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B0U365 (GLO2_XYLFM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Hydroxyacylglutathione hydrolase
EC=3.1.2.6
Alternative name(s):
Glyoxalase II
Short name=Glx II
Gene names
Name:gloB
Ordered Locus Names:Xfasm12_1364
OrganismXylella fastidiosa (strain M12) [Complete proteome] [HAMAP]
Taxonomic identifier405440 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xylella

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid By similarity. HAMAP MF_01374

Catalytic activity

S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. HAMAP MF_01374

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_01374

Pathway

Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2. HAMAP MF_01374

Subunit structure

Monomer By similarity. HAMAP MF_01374

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionhydroxyacylglutathione hydrolase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Hydroxyacylglutathione hydrolase HAMAP MF_01374
PRO_1000144822

Sites

Metal binding521Zinc 1 By similarity
Metal binding541Zinc 1 By similarity
Metal binding561Zinc 2 By similarity
Metal binding571Zinc 2 By similarity
Metal binding1091Zinc 1 By similarity
Metal binding1261Zinc 1 By similarity
Metal binding1261Zinc 2 By similarity
Metal binding1641Zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
B0U365 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 6113A0FAE226C451

FASTA25828,477
        10         20         30         40         50         60 
MRLTPLPAFD NNYIWTLIAP DGRAIIVDPG QALPILEAHS KGLIPTAILL THHHADHIGG 

        70         80         90        100        110        120 
VPELLERWPT LPVYAPHDTR IALNYHRIGE GDSLNILGLR FQVIHTPGHT HSHLTFIGND 

       130        140        150        160        170        180 
LLFCGDTLFS LGCGQIFEGT PTQMLASLQR LAALPIQTRV CCGHEYTLSN AAFALHVDPT 

       190        200        210        220        230        240 
NTALQKRRQQ ANAMRLAGLP TLPISLESEL NTNPFLRTAA PTIHAATATH LQRTPIDEVE 

       250 
VFATLRHWKN NFPIKNIP

« Hide

References

[1]"Whole genome sequences of two Xylella fastidiosa strains (M12 and M23) causing almond leaf scorch disease in California."
Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.
J. Bacteriol. 192:4534-4534(2010) [PubMed: 20601474] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: M12.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000941 Genomic DNA. Translation: ACA12294.1.
RefSeqYP_001775924.1. NC_010513.1.

3D structure databases

ProteinModelPortalB0U365.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0U365.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6119885.
GenomeReviewsGene locus Xfasm12_1364 in contig CP000941_GR.
KEGGxfm:Xfasm12_1364.
PATRIC24139303. VBIXylFas124301_1600.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG753931.
OMAFLCRTDN.
ProtClustDBCLSK497122.

Enzyme and pathway databases

BioCycXFAS405440:XFASM12_1364-MONOMER.

Family and domain databases

HAMAPMF_01374. Glyoxalase_2.
[Tree]
InterProIPR001279. Beta-lactamas-like.
IPR017782. Hydroxyacylglutathione_Hdrlase.
[Graphical view]
KOK01069.
PANTHERPTHR11935:SF7. PTHR11935:SF7. 1 hit.
PfamPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTSM00849. Lactamase_B. 1 hit.
[Graphical view]
TIGRFAMsTIGR03413. GSH_gloB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLO2_XYLFM
AccessionPrimary (citable) accession number: B0U365
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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