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B0URN5

- PUR5_HISS2

UniProt

B0URN5 - PUR5_HISS2

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Protein
Phosphoribosylformylglycinamidine cyclo-ligase
Gene
purM, HSM_0473
Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHSOM228400:GHWT-486-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:HSM_0473
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000008543: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation
PRO_1000083460Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228400.HSM_0473.

Structurei

3D structure databases

ProteinModelPortaliB0URN5.
SMRiB0URN5. Positions 5-344.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B0URN5-1 [UniParc]FASTAAdd to Basket

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MSKQSLSYKD AGVDINAGNT LVERIKSDVK RTTRPEVIGG LGGFGALCAL    50
PSKYKDPILV SGTDGVGTKL RLAIDLKKHD TIGVDLVAMC VNDLVVQGAE 100
PLFFLDYYAT GKLDVDVAAD VIKGIADGCV QAGCALVGGE TAEMPGMYHT 150
GDYDLAGFCV GVVEKSEIID GSNVKAGDAL LALASSGPHS NGYSLIRKVI 200
EVSGIDPTTA QLAEHSFAEQ VLAPTKIYVK PVLQLIKHTD VHAICHLTGG 250
GFWENIPRVL PSSVKAVINE KSWEWHPIFK WLQEQGNIDR YEMYRTFNCG 300
VGMIIALPQE DVETALALLQ QVGEKAWVIG KIEHANADEE KVVIC 345
Length:345
Mass (Da):37,079
Last modified:April 8, 2008 - v1
Checksum:i8ED7EE4FFE873775
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000947 Genomic DNA. Translation: ACA32119.1.
RefSeqiYP_001783819.1. NC_010519.1.

Genome annotation databases

EnsemblBacteriaiACA32119; ACA32119; HSM_0473.
GeneIDi6108261.
KEGGihsm:HSM_0473.
PATRICi20197975. VBIHaeSom93646_0492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000947 Genomic DNA. Translation: ACA32119.1 .
RefSeqi YP_001783819.1. NC_010519.1.

3D structure databases

ProteinModelPortali B0URN5.
SMRi B0URN5. Positions 5-344.
ModBasei Search...

Protein-protein interaction databases

STRINGi 228400.HSM_0473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA32119 ; ACA32119 ; HSM_0473 .
GeneIDi 6108261.
KEGGi hsm:HSM_0473.
PATRICi 20197975. VBIHaeSom93646_0492.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci HSOM228400:GHWT-486-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2336.

Entry informationi

Entry nameiPUR5_HISS2
AccessioniPrimary (citable) accession number: B0URN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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