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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

M446_6300

Organism
Methylobacterium sp. (strain 4-46)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase
Biological processGlycolysisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Ordered Locus Names:M446_6300Imported
OrganismiMethylobacterium sp. (strain 4-46)Imported
Taxonomic identifieri426117 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000001185 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

Protein-protein interaction databases

STRINGi426117.M446_6300

Structurei

3D structure databases

ProteinModelPortaliB0U862
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 76Lipoyl-bindingInterPro annotationAdd BLAST75
Domaini141 – 178Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QSN Bacteria
COG0508 LUCA
HOGENOMiHOG000281562
KOiK00627
OMAiFTPIFME
OrthoDBiPOG091H05OF

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR006256 AcTrfase_Pyrv_DH_cplx
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PANTHERiPTHR43178:SF2 PTHR43178:SF2, 2 hits
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 1 hit
TIGRFAMsiTIGR01348 PDHac_trf_long, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00189 LIPOYL, 1 hit
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

B0U862-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEVKVPDI GDFKDVPIIE VHVKEGDTIG PDDPIISLES DKATMEVPAP
60 70 80 90 100
SGGVVEKLLI KIGDKVSEGH PILLLKGEGD AKGDATSAPR SESESKGNGA
110 120 130 140 150
APADTAALIA KQEPPESAAP PAPVPAPAAS GAGIPDFSQI HASPAVRRLA
160 170 180 190 200
RELGVDLNAI KGTGEKGRIT KEDVKGHLTR SAAPAPSGAV FAGGGMGIPE
210 220 230 240 250
IPAVDFSKFG PTETKPLARI KKISGPHLHR AWLNVPLVTH QDEADITETE
260 270 280 290 300
AYRKDLDKTA KDKGYRVTLL AFLIKASVSA LRQHPEFNAS LSPDKEALIL
310 320 330 340 350
KRYYNIGVAV DTPDGLVVPV VKDADRKGIG EISQELGALS KKARDGKLGS
360 370 380 390 400
GDMQGASFTI SSLGGIGGTA FTPLVNAPEV AILGVVRSRM APVWDGSEFK
410 420 430 440
PRLMLPLSVS YDHRVIDGAL AARFTRHLAH VLEDVRRLVI
Length:440
Mass (Da):46,287
Last modified:April 8, 2008 - v1
Checksum:i5ECC6C0985075A9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000943 Genomic DNA Translation: ACA20566.1
RefSeqiWP_012335944.1, NC_010511.1

Genome annotation databases

EnsemblBacteriaiACA20566; ACA20566; M446_6300
KEGGimet:M446_6300

Similar proteinsi

Entry informationi

Entry nameiB0U862_METS4
AccessioniPrimary (citable) accession number: B0U862
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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