B0UKH0 (KHSE_METS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	M446_6026

Organism

Methylobacterium sp. (strain 4-46) [Complete proteome] [HAMAP]

Taxonomic identifier

426117 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 321	321	Homoserine kinase HAMAP MF_00301		PRO_1000115435

Sequences

	Sequence		Length	Mass (Da)
	B0UKH0 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 46AC95D7C8BCCE56	FASTA	321	35,224
	10 20 30 40 50 60 MAVYTEVPDE ALAAFLADYD IGGLLSYKGI AEGVENTNFY LHTTVGSYIL TLYEKRVAEG 70 80 90 100 110 120 DLPFFLGLME HLAARGLACP QPIRNRAGTA LGRLCGRPAV IVSFLDGVSV RRPGVRHCRA 130 140 150 160 170 180 LGRALAGLHA AGVDFPMRRP NALSVAAWRP LFAQAEAQAD RVAPNLAART RDDLARLEEA 190 200 210 220 230 240 WPRDLPGGVI HADLFTDNVF FIGDAVSGLI DFYFACTDAF AYDLAICLNA WCFELDGSFN 250 260 270 280 290 300 RTKGQAMIAA YQAARPLDPR EVESLPLLAR GAALRFMLTR LVDWLNVPPG ALVKPKDPLE 310 320 YDRKLAFHRR VTGAEEYGWT P

References

[1]

"Complete sequence of chromosome of Methylobacterium sp. 4-46." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Ivanova N., Marx C.J., Richardson P. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 4-46.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000943 Genomic DNA. Translation: ACA20303.1.
RefSeq	YP_001772737.1. NC_010511.1.
3D structure databases
ProteinModelPortal	B0UKH0.
SMR	B0UKH0. Positions 5-319.
ModBase	Search...
Protein-protein interaction databases
STRING	B0UKH0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6135926.
GenomeReviews	Gene locus M446_6026 in contig CP000943_GR.
KEGG	met:M446_6026.
PATRIC	22593320. VBIMetSp32184_5968.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	CLSK2331237.
Enzyme and pathway databases
BioCyc	MSP409:M446_6026-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_METS4

Accession

Primary (citable) accession number: B0UKH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program