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Protein

Homoserine kinase

Gene

thrB

Organism
Xylella fastidiosa (strain M12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotation

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Homoserine kinase (thrB)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi107 – 11711ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXFAS405440:GH0D-1458-MONOMER.
UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:Xfasm12_1424
OrganismiXylella fastidiosa (strain M12)
Taxonomic identifieri405440 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Homoserine kinasePRO_1000122453Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB0U3B8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000247197.
KOiK00872.
OMAiVVEPCRA.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.

Sequencei

Sequence statusi: Complete.

B0U3B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRTLQPDSG ASQTAPTAHQ ARAFAPASVA NVAVGFDLLG YPMDQVGDTV
60 70 80 90 100
TVRRIDTPQV RIAAIRGIAQ PLPLQTERNT AGAALLSMHR DLALPFGFEL
110 120 130 140 150
EIDKGIPLSS GMGGSAASCV AALLAANALL DEPLRREHLY RYALDGEAVA
160 170 180 190 200
SGSRHGDNLG PLFLGGLVLC TLERLVPVTV PTAWHSLLVH PDTLLETRRA
210 220 230 240 250
REVLKEPYLL PDIVTQSANL ALVLAGCYHS DAELVRAGLR DVLIEPRRAP
260 270 280 290 300
LIAGFTAAQQ AALQADAMGA SISGAGPSVF AWFQTRSAAE AAAPAVRAAF
310 320
TAAGFDSQAW VTPLTSPGAR LL
Length:322
Mass (Da):33,806
Last modified:April 8, 2008 - v1
Checksum:iE1C19C598D0B33D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000941 Genomic DNA. Translation: ACA12347.1.
RefSeqiWP_004083414.1. NC_010513.1.

Genome annotation databases

EnsemblBacteriaiACA12347; ACA12347; Xfasm12_1424.
KEGGixfm:Xfasm12_1424.
PATRICi24139439. VBIXylFas124301_1668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000941 Genomic DNA. Translation: ACA12347.1.
RefSeqiWP_004083414.1. NC_010513.1.

3D structure databases

ProteinModelPortaliB0U3B8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA12347; ACA12347; Xfasm12_1424.
KEGGixfm:Xfasm12_1424.
PATRICi24139439. VBIXylFas124301_1668.

Phylogenomic databases

HOGENOMiHOG000247197.
KOiK00872.
OMAiVVEPCRA.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.
BioCyciXFAS405440:GH0D-1458-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23) causing almond leaf scorch disease in California."
    Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.
    J. Bacteriol. 192:4534-4534(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M12.

Entry informationi

Entry nameiKHSE_XYLFM
AccessioniPrimary (citable) accession number: B0U3B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: November 11, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.