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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHSOM228400:G1GB8-490-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:HSM_0473
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
Proteomesi
  • UP000008543 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000834601 – 345Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST345

Structurei

3D structure databases

ProteinModelPortaliB0URN5.
SMRiB0URN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229090.
KOiK01933.
OMAiNHCVNDI.
OrthoDBiPOG091H0128.

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiView protein in InterPro
IPR010918. PurM-like_C_dom.
IPR036676. PurM-like_C_sf.
IPR016188. PurM-like_N.
IPR036921. PurM-like_N_sf.
IPR004733. PurM_cligase.
PANTHERiPTHR10520. PTHR10520. 1 hit.
PfamiView protein in Pfam
PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B0URN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKQSLSYKD AGVDINAGNT LVERIKSDVK RTTRPEVIGG LGGFGALCAL
60 70 80 90 100
PSKYKDPILV SGTDGVGTKL RLAIDLKKHD TIGVDLVAMC VNDLVVQGAE
110 120 130 140 150
PLFFLDYYAT GKLDVDVAAD VIKGIADGCV QAGCALVGGE TAEMPGMYHT
160 170 180 190 200
GDYDLAGFCV GVVEKSEIID GSNVKAGDAL LALASSGPHS NGYSLIRKVI
210 220 230 240 250
EVSGIDPTTA QLAEHSFAEQ VLAPTKIYVK PVLQLIKHTD VHAICHLTGG
260 270 280 290 300
GFWENIPRVL PSSVKAVINE KSWEWHPIFK WLQEQGNIDR YEMYRTFNCG
310 320 330 340
VGMIIALPQE DVETALALLQ QVGEKAWVIG KIEHANADEE KVVIC
Length:345
Mass (Da):37,079
Last modified:April 8, 2008 - v1
Checksum:i8ED7EE4FFE873775
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA32119.1.
RefSeqiWP_012341311.1. NC_010519.1.

Genome annotation databases

EnsemblBacteriaiACA32119; ACA32119; HSM_0473.
GeneIDi31486756.
KEGGihsm:HSM_0473.

Similar proteinsi

Entry informationi

Entry nameiPUR5_HISS2
AccessioniPrimary (citable) accession number: B0URN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: February 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome