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B0UP40

- TRUA_METS4

UniProt

B0UP40 - TRUA_METS4

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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Methylobacterium sp. (strain 4-46)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521NucleophileUniRule annotation
Binding sitei111 – 1111SubstrateUniRule annotation

GO - Molecular functioni

  1. pseudouridine synthase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: InterPro

GO - Biological processi

  1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

tRNA processing

Enzyme and pathway databases

BioCyciMSP426117:GI2I-4279-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:M446_4238
OrganismiMethylobacterium sp. (strain 4-46)
Taxonomic identifieri426117 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000001185: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250tRNA pseudouridine synthase APRO_1000097763Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi426117.M446_4238.

Structurei

3D structure databases

ProteinModelPortaliB0UP40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0101.
HOGENOMiHOG000248674.
KOiK06173.
OMAiWDPFRLS.
OrthoDBiEOG6Z9B4R.

Family and domain databases

Gene3Di3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPiMF_00171. TruA.
InterProiIPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view]
PANTHERiPTHR11142. PTHR11142. 1 hit.
PfamiPF01416. PseudoU_synth_1. 2 hits.
[Graphical view]
PIRSFiPIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMiSSF55120. SSF55120. 1 hit.
TIGRFAMsiTIGR00071. hisT_truA. 1 hit.

Sequencei

Sequence statusi: Complete.

B0UP40-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRYKLVVEY DGSGFAGWQR QAADRTVQQA LEEAIARFAG APVRVHCAGR
60 70 80 90 100
TDAGVHATHQ VVHLDLDRDW RTDTVRDASN AHLRPEPVAV VSAERVRPDF
110 120 130 140 150
DARHSALRRH YRYRILNRRS PPALGRAYLW HVPWSLDAHA MHAAAQTLLG
160 170 180 190 200
RHDFSAFRAA ECQANSPVRT LDQLDVARIG DEILVATSAR SFLHHQVRGM
210 220 230 240 250
VGTLMLAGCG RLDAAGVRAV LDSRDRTRCG PLAPAAGLTL TGVDYPEPGP
Length:250
Mass (Da):27,525
Last modified:April 8, 2008 - v1
Checksum:i626195D8767B5600
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000943 Genomic DNA. Translation: ACA18587.1.
RefSeqiWP_012333978.1. NC_010511.1.
YP_001771021.1. NC_010511.1.

Genome annotation databases

EnsemblBacteriaiACA18587; ACA18587; M446_4238.
GeneIDi6129982.
KEGGimet:M446_4238.
PATRICi22589646. VBIMetSp32184_4157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000943 Genomic DNA. Translation: ACA18587.1 .
RefSeqi WP_012333978.1. NC_010511.1.
YP_001771021.1. NC_010511.1.

3D structure databases

ProteinModelPortali B0UP40.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 426117.M446_4238.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA18587 ; ACA18587 ; M446_4238 .
GeneIDi 6129982.
KEGGi met:M446_4238.
PATRICi 22589646. VBIMetSp32184_4157.

Phylogenomic databases

eggNOGi COG0101.
HOGENOMi HOG000248674.
KOi K06173.
OMAi WDPFRLS.
OrthoDBi EOG6Z9B4R.

Enzyme and pathway databases

BioCyci MSP426117:GI2I-4279-MONOMER.

Family and domain databases

Gene3Di 3.30.70.580. 1 hit.
3.30.70.660. 1 hit.
HAMAPi MF_00171. TruA.
InterProi IPR020103. PsdUridine_synth_cat_dom.
IPR001406. PsdUridine_synth_TruA.
IPR020097. PsdUridine_synth_TruA_a/b_dom.
IPR020095. PsdUridine_synth_TruA_C.
IPR020094. PsdUridine_synth_TruA_N.
[Graphical view ]
PANTHERi PTHR11142. PTHR11142. 1 hit.
Pfami PF01416. PseudoU_synth_1. 2 hits.
[Graphical view ]
PIRSFi PIRSF001430. tRNA_psdUrid_synth. 1 hit.
SUPFAMi SSF55120. SSF55120. 1 hit.
TIGRFAMsi TIGR00071. hisT_truA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 4-46.

Entry informationi

Entry nameiTRUA_METS4
AccessioniPrimary (citable) accession number: B0UP40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3