B0UHD7 (B0UHD7_METS4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut EMBL ACA19363.1
EC=3.6.1.23 EMBL ACA19363.1

Gene names

Ordered Locus Names:

M446_5036

Organism

Methylobacterium sp. (strain 4-46) [Complete proteome] [HAMAP]

Taxonomic identifier

426117 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length	162 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. SAAS SAAS008181
Catalytic activity	dUTP + H2O = dUMP + diphosphate. SAAS SAAS008181
Cofactor	Magnesium By similarity. SAAS SAAS008181

Ontologies

Keywords
Biological process	Nucleotide metabolism SAAS SAAS008181
Ligand	Magnesium SAAS SAAS008181 Metal-binding SAAS SAAS008181
Molecular function	Hydrolase SAAS SAAS008181 EMBL ACA19363.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B0UHD7 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: F47B5F8DDCD6F18B	FASTA	162	16,983
	10 20 30 40 50 60 MTGPDDLAVE IRLLDPRLSG WGFPRWGSAQ AAGLDLHACL DAPLTLAPQA APVLVPAGFA 70 80 90 100 110 120 VAIRDPGWCG LVCPRSGLGH REGLVLGNTV GVIDADYEGP LMLSLWNRNP PGASRPLTIA 130 140 150 160 PGERVAQLVF TRVTRPALRL VETFSGEAAA RGESGFGSTG RH

References

[1]

"Complete sequence of chromosome of Methylobacterium sp. 4-46." Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Ivanova N., Marx C.J., Richardson P. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 4-46.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000943 Genomic DNA. Translation: ACA19363.1.
RefSeq	YP_001771797.1. NC_010511.1.
3D structure databases
ProteinModelPortal	B0UHD7.
ModBase	Search...
Protein-protein interaction databases
STRING	B0UHD7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6129478.
GenomeReviews	Gene locus M446_5036 in contig CP000943_GR.
KEGG	met:M446_5036.
PATRIC	22591248. VBIMetSp32184_4944.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG436079.
OMA	LDLRACI.
ProtClustDB	CLSK2330713.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. IPR008181. dUTP_pyroPase_sf. [Graphical view]
KO	K01520.
PANTHER	PTHR11241. PTHR11241. 1 hit.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00576. Dut. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B0UHD7_METS4

Accession

Primary (citable) accession number: B0UHD7

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)