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Protein

Catalase-peroxidase

Gene

katG

Organism
Xylella fastidiosa (strain M12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei98 – 981Transition state stabilizerUniRule annotation
Active sitei102 – 1021Proton acceptorUniRule annotation
Metal bindingi289 – 2891Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciXFAS405440:GH0D-1466-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Xfasm12_1432
OrganismiXylella fastidiosa (strain M12)
Taxonomic identifieri405440 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Catalase-peroxidasePRO_0000354960Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki101 ↔ 248Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-274)UniRule annotation
Cross-linki248 ↔ 274Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-101)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0U3C6.
SMRiB0U3C6. Positions 26-756.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0U3C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDMRASSPE TTSAVKCPFN KTAVEGTHNK DWWPNQLRVD LLHQHSNKSN
60 70 80 90 100
PLGETFDYAK VFQKLDYAAL KRDLHALMTD SQDWWPADFG HYGGLFIRMA
110 120 130 140 150
WHSAGTYRIG DGRGGAGRGQ QRFAPLNSWP DNVSLDKARR LLWPIKKKYG
160 170 180 190 200
QQISWADLIV LAGNVALESM GFKTFGFAGG RVDTWEPDQD VYWGREMTWL
210 220 230 240 250
GGDVRYGAVS EGVHHPDEHS GAKEKASKNS DSRVLENPLA AVQMGLIYVN
260 270 280 290 300
PEGPDGRPDP LASARDIRET FARMAMNDEE TVALIAGGHT FGKTHGAAPA
310 320 330 340 350
DNVGPEPEAG ELEQQGLGWH NRFGSGKAGD TITSGLEVTW TKTPTQWSND
360 370 380 390 400
FFEHLFGYEW ELTKSPAGAY QWVAKDAAAT IPHAHDPSKK LLPMMLTSDL
410 420 430 440 450
ALRFDPVYEK ISRHFHAHPD QFADAFARAW FKLTHRDMGP RVRYLGPEVP
460 470 480 490 500
AEELIWQDPV PKVSHVLVDA QDLLALKHKI SASGLGISQL VSTAWASAST
510 520 530 540 550
FRGSDKRGGA NGGRLCLAPQ NQWEVNQPQQ LSVVLETLRR VQTEFNAQAG
560 570 580 590 600
DKRISLADLI VLAGGVGVEQ AAKRVGIVVE VPFVPGRTDA LQEQTDVSSF
610 620 630 640 650
APLEPFADGF RNYVKGDEVV PSEHLLIDRA QLLTLTAPEM TVLIGGLRVL
660 670 680 690 700
GANVGGVKHG VFTDRLGTLS NDFFINLLDM GTEWAPVSKE RHVFEGRDRR
710 720 730 740 750
TGVLKWTGTR VDLVFGSNAL LRALAEVYAA VDAQEKFVRD FVAAWSKVMH

LDRFDLV
Length:757
Mass (Da):83,696
Last modified:April 8, 2008 - v1
Checksum:iFF3F0016FE1146F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000941 Genomic DNA. Translation: ACA12355.1.

Genome annotation databases

EnsemblBacteriaiACA12355; ACA12355; Xfasm12_1432.
KEGGixfm:Xfasm12_1432.
PATRICi24139453. VBIXylFas124301_1675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000941 Genomic DNA. Translation: ACA12355.1.

3D structure databases

ProteinModelPortaliB0U3C6.
SMRiB0U3C6. Positions 26-756.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA12355; ACA12355; Xfasm12_1432.
KEGGixfm:Xfasm12_1432.
PATRICi24139453. VBIXylFas124301_1675.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.

Enzyme and pathway databases

BioCyciXFAS405440:GH0D-1466-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_XYLFM
AccessioniPrimary (citable) accession number: B0U3C6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 8, 2008
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.