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B0U236

- LPXB_XYLFM

UniProt

B0U236 - LPXB_XYLFM

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Xylella fastidiosa (strain M12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciXFAS405440:GH0D-371-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Xfasm12_0353
OrganismiXylella fastidiosa (strain M12)
Taxonomic identifieri405440 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
ProteomesiUP000008539: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Lipid-A-disaccharide synthasePRO_1000123070Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi405440.Xfasm12_0353.

Structurei

3D structure databases

ProteinModelPortaliB0U236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B0U236-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQAPRIALI AGEASGDHLG AGLIQQLRLH FPTAEFIGIG GDMMRSAGCQ
60 70 80 90 100
TWFDTTELAV MGLTEVLRHL PRLLKIRREF CKRALAWHPD VLIGIDAPDF
110 120 130 140 150
NLTVERWFKQ RHIRTVHYVS PSIWAWREKR AAKIGASVDR VLCLFPMEPP
160 170 180 190 200
IYARYGIDAR FVGHPMADEI PYQTDRATAR TALGLPLLSP VLAVLPGSRH
210 220 230 240 250
SEISQLGNTF LEAAGQLSEH LPGLHVVIPA ANTQCKPLLA EQLSRSTLPV
260 270 280 290 300
MHSHLLDSSA RTAMLAADVV LVASGTATLE AMLLKRPMVV AYKVAPLTYR
310 320 330 340 350
IVKTLKLLKI NRFALPNILA GEDLAPELIQ KDCTAPALCA ALLHWFKHPQ
360 370 380
KVTALQNRYL QLHTQLRRNA STRAAEAIAE LLQQR
Length:385
Mass (Da):42,674
Last modified:April 8, 2008 - v1
Checksum:i4B515510A9C24FC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000941 Genomic DNA. Translation: ACA11370.1.
RefSeqiYP_001775000.1. NC_010513.1.

Genome annotation databases

EnsemblBacteriaiACA11370; ACA11370; Xfasm12_0353.
GeneIDi6119560.
KEGGixfm:Xfasm12_0353.
PATRICi24136954. VBIXylFas124301_0441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000941 Genomic DNA. Translation: ACA11370.1 .
RefSeqi YP_001775000.1. NC_010513.1.

3D structure databases

ProteinModelPortali B0U236.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405440.Xfasm12_0353.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA11370 ; ACA11370 ; Xfasm12_0353 .
GeneIDi 6119560.
KEGGi xfm:Xfasm12_0353.
PATRICi 24136954. VBIXylFas124301_0441.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci XFAS405440:GH0D-371-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23) causing almond leaf scorch disease in California."
    Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.
    J. Bacteriol. 192:4534-4534(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M12.

Entry informationi

Entry nameiLPXB_XYLFM
AccessioniPrimary (citable) accession number: B0U236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3