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B0UQF5

- FTHS_METS4

UniProt

B0UQF5 - FTHS_METS4

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, M446_3236
Organism
Methylobacterium sp. (strain 4-46)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP426117:GI2I-3264-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:M446_3236
OrganismiMethylobacterium sp. (strain 4-46)
Taxonomic identifieri426117 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000001185: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000196817Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi426117.M446_3236.

Structurei

3D structure databases

ProteinModelPortaliB0UQF5.
SMRiB0UQF5. Positions 4-556.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0UQF5-1 [UniParc]FASTAAdd to Basket

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MPTDIEIARA ATLQPISAIA ETLGIPDEAL HPYGRHIAKI DHAHIASLEA    50
KPEGKLVLVT AISPTPAGEG KTTTTVGLGD ALNRIGKRTV ICLREPSLGP 100
CFGMKGGAAG GGRSQVVPME AINLHFTGDF HAITSAHSLA AALIDNHIYW 150
GNALGIDPRR VAWRRVVDMN DRSLRSIVQS LGGVANGYPR EDGFDITVAS 200
EVMAVFCLAR DLADLEARLG RIVVAESRER KPVTLADLKA TGAMTVLLKD 250
ALQPNLVQTL EGSPALIHGG PFANIAHGCN SVIATRSGLR LGEYAVTEAG 300
FGADLGAEKF IDIKCRQTGL SPSAVVIVAT VRALKMHGGV EKKALGGENV 350
AALEKGFANL QRHVENVRRF GLPVVVAVNH FHADTEAEHA ALKALCRDRL 400
DVQAITCRHW AEGGAGAEDL ARAVVSLAEG GAPATPNFVY PEEAKLTDKI 450
RTIAQTLYGA ADIQVESKAA AKLAQFEKDG YGRLPVCMAK TQYSFSTDPG 500
LIGAPSGHVV AVRDVRLSAG AGFVVVICGE IMTMPGLPKV PASEGIYLDA 550
NGQIEGLF 558
Length:558
Mass (Da):58,766
Last modified:April 8, 2008 - v1
Checksum:i809172289340E0AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000943 Genomic DNA. Translation: ACA17641.1.
RefSeqiYP_001770075.1. NC_010511.1.

Genome annotation databases

EnsemblBacteriaiACA17641; ACA17641; M446_3236.
GeneIDi6134958.
KEGGimet:M446_3236.
PATRICi22587725. VBIMetSp32184_3210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000943 Genomic DNA. Translation: ACA17641.1 .
RefSeqi YP_001770075.1. NC_010511.1.

3D structure databases

ProteinModelPortali B0UQF5.
SMRi B0UQF5. Positions 4-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 426117.M446_3236.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA17641 ; ACA17641 ; M446_3236 .
GeneIDi 6134958.
KEGGi met:M446_3236.
PATRICi 22587725. VBIMetSp32184_3210.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MSP426117:GI2I-3264-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 4-46.

Entry informationi

Entry nameiFTHS_METS4
AccessioniPrimary (citable) accession number: B0UQF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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