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B0UP40

- TRUA_METS4

UniProt

B0UP40 - TRUA_METS4

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Protein
tRNA pseudouridine synthase A
Gene
truA, M446_4238
Organism
Methylobacterium sp. (strain 4-46)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs By similarity.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521Nucleophile By similarity
Binding sitei111 – 1111Substrate By similarity

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. pseudouridine synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciMSP426117:GI2I-4279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase A (EC:5.4.99.12)
Alternative name(s):
tRNA pseudouridine(38-40) synthase
tRNA pseudouridylate synthase I
tRNA-uridine isomerase I
Gene namesi
Name:truA
Ordered Locus Names:M446_4238
OrganismiMethylobacterium sp. (strain 4-46)
Taxonomic identifieri426117 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000001185: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250tRNA pseudouridine synthase AUniRule annotation
PRO_1000097763Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi426117.M446_4238.

Structurei

3D structure databases

ProteinModelPortaliB0UP40.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0101.
HOGENOMiHOG000248674.
KOiK06173.
OMAiWDPFRLS.
OrthoDBiEOG6Z9B4R.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

Sequencei

Sequence statusi: Complete.

B0UP40-1 [UniParc]FASTAAdd to Basket

« Hide

MPRYKLVVEY DGSGFAGWQR QAADRTVQQA LEEAIARFAG APVRVHCAGR    50
TDAGVHATHQ VVHLDLDRDW RTDTVRDASN AHLRPEPVAV VSAERVRPDF 100
DARHSALRRH YRYRILNRRS PPALGRAYLW HVPWSLDAHA MHAAAQTLLG 150
RHDFSAFRAA ECQANSPVRT LDQLDVARIG DEILVATSAR SFLHHQVRGM 200
VGTLMLAGCG RLDAAGVRAV LDSRDRTRCG PLAPAAGLTL TGVDYPEPGP 250
Length:250
Mass (Da):27,525
Last modified:April 8, 2008 - v1
Checksum:i626195D8767B5600
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000943 Genomic DNA. Translation: ACA18587.1.
RefSeqiWP_012333978.1. NC_010511.1.
YP_001771021.1. NC_010511.1.

Genome annotation databases

EnsemblBacteriaiACA18587; ACA18587; M446_4238.
GeneIDi6129982.
KEGGimet:M446_4238.
PATRICi22589646. VBIMetSp32184_4157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000943 Genomic DNA. Translation: ACA18587.1 .
RefSeqi WP_012333978.1. NC_010511.1.
YP_001771021.1. NC_010511.1.

3D structure databases

ProteinModelPortali B0UP40.
ModBasei Search...

Protein-protein interaction databases

STRINGi 426117.M446_4238.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA18587 ; ACA18587 ; M446_4238 .
GeneIDi 6129982.
KEGGi met:M446_4238.
PATRICi 22589646. VBIMetSp32184_4157.

Phylogenomic databases

eggNOGi COG0101.
HOGENOMi HOG000248674.
KOi K06173.
OMAi WDPFRLS.
OrthoDBi EOG6Z9B4R.

Enzyme and pathway databases

BioCyci MSP426117:GI2I-4279-MONOMER.

Family and domain databases

Gene3Di 3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPi MF_00171. TruA.
InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view ]
PANTHERi PTHR11142. PTHR11142. 1 hit.
Pfami PF01416. PseudoU_synth_1. 2 hits.
[Graphical view ]
PIRSFi PIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMi SSF55120. SSF55120. 1 hit.
TIGRFAMsi TIGR00071. hisT_truA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 4-46.

Entry informationi

Entry nameiTRUA_METS4
AccessioniPrimary (citable) accession number: B0UP40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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