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B0UQF5

- FTHS_METS4

UniProt

B0UQF5 - FTHS_METS4

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Methylobacterium sp. (strain 4-46)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP426117:GI2I-3264-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:M446_3236
OrganismiMethylobacterium sp. (strain 4-46)
Taxonomic identifieri426117 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000001185: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Formate--tetrahydrofolate ligasePRO_1000196817Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi426117.M446_3236.

Structurei

3D structure databases

ProteinModelPortaliB0UQF5.
SMRiB0UQF5. Positions 4-556.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0UQF5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTDIEIARA ATLQPISAIA ETLGIPDEAL HPYGRHIAKI DHAHIASLEA
60 70 80 90 100
KPEGKLVLVT AISPTPAGEG KTTTTVGLGD ALNRIGKRTV ICLREPSLGP
110 120 130 140 150
CFGMKGGAAG GGRSQVVPME AINLHFTGDF HAITSAHSLA AALIDNHIYW
160 170 180 190 200
GNALGIDPRR VAWRRVVDMN DRSLRSIVQS LGGVANGYPR EDGFDITVAS
210 220 230 240 250
EVMAVFCLAR DLADLEARLG RIVVAESRER KPVTLADLKA TGAMTVLLKD
260 270 280 290 300
ALQPNLVQTL EGSPALIHGG PFANIAHGCN SVIATRSGLR LGEYAVTEAG
310 320 330 340 350
FGADLGAEKF IDIKCRQTGL SPSAVVIVAT VRALKMHGGV EKKALGGENV
360 370 380 390 400
AALEKGFANL QRHVENVRRF GLPVVVAVNH FHADTEAEHA ALKALCRDRL
410 420 430 440 450
DVQAITCRHW AEGGAGAEDL ARAVVSLAEG GAPATPNFVY PEEAKLTDKI
460 470 480 490 500
RTIAQTLYGA ADIQVESKAA AKLAQFEKDG YGRLPVCMAK TQYSFSTDPG
510 520 530 540 550
LIGAPSGHVV AVRDVRLSAG AGFVVVICGE IMTMPGLPKV PASEGIYLDA

NGQIEGLF
Length:558
Mass (Da):58,766
Last modified:April 8, 2008 - v1
Checksum:i809172289340E0AE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000943 Genomic DNA. Translation: ACA17641.1.
RefSeqiYP_001770075.1. NC_010511.1.

Genome annotation databases

EnsemblBacteriaiACA17641; ACA17641; M446_3236.
GeneIDi6134958.
KEGGimet:M446_3236.
PATRICi22587725. VBIMetSp32184_3210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000943 Genomic DNA. Translation: ACA17641.1 .
RefSeqi YP_001770075.1. NC_010511.1.

3D structure databases

ProteinModelPortali B0UQF5.
SMRi B0UQF5. Positions 4-556.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 426117.M446_3236.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA17641 ; ACA17641 ; M446_3236 .
GeneIDi 6134958.
KEGGi met:M446_3236.
PATRICi 22587725. VBIMetSp32184_3210.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci MSP426117:GI2I-3264-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 4-46.

Entry informationi

Entry nameiFTHS_METS4
AccessioniPrimary (citable) accession number: B0UQF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3