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B0U236

- LPXB_XYLFM

UniProt

B0U236 - LPXB_XYLFM

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Xfasm12_0353
Organism
Xylella fastidiosa (strain M12)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciXFAS405440:GH0D-371-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Xfasm12_0353
OrganismiXylella fastidiosa (strain M12)
Taxonomic identifieri405440 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
ProteomesiUP000008539: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000123070Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi405440.Xfasm12_0353.

Structurei

3D structure databases

ProteinModelPortaliB0U236.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B0U236-1 [UniParc]FASTAAdd to Basket

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MIQAPRIALI AGEASGDHLG AGLIQQLRLH FPTAEFIGIG GDMMRSAGCQ    50
TWFDTTELAV MGLTEVLRHL PRLLKIRREF CKRALAWHPD VLIGIDAPDF 100
NLTVERWFKQ RHIRTVHYVS PSIWAWREKR AAKIGASVDR VLCLFPMEPP 150
IYARYGIDAR FVGHPMADEI PYQTDRATAR TALGLPLLSP VLAVLPGSRH 200
SEISQLGNTF LEAAGQLSEH LPGLHVVIPA ANTQCKPLLA EQLSRSTLPV 250
MHSHLLDSSA RTAMLAADVV LVASGTATLE AMLLKRPMVV AYKVAPLTYR 300
IVKTLKLLKI NRFALPNILA GEDLAPELIQ KDCTAPALCA ALLHWFKHPQ 350
KVTALQNRYL QLHTQLRRNA STRAAEAIAE LLQQR 385
Length:385
Mass (Da):42,674
Last modified:April 8, 2008 - v1
Checksum:i4B515510A9C24FC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000941 Genomic DNA. Translation: ACA11370.1.
RefSeqiYP_001775000.1. NC_010513.1.

Genome annotation databases

EnsemblBacteriaiACA11370; ACA11370; Xfasm12_0353.
GeneIDi6119560.
KEGGixfm:Xfasm12_0353.
PATRICi24136954. VBIXylFas124301_0441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000941 Genomic DNA. Translation: ACA11370.1 .
RefSeqi YP_001775000.1. NC_010513.1.

3D structure databases

ProteinModelPortali B0U236.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405440.Xfasm12_0353.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA11370 ; ACA11370 ; Xfasm12_0353 .
GeneIDi 6119560.
KEGGi xfm:Xfasm12_0353.
PATRICi 24136954. VBIXylFas124301_0441.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci XFAS405440:GH0D-371-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequences of two Xylella fastidiosa strains (M12 and M23) causing almond leaf scorch disease in California."
    Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.
    J. Bacteriol. 192:4534-4534(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M12.

Entry informationi

Entry nameiLPXB_XYLFM
AccessioniPrimary (citable) accession number: B0U236
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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