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B0UQF5 (FTHS_METS4) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:M446_3236
OrganismMethylobacterium sp. (strain 4-46) [Complete proteome] [HAMAP]
Taxonomic identifier426117 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000196817

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B0UQF5 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 809172289340E0AE

FASTA55858,766
        10         20         30         40         50         60 
MPTDIEIARA ATLQPISAIA ETLGIPDEAL HPYGRHIAKI DHAHIASLEA KPEGKLVLVT 

        70         80         90        100        110        120 
AISPTPAGEG KTTTTVGLGD ALNRIGKRTV ICLREPSLGP CFGMKGGAAG GGRSQVVPME 

       130        140        150        160        170        180 
AINLHFTGDF HAITSAHSLA AALIDNHIYW GNALGIDPRR VAWRRVVDMN DRSLRSIVQS 

       190        200        210        220        230        240 
LGGVANGYPR EDGFDITVAS EVMAVFCLAR DLADLEARLG RIVVAESRER KPVTLADLKA 

       250        260        270        280        290        300 
TGAMTVLLKD ALQPNLVQTL EGSPALIHGG PFANIAHGCN SVIATRSGLR LGEYAVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF IDIKCRQTGL SPSAVVIVAT VRALKMHGGV EKKALGGENV AALEKGFANL 

       370        380        390        400        410        420 
QRHVENVRRF GLPVVVAVNH FHADTEAEHA ALKALCRDRL DVQAITCRHW AEGGAGAEDL 

       430        440        450        460        470        480 
ARAVVSLAEG GAPATPNFVY PEEAKLTDKI RTIAQTLYGA ADIQVESKAA AKLAQFEKDG 

       490        500        510        520        530        540 
YGRLPVCMAK TQYSFSTDPG LIGAPSGHVV AVRDVRLSAG AGFVVVICGE IMTMPGLPKV 

       550 
PASEGIYLDA NGQIEGLF 

« Hide

References

[1]"Complete sequence of chromosome of Methylobacterium sp. 4-46."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Ivanova N., Marx C.J., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 4-46.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000943 Genomic DNA. Translation: ACA17641.1.
RefSeqYP_001770075.1. NC_010511.1.

3D structure databases

ProteinModelPortalB0UQF5.
SMRB0UQF5. Positions 4-556.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING426117.M446_3236.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA17641; ACA17641; M446_3236.
GeneID6134958.
KEGGmet:M446_3236.
PATRIC22587725. VBIMetSp32184_3210.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAIANSVSM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycMSP426117:GI2I-3264-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_METS4
AccessionPrimary (citable) accession number: B0UQF5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways