B0UAJ8 (AHPD_METS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkyl hydroperoxide reductase AhpD
EC=1.11.1.15

Alternative name(s):
Alkylhydroperoxidase AhpD

Gene names

Name:	ahpD
Ordered Locus Names:	M446_3530

Organism

Methylobacterium sp. (strain 4-46) [Complete proteome] [HAMAP]

Taxonomic identifier

426117 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Methylobacteriaceae › Methylobacterium

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity. HAMAP MF_01676
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Sequence similarities	Belongs to the AhpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Alkyl hydroperoxide reductase AhpD HAMAP MF_01676		PRO_0000359494
Sites
	Active site	131	1	Proton donor By similarity
	Active site	134	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	131 ↔ 134		Alternate By similarity
	Disulfide bond	134		Interchain (with AhpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0UAJ8 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: BCB6EE04CF4F3BBB	FASTA	176	18,401
	10 20 30 40 50 60 MTLDALLQSL PPYAKDVRLN FSSLGREETL TAQQRDGLLV ACGLASRNPD LARALEAEAA 70 80 90 100 110 120 PRLSPAALAA AKAAATVMAM NNVYYRFTHL ASNPAYATRP AKLRMSSIGN PGVARADFEL 130 140 150 160 170 WSLAVSAING CGRCIDAHEQ VLREAGVGEE AIQAAVRVAA VVASLAVALE SVRAAA

References

[1]

"Complete sequence of chromosome of Methylobacterium sp. 4-46." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Ivanova N., Marx C.J., Richardson P. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 4-46.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000943 Genomic DNA. Translation: ACA17913.1.
RefSeq	YP_001770347.1. NC_010511.1.
3D structure databases
ProteinModelPortal	B0UAJ8.
ModBase	Search...
Protein-protein interaction databases
STRING	B0UAJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6131762.
GenomeReviews	Gene locus M446_3530 in contig CP000943_GR.
KEGG	met:M446_3530.
PATRIC	22588291. VBIMetSp32184_3489.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG414634.
OMA	RAGLRMN.
Enzyme and pathway databases
BioCyc	MSP409:M446_3530-MONOMER.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
KO	K04756.
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. AhpD. 1 hit. TIGR00778. AhpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_METS4

Accession

Primary (citable) accession number: B0UAJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program