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B0UI81

- SYR_METS4

UniProt

B0UI81 - SYR_METS4

Protein

Arginine--tRNA ligase

Gene

argS

Organism
Methylobacterium sp. (strain 4-46)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

    GO - Molecular functioni

    1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMSP426117:GI2I-2493-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
    Alternative name(s):
    Arginyl-tRNA synthetaseUniRule annotation
    Short name:
    ArgRSUniRule annotation
    Gene namesi
    Name:argSUniRule annotation
    Ordered Locus Names:M446_2480
    OrganismiMethylobacterium sp. (strain 4-46)
    Taxonomic identifieri426117 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000001185: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 586586Arginine--tRNA ligasePRO_1000198923Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi426117.M446_2480.

    Structurei

    3D structure databases

    ProteinModelPortaliB0UI81.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi130 – 14011"HIGH" regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0018.
    HOGENOMiHOG000247214.
    KOiK01887.
    OMAiPRVKGAI.
    OrthoDBiEOG6JB13C.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00123. Arg_tRNA_synth.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR11956. PTHR11956. 1 hit.
    PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR01038. TRNASYNTHARG.
    SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsiTIGR00456. argS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0UI81-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIFAAFEER IGEALATLTR AGQLPEGLDL GRVVVEPPRD PGHGDLATNA    50
    ALVLAKEART NPKALAELLA AELRQDPRVT EASVAGPGFL NLRLAPEVFA 100
    EVVRAALASG EAFGRGARRP GLVNVEYVSA NPTGPMHVGH GRGAVFGDAL 150
    ANLLAASGRE VVREYYINDA GAQVDVLARS AYLRYREALG DAIGAIPEGL 200
    YPGDYLKPVG RRLAETHGRA LLREPESAWL PVVRDFAIAA MMDLIRDDLA 250
    ALGIRHDVFF SERTLQGGGD GGAVGALIAE LREKGLVYVG RLPPPKGQLP 300
    EDWEDRDQTL FRSTAFGDDI DRPLLKSDGT YTYFASDIAY HASKVARGAT 350
    DLIDVLGADH GGYVKRMQAA VRAVSDGRAS LDVKLCQLVR LLRGGEPVKM 400
    SKRAGEFVTL REVIDEVGRD PVRFMMLYRK NDATLDFDLA KVVEQSKDNP 450
    VFYVQYAHAR TASVFRQARE AFPGEDLSPQ ALAGADLSLL RDSGEADIMR 500
    LVAQYPRVIE AAGSAHEPHR LAFYLYELAS AFHSFWNKGK DLPQLRFVNQ 550
    TDRKSTLSRL ALVAALRGVL ASGLGILGVT APDEMR 586
    Length:586
    Mass (Da):63,543
    Last modified:April 8, 2008 - v1
    Checksum:i641F3C68F63D7130
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000943 Genomic DNA. Translation: ACA16932.1.
    RefSeqiWP_012332339.1. NC_010511.1.
    YP_001769366.1. NC_010511.1.

    Genome annotation databases

    EnsemblBacteriaiACA16932; ACA16932; M446_2480.
    GeneIDi6129030.
    KEGGimet:M446_2480.
    PATRICi22586210. VBIMetSp32184_2465.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000943 Genomic DNA. Translation: ACA16932.1 .
    RefSeqi WP_012332339.1. NC_010511.1.
    YP_001769366.1. NC_010511.1.

    3D structure databases

    ProteinModelPortali B0UI81.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 426117.M446_2480.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA16932 ; ACA16932 ; M446_2480 .
    GeneIDi 6129030.
    KEGGi met:M446_2480.
    PATRICi 22586210. VBIMetSp32184_2465.

    Phylogenomic databases

    eggNOGi COG0018.
    HOGENOMi HOG000247214.
    KOi K01887.
    OMAi PRVKGAI.
    OrthoDBi EOG6JB13C.

    Enzyme and pathway databases

    BioCyci MSP426117:GI2I-2493-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.30.1360.70. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00123. Arg_tRNA_synth.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR001278. Arg-tRNA-ligase.
    IPR005148. Arg-tRNA-synth_N.
    IPR008909. DALR_anticod-bd.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR11956. PTHR11956. 1 hit.
    Pfami PF03485. Arg_tRNA_synt_N. 1 hit.
    PF05746. DALR_1. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR01038. TRNASYNTHARG.
    SMARTi SM01016. Arg_tRNA_synt_N. 1 hit.
    SM00836. DALR_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF55190. SSF55190. 1 hit.
    TIGRFAMsi TIGR00456. argS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 4-46.

    Entry informationi

    Entry nameiSYR_METS4
    AccessioniPrimary (citable) accession number: B0UI81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3