ID   APAH_HAES2              Reviewed;         273 AA.
AC   B0URM8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   16-JUN-2009, entry version 7.
DE   RecName: Full=Bis(5'-nucleosyl)-tetraphosphatase, symmetrical;
DE            EC=3.6.1.41;
DE   AltName: Full=Diadenosine tetraphosphatase;
DE   AltName: Full=Ap4A hydrolase;
DE   AltName: Full=Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase;
GN   Name=apaH; OrderedLocusNames=HSM_0466;
OS   Haemophilus somnus (strain 2336) (Histophilus somni (strain 2336)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Histophilus.
OX   NCBI_TaxID=228400;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Siddaramappa S., Duncan A.J., Challacombe J.F., Rainey D.,
RA   Gillaspy A.F., Carson M., Gipson J., Gipson M., Bruce D., Detter J.C.,
RA   Han C.S., Land M., Tapia R., Thompson L.S., Orvis J., Zaitshik J.,
RA   Barnes G., Brettin T.S., Dyer D.W., Inzana T.J.;
RT   "Complete sequence of Haemophilus somnus 2336.";
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to
CC       yield ADP (By similarity).
CC   -!- CATALYTIC ACTIVITY: P(1),P(4)-bis(5'-adenosyl) tetraphosphate +
CC       H(2)O = 2 ADP.
CC   -!- SIMILARITY: Belongs to the Ap4A hydrolase family.
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DR   EMBL; CP000947; ACA32111.1; -; Genomic_DNA.
DR   RefSeq; YP_001783812.1; -.
DR   GeneID; 6108253; -.
DR   GenomeReviews; CP000947_GR; HSM_0466.
DR   KEGG; hsm:HSM_0466; -.
DR   OMA; B0URM8; LVFGHWA.
DR   GO; GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetr...; IEA:HAMAP.
DR   HAMAP; MF_00199; -; 1.
DR   InterPro; IPR004617; ApaH.
DR   InterPro; IPR004843; M-pesterase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF000903; B5n-ttraPtase_sm; 1.
DR   TIGRFAMs; TIGR00668; apaH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase.
FT   CHAIN         1    273       Bis(5'-nucleosyl)-tetraphosphatase,
FT                                symmetrical.
FT                                /FTId=PRO_1000077715.
SQ   SEQUENCE   273 AA;  31465 MW;  2C25191E68CC14FF CRC64;
     MATYLVGDLQ GCYDELQLLL ETVQFNPVQD KLYLVGDLVA RGDKSLECLR FVKSLGAAAQ
     MVLGNHDLHL ISTALGIKKV SLQDHVEAIF TAPDFVELID WLRHQPLLVH DEKCDFVMSH
     AGISPDWDLD TAKSCAREVE NELQHGDYHY LISNMYDNQP DRWSADLQGL QRLRYSINVF
     TRMRFCYRDH RLDFACKASV EKAPQELIPW FNLDNPLFKV QNLVFGHWAS LVDTPTPANI
     YALDTGCVWG NRMTMLRWED KQYFVQGALK DYF
//