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B0U862

- B0U862_METS4

UniProt

B0U862 - B0U862_METS4

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

M446_6300

Organism
Methylobacterium sp. (strain 4-46)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotation

    Enzyme and pathway databases

    BioCyciMSP426117:GI2I-6376-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Ordered Locus Names:M446_6300Imported
    OrganismiMethylobacterium sp. (strain 4-46)Imported
    Taxonomic identifieri426117 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000001185: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Subunit structurei

    Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

    Protein-protein interaction databases

    STRINGi426117.M446_6300.

    Structurei

    3D structure databases

    ProteinModelPortaliB0U862.
    SMRiB0U862. Positions 3-81, 139-183, 198-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 lipoyl-binding domain.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0508.
    HOGENOMiHOG000281562.
    KOiK00627.
    OMAiFWHVSEG.
    OrthoDBiEOG610413.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0U862-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATEVKVPDI GDFKDVPIIE VHVKEGDTIG PDDPIISLES DKATMEVPAP    50
    SGGVVEKLLI KIGDKVSEGH PILLLKGEGD AKGDATSAPR SESESKGNGA 100
    APADTAALIA KQEPPESAAP PAPVPAPAAS GAGIPDFSQI HASPAVRRLA 150
    RELGVDLNAI KGTGEKGRIT KEDVKGHLTR SAAPAPSGAV FAGGGMGIPE 200
    IPAVDFSKFG PTETKPLARI KKISGPHLHR AWLNVPLVTH QDEADITETE 250
    AYRKDLDKTA KDKGYRVTLL AFLIKASVSA LRQHPEFNAS LSPDKEALIL 300
    KRYYNIGVAV DTPDGLVVPV VKDADRKGIG EISQELGALS KKARDGKLGS 350
    GDMQGASFTI SSLGGIGGTA FTPLVNAPEV AILGVVRSRM APVWDGSEFK 400
    PRLMLPLSVS YDHRVIDGAL AARFTRHLAH VLEDVRRLVI 440
    Length:440
    Mass (Da):46,287
    Last modified:April 8, 2008 - v1
    Checksum:i5ECC6C0985075A9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000943 Genomic DNA. Translation: ACA20566.1.
    RefSeqiWP_012335944.1. NC_010511.1.
    YP_001773000.1. NC_010511.1.

    Genome annotation databases

    EnsemblBacteriaiACA20566; ACA20566; M446_6300.
    GeneIDi6135502.
    KEGGimet:M446_6300.
    PATRICi22593891. VBIMetSp32184_6245.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000943 Genomic DNA. Translation: ACA20566.1 .
    RefSeqi WP_012335944.1. NC_010511.1.
    YP_001773000.1. NC_010511.1.

    3D structure databases

    ProteinModelPortali B0U862.
    SMRi B0U862. Positions 3-81, 139-183, 198-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 426117.M446_6300.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA20566 ; ACA20566 ; M446_6300 .
    GeneIDi 6135502.
    KEGGi met:M446_6300.
    PATRICi 22593891. VBIMetSp32184_6245.

    Phylogenomic databases

    eggNOGi COG0508.
    HOGENOMi HOG000281562.
    KOi K00627.
    OMAi FWHVSEG.
    OrthoDBi EOG610413.

    Enzyme and pathway databases

    BioCyci MSP426117:GI2I-6376-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 4-46Imported.

    Entry informationi

    Entry nameiB0U862_METS4
    AccessioniPrimary (citable) accession number: B0U862
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3