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B0U7A0

- PUR9_XYLFM

UniProt

B0U7A0 - PUR9_XYLFM

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Xylella fastidiosa (strain M12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciXFAS405440:GH0D-1026-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:Xfasm12_0998
OrganismiXylella fastidiosa (strain M12)
Taxonomic identifieri405440 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
ProteomesiUP000008539: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Bifunctional purine biosynthesis protein PurHPRO_1000096110Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi405440.Xfasm12_0998.

Structurei

3D structure databases

ProteinModelPortaliB0U7A0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B0U7A0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASDFLPVHR ALLSVSDKTG LVELARVLLA YNIELLSTGG TATIIREAGL
60 70 80 90 100
PVQDVADLTG FPEMMDGRVK TLHPVVHGGL LGRAGIDDAV MAKHGIAPID
110 120 130 140 150
LLILNLYPFE QITAKKDCTL ADAVDTIDIG GPAMLRSAAK NFARVAVATS
160 170 180 190 200
PDQYPDLLAE LQEHHGQLSA EKRFALAVAA FNHVAQYDAA ISNYLSSVSD
210 220 230 240 250
MHTTLPLRHE FPAQLNNTFV KMTELRYGEN PHQTGAFYRD VHPQPGTLAT
260 270 280 290 300
FQQLQGKRLS YNNLVDADAA WECVRQFEAP ACVIVKHANP CGVAVGMACS
310 320 330 340 350
DAYEAAYATD PTSAFGGIIA FNRTLDAVTM KSILDRQFVE VFIAPYYDAD
360 370 380 390 400
ALAYAAKKAN VRVLRIPSSA AMKATNQYDF KRIGSGLLVQ SADTMHIHSD
410 420 430 440 450
VLRTVTTLAP TDKQRRDLMF AWRVVKYVKS NAIVYAKDNR TIGIGAGQMS
460 470 480 490 500
RVYSARIAGI KAADAHLAVT GSVMASDAFF PFRDGIDAAA ATGIKAVIQP
510 520 530
GGSMRDNEVI AAADEHGIAM LFTGIRHFRH
Length:530
Mass (Da):57,304
Last modified:April 8, 2008 - v1
Checksum:iD2C73AE7348AB03E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000941 Genomic DNA. Translation: ACA11966.1.
RefSeqiYP_001775596.1. NC_010513.1.

Genome annotation databases

EnsemblBacteriaiACA11966; ACA11966; Xfasm12_0998.
GeneIDi6121482.
KEGGixfm:Xfasm12_0998.
PATRICi24138453. VBIXylFas124301_1182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000941 Genomic DNA. Translation: ACA11966.1 .
RefSeqi YP_001775596.1. NC_010513.1.

3D structure databases

ProteinModelPortali B0U7A0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405440.Xfasm12_0998.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA11966 ; ACA11966 ; Xfasm12_0998 .
GeneIDi 6121482.
KEGGi xfm:Xfasm12_0998.
PATRICi 24138453. VBIXylFas124301_1182.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci XFAS405440:GH0D-1026-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23) causing almond leaf scorch disease in California."
    Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.
    J. Bacteriol. 192:4534-4534(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M12.

Entry informationi

Entry nameiPUR9_XYLFM
AccessioniPrimary (citable) accession number: B0U7A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3