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B0UKC4

- PUR5_METS4

UniProt

B0UKC4 - PUR5_METS4

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Methylobacterium sp. (strain 4-46)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMSP426117:GI2I-5219-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:M446_5164
    OrganismiMethylobacterium sp. (strain 4-46)
    Taxonomic identifieri426117 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000001185: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000193032Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi426117.M446_5164.

    Structurei

    3D structure databases

    ProteinModelPortaliB0UKC4.
    SMRiB0UKC4. Positions 47-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiISAHEMH.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0UKC4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGENGLTYA AAGVDIDAGN AMVEAIKPLV RSTRRPGADA EIGGFGGLFD    50
    LKAAGFSDPI LVAANDGVGT KVKIAIETGR HDTIGIDLVA MCVNDIVVQG 100
    AEPLFFLDYY ATGKLVPGVG AAIVTGIAEG CRQAGCALIG GETAEMPGLY 150
    DGSDYDLAGF AVGAAERGAL LPTDGVAPGD LVLGLPSSGV HSNGFSLVRR 200
    IVSASGLPWD APAPFAPGRS LGEALLTPTR IYVRPLLAAL RATGRGAIKA 250
    LAHITGGGFP DNLPRVLPEA VGIALDLDAV AVPPVFGWLA RTGGVAVPEM 300
    LRTFNCGIGM VVVVAPERIE AVEAALRAAG EAPVRLGTVT PRGEAPVSFA 350
    GRLGL 355
    Length:355
    Mass (Da):35,906
    Last modified:April 8, 2008 - v1
    Checksum:i9964F85347717E00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000943 Genomic DNA. Translation: ACA19489.1.
    RefSeqiWP_012334875.1. NC_010511.1.
    YP_001771923.1. NC_010511.1.

    Genome annotation databases

    EnsemblBacteriaiACA19489; ACA19489; M446_5164.
    GeneIDi6130754.
    KEGGimet:M446_5164.
    PATRICi22591518. VBIMetSp32184_5079.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000943 Genomic DNA. Translation: ACA19489.1 .
    RefSeqi WP_012334875.1. NC_010511.1.
    YP_001771923.1. NC_010511.1.

    3D structure databases

    ProteinModelPortali B0UKC4.
    SMRi B0UKC4. Positions 47-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 426117.M446_5164.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA19489 ; ACA19489 ; M446_5164 .
    GeneIDi 6130754.
    KEGGi met:M446_5164.
    PATRICi 22591518. VBIMetSp32184_5079.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi ISAHEMH.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci MSP426117:GI2I-5219-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 4-46.

    Entry informationi

    Entry nameiPUR5_METS4
    AccessioniPrimary (citable) accession number: B0UKC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3