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B0URN5

- PUR5_HISS2

UniProt

B0URN5 - PUR5_HISS2

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHSOM228400:GHWT-486-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:HSM_0473
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000008543: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000083460Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228400.HSM_0473.

Structurei

3D structure databases

ProteinModelPortaliB0URN5.
SMRiB0URN5. Positions 5-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B0URN5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKQSLSYKD AGVDINAGNT LVERIKSDVK RTTRPEVIGG LGGFGALCAL
60 70 80 90 100
PSKYKDPILV SGTDGVGTKL RLAIDLKKHD TIGVDLVAMC VNDLVVQGAE
110 120 130 140 150
PLFFLDYYAT GKLDVDVAAD VIKGIADGCV QAGCALVGGE TAEMPGMYHT
160 170 180 190 200
GDYDLAGFCV GVVEKSEIID GSNVKAGDAL LALASSGPHS NGYSLIRKVI
210 220 230 240 250
EVSGIDPTTA QLAEHSFAEQ VLAPTKIYVK PVLQLIKHTD VHAICHLTGG
260 270 280 290 300
GFWENIPRVL PSSVKAVINE KSWEWHPIFK WLQEQGNIDR YEMYRTFNCG
310 320 330 340
VGMIIALPQE DVETALALLQ QVGEKAWVIG KIEHANADEE KVVIC
Length:345
Mass (Da):37,079
Last modified:April 8, 2008 - v1
Checksum:i8ED7EE4FFE873775
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA32119.1.
RefSeqiWP_012341311.1. NC_010519.1.
YP_001783819.1. NC_010519.1.

Genome annotation databases

EnsemblBacteriaiACA32119; ACA32119; HSM_0473.
GeneIDi6108261.
KEGGihsm:HSM_0473.
PATRICi20197975. VBIHaeSom93646_0492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA32119.1 .
RefSeqi WP_012341311.1. NC_010519.1.
YP_001783819.1. NC_010519.1.

3D structure databases

ProteinModelPortali B0URN5.
SMRi B0URN5. Positions 5-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228400.HSM_0473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA32119 ; ACA32119 ; HSM_0473 .
GeneIDi 6108261.
KEGGi hsm:HSM_0473.
PATRICi 20197975. VBIHaeSom93646_0492.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci HSOM228400:GHWT-486-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2336.

Entry informationi

Entry nameiPUR5_HISS2
AccessioniPrimary (citable) accession number: B0URN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: November 26, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3