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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Methylobacterium sp. (strain 4-46)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:M446_0258
OrganismiMethylobacterium sp. (strain 4-46)
Taxonomic identifieri426117 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000001185 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 47HelicalUniRule annotationAdd BLAST21
Transmembranei72 – 92HelicalUniRule annotationAdd BLAST21
Transmembranei99 – 119HelicalUniRule annotationAdd BLAST21
Transmembranei139 – 159HelicalUniRule annotationAdd BLAST21
Transmembranei169 – 189HelicalUniRule annotationAdd BLAST21
Transmembranei200 – 220HelicalUniRule annotationAdd BLAST21
Transmembranei240 – 260HelicalUniRule annotationAdd BLAST21
Transmembranei264 – 284HelicalUniRule annotationAdd BLAST21
Transmembranei289 – 309HelicalUniRule annotationAdd BLAST21
Transmembranei338 – 358HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000906451 – 361Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST361

Interactioni

Protein-protein interaction databases

STRINGi426117.M446_0258.

Structurei

3D structure databases

SMRiB0UFH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B0UFH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYLLSELSG VFSPFNVFRY ITFRTGGALF TAGLFVFWFG PWIISLLRLR
60 70 80 90 100
QGKGQPIRED GPQTHLLTKR GTPTMGGLMI LAGLLVAVFL WANPRNSYVW
110 120 130 140 150
ITVVVTLGFG AIGFYDDYLK VTKQSHKGFS GKFRLGLEAL IAVAACVAVA
160 170 180 190 200
EYSAPGLAYR LAFPVFKDAI VNLGLFWIFF ASFVIVGAGN AVNITDGLDG
210 220 230 240 250
LAIVPVMIAA ATFGIIAYLV GNVIYASYLQ VNYVPGTGEL AVVCGALIGA
260 270 280 290 300
GLGFLWFNAP PAQIFMGDTG SLALGGLLGT VAVATKHEIV LAVVGGLFVL
310 320 330 340 350
EIASVIIQVA SFKLTGKRVF RMAPIHHHFE QKGWKEPQVV IRFWIIAVVL
360
ALLGLATLKL R
Length:361
Mass (Da):38,875
Last modified:April 8, 2008 - v1
Checksum:i8290BE0B016502EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000943 Genomic DNA. Translation: ACA14829.1.
RefSeqiWP_012330247.1. NC_010511.1.

Genome annotation databases

EnsemblBacteriaiACA14829; ACA14829; M446_0258.
KEGGimet:M446_0258.

Similar proteinsi

Entry informationi

Entry nameiMRAY_METS4
AccessioniPrimary (citable) accession number: B0UFH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: August 30, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families