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B0U741

- GCH4_XYLFM

UniProt

B0U741 - GCH4_XYLFM

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Protein

GTP cyclohydrolase FolE2

Gene
folE2, Xfasm12_0929
Organism
Xylella fastidiosa (strain M12)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei155 – 1551May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciXFAS405440:GH0D-957-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:Xfasm12_0929
OrganismiXylella fastidiosa (strain M12)
Taxonomic identifieri405440 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
ProteomesiUP000008539: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298GTP cyclohydrolase FolE2UniRule annotationPRO_0000372038Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi405440.Xfasm12_0929.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0U741-1 [UniParc]FASTAAdd to Basket

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MSTSIPDVAV HDSPAIAAPL RWVGMDGIVV PVQLTIADGG QHVIGRARAQ    50
IDLPAMEVKG IHMSRLYRLL DTHAVEPLTP VGICGLLSAM VNSHADCAST 100
AARVDWYFDW LRRVPALVSN DLSGWRGYPV WLRAEYSAGH VQFWLCVEVG 150
YSSTCPCSAA LARQMLADAF LQEHVEVSAL SPETVADWLR SNGSYATPHS 200
QRSLARIEVA LTEQAVELGL PALVDCAERI LSTPVQAAVR RVDEQAFARL 250
NGANLMYVED ATRRLQHGLA IHYSAFRVHV RHLESLHPHD AVASTADE 298
Length:298
Mass (Da):32,583
Last modified:May 5, 2009 - v2
Checksum:i2104418A31A1C556
GO

Sequence cautioni

The sequence ACA11907.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000941 Genomic DNA. Translation: ACA11907.1. Different initiation.
RefSeqiYP_001775537.1. NC_010513.1.

Genome annotation databases

EnsemblBacteriaiACA11907; ACA11907; Xfasm12_0929.
GeneIDi6120788.
KEGGixfm:Xfasm12_0929.
PATRICi24138295. VBIXylFas124301_1103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000941 Genomic DNA. Translation: ACA11907.1 . Different initiation.
RefSeqi YP_001775537.1. NC_010513.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405440.Xfasm12_0929.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA11907 ; ACA11907 ; Xfasm12_0929 .
GeneIDi 6120788.
KEGGi xfm:Xfasm12_0929.
PATRICi 24138295. VBIXylFas124301_1103.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci XFAS405440:GH0D-957-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23) causing almond leaf scorch disease in California."
    Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.
    J. Bacteriol. 192:4534-4534(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M12.

Entry informationi

Entry nameiGCH4_XYLFM
AccessioniPrimary (citable) accession number: B0U741
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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