Skip Header

Contribute Send feedback
Read comments (?) or add your own

B0ULS5 (B0ULS5_METS4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
Short name=Coprogen oxidase HAMAP MF_00333
Short name=Coproporphyrinogenase HAMAP MF_00333
EC=1.3.3.3 HAMAP MF_00333
Gene names
Name:hemF HAMAP MF_00333
Ordered Locus Names:M446_6063
OrganismMethylobacterium sp. (strain 4-46) [Complete proteome] [HAMAP]
Taxonomic identifier426117 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 SAAS SAAS001260

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 SAAS SAAS001260

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 SAAS SAAS001260

Subunit structure

Homodimer By similarity. HAMAP MF_00333 SAAS SAAS001260

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family. HAMAP MF_00333

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region73 – 8210Important for dimerization By similarity HAMAP MF_00333
Region133 – 1353Substrate binding By similarity HAMAP MF_00333
Region264 – 29936Important for dimerization By similarity HAMAP MF_00333
Region282 – 2876Substrate binding By similarity HAMAP MF_00333

Sites

Active site1311Proton donor By similarity HAMAP MF_00333
Binding site1171Substrate By similarity HAMAP MF_00333
Site1991Important for dimerization By similarity HAMAP MF_00333

Sequences

Sequence LengthMass (Da)Tools
B0ULS5 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 1E135E1A64E45FA5

FASTA29933,571
        10         20         30         40         50         60 
MSIDASLDLD ALRARATDWF ATLRDRICAA FEALESEAAG PFHPEAEAPG RFVRTPWERT 

        70         80         90        100        110        120 
DHSGAPGGGG VMAMLRGRVF EKAGVHVSAV HGEFAPEFRI QIPGAAEDPR FFATGISLIA 

       130        140        150        160        170        180 
HPWNPNVPTV HMNTRLVVTT KAWFGGGADL TPVLDRRRTQ EDPDSVAFHE ALRRACARHP 

       190        200        210        220        230        240 
GADYARYRTW CDEYFHLKHR NEPRGIGGIF YDYHWSGDPE ADLALTRDVG EAFLEVYPAI 

       250        260        270        280        290 
VRRNLSQPWT EADRREQQVR RGRYVEFNLL YDRGTIFGLK TGGNVDSILS SMPPTVRWP

« Hide

References

[1]"Complete sequence of chromosome of Methylobacterium sp. 4-46."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Ivanova N., Marx C.J., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 4-46.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000943 Genomic DNA. Translation: ACA20340.1.
RefSeqYP_001772774.1. NC_010511.1.

3D structure databases

ProteinModelPortalB0ULS5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0ULS5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6133155.
GenomeReviewsGene locus M446_6063 in contig CP000943_GR.
KEGGmet:M446_6063.
PATRIC22593394. VBIMetSp32184_6005.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG631180.
OMAVKAYLLD.
ProtClustDBPRK05330.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 1 hit.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB0ULS5_METS4
AccessionPrimary (citable) accession number: B0ULS5
Entry history
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info