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Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Methylobacterium sp. (strain 4-46)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
Short name:
(3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
Gene namesi
Name:fabZUniRule annotation
Ordered Locus Names:M446_0642
OrganismiMethylobacterium sp. (strain 4-46)
Taxonomic identifieri426117 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000001185 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003407881 – 1653-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZAdd BLAST165

Interactioni

Protein-protein interaction databases

STRINGi426117.M446_0642

Structurei

3D structure databases

ProteinModelPortaliB0UQ04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108YXN Bacteria
COG0764 LUCA
HOGENOMiHOG000277829
KOiK02372
OMAiGIDECRF
OrthoDBiPOG091H005Q

Family and domain databases

HAMAPiMF_00406 FabZ, 1 hit
InterProiView protein in InterPro
IPR013114 FabA_FabZ
IPR010084 FabZ
IPR029069 HotDog_dom_sf
PfamiView protein in Pfam
PF07977 FabA, 1 hit
SUPFAMiSSF54637 SSF54637, 1 hit
TIGRFAMsiTIGR01750 fabZ, 1 hit

Sequencei

Sequence statusi: Complete.

B0UQ04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPDAKSPTP GTTETPRELA TADILRVMEL LPHRYPFLLV DRIVEIDGDS
60 70 80 90 100
SCIGIKNVTI NEPQFTGHFP KVPVFPGVLL VEGMAQTAGA ICCAHTLTRD
110 120 130 140 150
TRPSRVYLMT IDKVKFRKPV VPGDTVEYHM RKLTNRRTMW WFRGEAKVAG
160
TLVAEAEIGA MLVTE
Length:165
Mass (Da):18,393
Last modified:April 8, 2008 - v1
Checksum:i2C9A79DF2F440F04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000943 Genomic DNA Translation: ACA15203.1
RefSeqiWP_012330620.1, NC_010511.1

Genome annotation databases

EnsemblBacteriaiACA15203; ACA15203; M446_0642
KEGGimet:M446_0642

Similar proteinsi

Entry informationi

Entry nameiFABZ_METS4
AccessioniPrimary (citable) accession number: B0UQ04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 8, 2008
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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