Reviewed, UniProtKB/Swiss-Prot B0URM8 (APAH_HAES2)

Names and origin

Protein names

Recommended name:
    Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
    EC=3.6.1.41
Alternative name(s):
    Diadenosine tetraphosphatase
    Ap4A hydrolase
    Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase

Gene names

Name:	apaH
Ordered Locus Names:	HSM_0466

Organism

Haemophilus somnus (strain 2336) (Histophilus somni (strain 2336)) [Complete proteome] [HAMAP]

Taxonomic identifier

228400 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Histophilus

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP By similarity.
Catalytic activity	P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP. HAMAP MF_00199
Sequence similarities	Belongs to the Ap4A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Bis(5'-nucleosyl)-tetraphosphatase, symmetrical HAMAP MF_00199		PRO_1000077715

Sequences

	Sequence		Length	Mass (Da)
	B0URM8-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 2C25191E68CC14FF	FASTA	273	31,465
	10 20 30 40 50 60 MATYLVGDLQ GCYDELQLLL ETVQFNPVQD KLYLVGDLVA RGDKSLECLR FVKSLGAAAQ 70 80 90 100 110 120 MVLGNHDLHL ISTALGIKKV SLQDHVEAIF TAPDFVELID WLRHQPLLVH DEKCDFVMSH 130 140 150 160 170 180 AGISPDWDLD TAKSCAREVE NELQHGDYHY LISNMYDNQP DRWSADLQGL QRLRYSINVF 190 200 210 220 230 240 TRMRFCYRDH RLDFACKASV EKAPQELIPW FNLDNPLFKV QNLVFGHWAS LVDTPTPANI 250 260 270 YALDTGCVWG NRMTMLRWED KQYFVQGALK DYF

References

[1]

"Complete sequence of Haemophilus somnus 2336." Siddaramappa S., Duncan A.J., Challacombe J.F., Rainey D., Gillaspy A.F., Carson M., Gipson J., Gipson M., Bruce D., Detter J.C., Han C.S., Land M., Tapia R., Thompson L.S., Orvis J., Zaitshik J., Barnes G., Brettin T.S., Dyer D.W., Inzana T.J. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000947 Genomic DNA. Translation: ACA32111.1.
RefSeq	YP_001783812.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6108253.
GenomeReviews	Gene locus HSM_0466 in contig CP000947_GR.
KEGG	hsm:HSM_0466.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	B0URM8. LVFGHWA.
Family and domain databases
HAMAP	MF_00199. [Tree]
InterPro	IPR004617. ApaH. IPR004843. M-pesterase. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
PIRSF	PIRSF000903. B5n-ttraPtase_sm. 1 hit.
TIGRFAMs	TIGR00668. apaH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APAH_HAES2

Accession

Primary (citable) accession number: B0URM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	June 16, 2009
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)