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Protein

Glutaminase

Gene

glsA

Organism
Methylobacterium sp. (strain 4-46)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64SubstrateUniRule annotation1
Binding sitei114SubstrateUniRule annotation1
Binding sitei160SubstrateUniRule annotation1
Binding sitei167SubstrateUniRule annotation1
Binding sitei191SubstrateUniRule annotation1
Binding sitei243SubstrateUniRule annotation1
Binding sitei261Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:M446_4570
OrganismiMethylobacterium sp. (strain 4-46)
Taxonomic identifieri426117 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000001185 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001195341 – 309GlutaminaseAdd BLAST309

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi426117.M446_4570.

Structurei

3D structure databases

ProteinModelPortaliB0UQS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSV. Bacteria.
COG2066. LUCA.
HOGENOMiHOG000216890.
KOiK01425.
OMAiANYMKSF.
OrthoDBiPOG091H02PU.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

B0UQS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLTRVVTE IAEEMRARPD RGEVATYIPE LARMDPRAFG MVVIDADGEV
60 70 80 90 100
AAAGDCDVPF SIQSISKVFT LTLALGMVGD RLWRRVGREP SGSPFNSIVQ
110 120 130 140 150
LEYERGIPRN PFINAGAIAV TDVILSRHQP REALGEILRF LQFLAGDAAI
160 170 180 190 200
AIDESVAASE QRTGYRNMAL ANFMKAHGVL DNPVPYLLGV YFHHCAIAMT
210 220 230 240 250
CRQLAEAGRF LAHSGRHPAT GHLVVQPERA RRINAVMLTC GHYDGSGEFA
260 270 280 290 300
YRVGLPGKSG VGGGILAIAP GRASIAVWSP GLDAAGNSHL GRIALEMLTK

RLGWSIFGQ
Length:309
Mass (Da):33,331
Last modified:April 8, 2008 - v1
Checksum:i6D75F9B0517EFFAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000943 Genomic DNA. Translation: ACA18911.1.
RefSeqiWP_012334300.1. NC_010511.1.

Genome annotation databases

EnsemblBacteriaiACA18911; ACA18911; M446_4570.
KEGGimet:M446_4570.
PATRICi22590314. VBIMetSp32184_4487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000943 Genomic DNA. Translation: ACA18911.1.
RefSeqiWP_012334300.1. NC_010511.1.

3D structure databases

ProteinModelPortaliB0UQS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi426117.M446_4570.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA18911; ACA18911; M446_4570.
KEGGimet:M446_4570.
PATRICi22590314. VBIMetSp32184_4487.

Phylogenomic databases

eggNOGiENOG4105CSV. Bacteria.
COG2066. LUCA.
HOGENOMiHOG000216890.
KOiK01425.
OMAiANYMKSF.
OrthoDBiPOG091H02PU.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLSA_METS4
AccessioniPrimary (citable) accession number: B0UQS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.