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B0URM9

- SYL_HISS2

UniProt

B0URM9 - SYL_HISS2

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Histophilus somni (strain 2336) (Haemophilus somnus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHSOM228400:GHWT-480-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:HSM_0467
OrganismiHistophilus somni (strain 2336) (Haemophilus somnus)
Taxonomic identifieri228400 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHistophilus
ProteomesiUP000008543: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Leucine--tRNA ligasePRO_1000074836Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228400.HSM_0467.

Structurei

3D structure databases

ProteinModelPortaliB0URM9.
SMRiB0URM9. Positions 228-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi619 – 6235"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0URM9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEQYRPDLI EADVQKYWAE KKTFKAVKDP FKEKYYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRMNG KNVLQPMGWD AFGLPAEGAA IKNKTAPAKW
110 120 130 140 150
TYENIEYMKN QLKVLGFGFD WDREITTCKP EYYKWEQWFF TELYKKGLVY
160 170 180 190 200
KKTSTVNWCP NDETVLANEQ VHEGGCWRCD TPVEQKEIPQ WFIKITDYAE
210 220 230 240 250
QLLSDLDQLP EWPDMVKTMQ RNWIGRSEGV EITFNVAHSD QTLTVYTTRP
260 270 280 290 300
DTFYGVSYLA VAAAHPLAEN AAKNNPELAA FIHEAKNTKV AEAELATMEK
310 320 330 340 350
KGMATGLYAV HPMTGKQLPI WVANFVLMHY GTGAVMAVPA HDQRDYEFAQ
360 370 380 390 400
KYQLPLFPVI KPADNSAWDF SKQAYTEHGI TINSAEFDGL DFEATFNGIA
410 420 430 440 450
DKLEKIGVGK RQVNYRLRDW GVSRQRYWGA PIPMLTLENG DVVVAPLQDL
460 470 480 490 500
PIVLPEDVVM DGVKSPIKAD PEWAKTTYNG QVALKETDTF DTFMESSWYY
510 520 530 540 550
ARYTSPQYQQ AMLDADETNY WLPVDQYIGG IEHATMHLLY FRFFHKLLRD
560 570 580 590 600
AGFVTSDEPS KKLLCQGMVL ADAFYYTSPT NERIWVSPTK VTLERDEKGR
610 620 630 640 650
IIKAVDDEGH ELVHSGMTKM SKSKNNGIDP QEMVEKYGAD TVRLFMMFAS
660 670 680 690 700
PAEMTLEWQE SGVEGANRFL RRLWNLVFEY NQNPAQTALD PTALSVEQKA
710 720 730 740 750
LRREVHKTIA KVSDDIGRRQ TFNTAIAAIM ELMNKLTKAS LSNEQDRAVM
760 770 780 790 800
AEALNAVVRM LYPITPHICF QLWQDLGNES AIDFAPWVIA DAEAMVEDEK
810 820 830 840 850
LVVIQVNGKV RAKVTVPADM SEDEIKQVAL AEENVQKFLN GLTVVKTIYV
860
PGKLFSFVAK
Length:860
Mass (Da):98,163
Last modified:April 8, 2008 - v1
Checksum:i2CE05913359BC5AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA32112.1.
RefSeqiYP_001783813.1. NC_010519.1.

Genome annotation databases

EnsemblBacteriaiACA32112; ACA32112; HSM_0467.
GeneIDi6108254.
KEGGihsm:HSM_0467.
PATRICi20197963. VBIHaeSom93646_0486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000947 Genomic DNA. Translation: ACA32112.1 .
RefSeqi YP_001783813.1. NC_010519.1.

3D structure databases

ProteinModelPortali B0URM9.
SMRi B0URM9. Positions 228-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228400.HSM_0467.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA32112 ; ACA32112 ; HSM_0467 .
GeneIDi 6108254.
KEGGi hsm:HSM_0467.
PATRICi 20197963. VBIHaeSom93646_0486.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HSOM228400:GHWT-480-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2336.

Entry informationi

Entry nameiSYL_HISS2
AccessioniPrimary (citable) accession number: B0URM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3