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B0U376

- SYL_XYLFM

UniProt

B0U376 - SYL_XYLFM

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Protein
Leucine--tRNA ligase
Gene
leuS, Xfasm12_1376
Organism
Xylella fastidiosa (strain M12)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei640 – 6401ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXFAS405440:GH0D-1410-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Xfasm12_1376
OrganismiXylella fastidiosa (strain M12)
Taxonomic identifieri405440 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
ProteomesiUP000008539: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 879879Leucine--tRNA ligaseUniRule annotation
PRO_1000091381Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi405440.Xfasm12_1376.

Structurei

3D structure databases

ProteinModelPortaliB0U376.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 5511"HIGH" regionUniRule annotation
Add
BLAST
Motifi637 – 6415"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0U376-1 [UniParc]FASTAAdd to Basket

« Hide

MPTEANTYDP QRIESIAQHY WDSTHAFEVN EHSNKPKYYC LSMLPYPSGA    50
LHMGHVRNYT IGDVISRYKR MTGHNVLQPM GWDAFGLPAE NAAIKNKVAP 100
AQWTYKNIER MRTQLKSLGY AINWSREFAT CQPDYYVHEQ HMFTRLMRKG 150
LAYRRNALVN WDPVDQTVLA NEQVIDGRGW RSGAPVEKRE IPQWFLRITD 200
YAQELLDGLN TLDDWPEPVK TMQRNWIGRS EGLEIRFEVR DVDNNALEAL 250
RVFTTRPDTL FGVTFVSIAP EHPLALHAAK SNPGLAGLLT QMKQGGLSEA 300
ELKTQEKRGM DTGLKAIHPI TNEQLPVWVA NFVLMAYGTG AVMAVPGHDQ 350
RDQEFANKYG LPIRQVIALK EPKNQDESTW EPDVWRDWYA DKTREFELIN 400
SAEFDGLDYQ GAFEVLVERF ERQGRGQRRV NYRLRDWGVS RQRYWGCPIP 450
VIYCPTCGAV PVPENQLPVI LPENVAFSGT GSPIKTDSEW RKTTCPECGG 500
PAERETDTFD TFMESSWYYA RYTSPNAREM LDKRANYWLP VDQYIGGIEH 550
AILHLMYFRF YHKLMRDARL VDSDEPAINL LTQGMVIAET FYRKNPDGSK 600
DWINPADVNV ECDERGRITG ATLISDGQPV LIGATEKMSK SKNNGVDPQI 650
MVTKYGADTV RLFSMFAAPP EQSLEWNEAG VEGMARFLRR LWTQVHHHAS 700
HGPATALDIT ALDTAQKAIR CKTHNTIARV EDDYGRRRSF NTAIAAVMEL 750
SNTLARFDDT TTQSHAVRQE ALETMVLLLN PITPHTSHAL WQTLGHPETL 800
LEDLPFPKVD TTALVRETAT LAVQVNGKLR GTIEVATDAP REHIENNALT 850
EPNTARFLEG LTVLKIIIVP GKIVNIVAR 879
Length:879
Mass (Da):99,798
Last modified:April 8, 2008 - v1
Checksum:i9CF661FEC6FCB1C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000941 Genomic DNA. Translation: ACA12305.1.
RefSeqiYP_001775935.1. NC_010513.1.

Genome annotation databases

EnsemblBacteriaiACA12305; ACA12305; Xfasm12_1376.
GeneIDi6119897.
KEGGixfm:Xfasm12_1376.
PATRICi24139333. VBIXylFas124301_1615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000941 Genomic DNA. Translation: ACA12305.1 .
RefSeqi YP_001775935.1. NC_010513.1.

3D structure databases

ProteinModelPortali B0U376.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405440.Xfasm12_1376.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA12305 ; ACA12305 ; Xfasm12_1376 .
GeneIDi 6119897.
KEGGi xfm:Xfasm12_1376.
PATRICi 24139333. VBIXylFas124301_1615.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci XFAS405440:GH0D-1410-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23) causing almond leaf scorch disease in California."
    Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.
    J. Bacteriol. 192:4534-4534(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M12.

Entry informationi

Entry nameiSYL_XYLFM
AccessioniPrimary (citable) accession number: B0U376
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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