrolaseUniRule annotation
Short name:
CDAUniRule annotation
Gene namesi
Name:cddUniRule annotation
Ordered Locus Names:HSM_0805
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
Proteomesi
  • UP000008543 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000877941 – 303Cytidine deaminaseAdd BLAST303

Proteomic databases

PRIDEiB0USP2

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0USP2
SMRiB0USP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 172CMP/dCMP-type deaminase 1PROSITE-ProRule annotationAdd BLAST116
Domaini196 – 303CMP/dCMP-type deaminase 2PROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 100Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218617
KOiK01489
OMAiGHIDAQQ
OrthoDBiPOG091H026Y

Family and domain databases

HAMAPiMF_01558 Cyt_deam, 1 hit
InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR013171 Cyd/dCyd_deaminase_Zn-bd
IPR006263 Cyt_deam_dimer
IPR016193 Cytidine_deaminase-like
IPR020797 Cytidine_deaminase_bacteria
PfamiView protein in Pfam
PF00383 dCMP_cyt_deam_1, 1 hit
PF08211 dCMP_cyt_deam_2, 1 hit
SUPFAMiSSF53927 SSF53927, 2 hits
TIGRFAMsiTIGR01355 cyt_deam_dimer, 1 hit
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 2 hits

Sequencei

Sequence statusi: Complete.

B0USP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHHSLKHIS DRIKQALNQI ENRNLAQDLW YILGEQNFQG FLPAFTVNHF
60 70 80 90 100
CEKYHMTDKE LALILLPVSA CYANPTISHF SVGAIAKGES GNFYFGANQE
110 120 130 140 150
FCTTNIQQTV HAEQSAISHA WMRRESKITE ITVNYTPCGH CRQFMNELNS
160 170 180 190 200
AETLRIHLPH SQDNLLHHYL PDAFGPHNLQ IDNRLFDKKA HNLFLITEDP
210 220 230 240 250
LIQAALDAAN QSHAPYSKTY SGIALQLQDQ QIFQGSYAEN AAFNPSLPPL
260 270 280 290 300
QTALNYLLLN GNEVENIARA VLVEQPFRLS YRGMTEELLA YLGDIPLDYI

QVS
Length:303
Mass (Da):34,354
Last modified:April 8, 2008 - v1
Checksum:i80554A8D43223190
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA Translation: ACA32478.1
RefSeqiWP_012341620.1, NC_010519.1

Genome annotation databases

EnsemblBacteriaiACA32478; ACA32478; HSM_0805
GeneIDi31487094
KEGGihsm:HSM_0805

Similar proteinsi

Entry informationi

Entry nameiCDD_HISS2
AccessioniPrimary (citable) accession number: B0USP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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