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B0UAS8 (B0UAS8_METS4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Choline dehydrogenase HAMAP MF_00750
Short name=CDH HAMAP MF_00750
Short name=CHD HAMAP MF_00750
EC=1.1.99.1 HAMAP MF_00750
Gene names
Name:betA HAMAP MF_00750
Ordered Locus Names:M446_4716
OrganismMethylobacterium sp. (strain 4-46) [Complete proteome] [HAMAP]
Taxonomic identifier426117 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750 SAAS SAAS007867

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750 RuleBase RU003969 SAAS SAAS007867

Cofactor

FAD By similarity. HAMAP MF_00750 SAAS SAAS007867 RuleBase RU003968

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750 RuleBase RU003969 SAAS SAAS007867

Sequence similarities

Belongs to the GMC oxidoreductase family. HAMAP MF_00750 RuleBase RU003968

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding6 – 3530FAD By similarity HAMAP MF_00750

Sites

Active site4741 By similarity HAMAP MF_00750

Sequences

Sequence LengthMass (Da)Tools
B0UAS8 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: F2C3DBC4A91D71A1

FASTA56161,606
        10         20         30         40         50         60 
MTQEYDFIIV GAGSAGNVLA ARLTEDADVS VLLLEAGGPD YRFDFRTQMP AALAYPLQGR 

        70         80         90        100        110        120 
RYNWAYLTDP EPHMNNRRME CGRGKGLGGS SLINGMCYIR GNPLDYDGWA RLPSLADWSY 

       130        140        150        160        170        180 
GDCLPYFRRA ETRDLGPDTY HGGDGPLYVT AAKPGGNVLF EAMIEAGVQA GYPRTADLNG 

       190        200        210        220        230        240 
YQQEGFGPMD RSVTAKGRRS STARGYLDQA RERPNLTIVT HALTDRILFN GKRASGVVYL 

       250        260        270        280        290        300 
RGNKEPSFAR ARREVLVCSG AIASPQILQR SGVGPANLLR NLDVPLVLDL PGVGENLQDH 

       310        320        330        340        350        360 
LEMYVQYECR QPVSLAPALK PWNQPAIGAR WLFAGTGIGA SNQFEAGGFI RSDSEFAWPN 

       370        380        390        400        410        420 
LQYHFLPLAI SYNGSHAVKS HSFQAHVGSM RSPSRGRIRL TSRDPHAHPS ILFNYMSADQ 

       430        440        450        460        470        480 
DWREFRVAIR ITREIMAQPA LDPYRGREIS PGAALRSDAE LDAFVRAHAE TAYHPSCSCK 

       490        500        510        520        530        540 
MGEDAMAVVD GRGRVHGLEG LRVVDASIMP QIVTGNLNAP TIMIAEKIAD DIRGRTPLPR 

       550        560 
SQAAYFVAGD TPPRRRPVRA S

« Hide

References

[1]"Complete sequence of chromosome of Methylobacterium sp. 4-46."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Ivanova N., Marx C.J., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 4-46.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000943 Genomic DNA. Translation: ACA19052.1.
RefSeqYP_001771486.1. NC_010511.1.

3D structure databases

ProteinModelPortalB0UAS8.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0UAS8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6130958.
GenomeReviewsGene locus M446_4716 in contig CP000943_GR.
KEGGmet:M446_4716.
PATRIC22590622. VBIMetSp32184_4634.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG734713.
OMARSTAPYY.
ProtClustDBPRK02106.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
[Tree]
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
KOK00108.
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. BetA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB0UAS8_METS4
AccessionPrimary (citable) accession number: B0UAS8
Entry history
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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