B0UDF4 (URED_METS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Urease accessory protein UreD

Gene names

Name:	ureD
Ordered Locus Names:	M446_2214

Organism

Methylobacterium sp. (strain 4-46) [Complete proteome] [HAMAP]

Taxonomic identifier

426117 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter By similarity. HAMAP MF_01384
Subunit structure	UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_01384.
Sequence similarities	Belongs to the UreD family.

Ontologies

Keywords
Biological process	Nickel insertion
Cellular component	Cytoplasm
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	Urease accessory protein UreD HAMAP MF_01384		PRO_0000346580

Sequences

	Sequence		Length	Mass (Da)
	B0UDF4 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 576B70D541414455	FASTA	282	29,577
	10 20 30 40 50 60 MSSHPTPSWP RRQRSEGRVA LGAGLVAGGT TRLTDLAETG PLRLRLPRVE GAALEGVLLN 70 80 90 100 110 120 SAGGLACGDR FAVAAEIGEG ADMVLTTTAA EKIYRSDGPV TEIAAELRLG PRARLAWLPQ 130 140 150 160 170 180 ETILYDGARL SRRLTAEIAP DAALTLFEAL VFGRSARGET VREGEIRDAW RLARGGRLVY 190 200 210 220 230 240 ADTLRLDGAV AAHLARPAIA GGARAVATLV HAAPDAESRL DGLRGLIAAA GCAALGVEAG 250 260 270 280 ASAWNGLLVL RLLAPESAPL RRAATRILEG FRGLPLPRVW QT

References

[1]

"Complete sequence of chromosome of Methylobacterium sp. 4-46." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Ivanova N., Marx C.J., Richardson P. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 4-46.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000943 Genomic DNA. Translation: ACA16675.1.
RefSeq	YP_001769109.1. NC_010511.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B0UDF4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6132956.
GenomeReviews	Gene locus M446_2214 in contig CP000943_GR.
KEGG	met:M446_2214.
PATRIC	22585656. VBIMetSp32184_2190.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG711156.
OMA	QETILFD.
ProtClustDB	CLSK980186.
Enzyme and pathway databases
BioCyc	MSP409:M446_2214-MONOMER.
Family and domain databases
HAMAP	MF_01384. UreD. [Tree]
InterPro	IPR002669. UreD. [Graphical view]
KO	K03190.
Pfam	PF01774. UreD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

URED_METS4

Accession

Primary (citable) accession number: B0UDF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program