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B0U1H6 (SPEA_XYLFM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:Xfasm12_0121
OrganismXylella fastidiosa (strain M12) [Complete proteome] [HAMAP]
Taxonomic identifier405440 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 628628Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000145606

Regions

Region279 – 28911Substrate-binding Potential

Amino acid modifications

Modified residue991N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B0U1H6 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: F58400CD97519E3B

FASTA62869,330
        10         20         30         40         50         60 
MTWSQDLAHK TYSIRHWADG YFEVNDAGHM VVMPLGGDGV RISLPEVVDA ARAAGAKLPL 

        70         80         90        100        110        120 
LLRFPDILRH RLGKLQAAFV QAQSEWEYAG GYTAVYPIKV NQHRGVAGVL ASHQGDGFGL 

       130        140        150        160        170        180 
EAGSKPELMA VLALSRQGGL IVCNGYKDRE YIRLALIGRK LGLKTFIVIE KPSELRMVLE 

       190        200        210        220        230        240 
EAKTLGVLPG LGVRVRLASL GAGKWQNSGG DKAKFGLSPR QVLDVWKVLR GTEYADCLNV 

       250        260        270        280        290        300 
MHFHMGSQIS NVRDIAKGMR EATRYFVELS RLGAKITHVD VGGGLGIDYE GTRSRSDCSI 

       310        320        330        340        350        360 
NYGLQAYASH IVQPLASACE DYDLVPPRIV TECGRAMTAH HAVLIANVTE VEAVPEGRVP 

       370        380        390        400        410        420 
GLCDDEPAVV RHMREIYGEL DARPAIELFY EAQHFHAEGL AAYTLGQIDL VHRARIDDLF 

       430        440        450        460        470        480 
YAISHGVRER LSHEEKSHRP VLDELNERLV DKYFVNFSVF ESIPDVWAIN QIFPIVPIER 

       490        500        510        520        530        540 
LNEAPTRRGV VCDLTCDSDG TVKQYVENES LDSALPLHVL RHGEAYRIGF FLVGAYQEIL 

       550        560        570        580        590        600 
GDIHNLFGDT DAVEVAVDGR GYRIAQQRCG DTTDVMLDYV GYALDEVRRV YAQRITAAGM 

       610        620 
SAAESKALSD MLEAGLTGYP YLSDVPLE 

« Hide

References

[1]"Whole genome sequences of two Xylella fastidiosa strains (M12 and M23) causing almond leaf scorch disease in California."
Chen J., Xie G., Han S., Chertkov O., Sims D., Civerolo E.L.
J. Bacteriol. 192:4534-4534(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: M12.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000941 Genomic DNA. Translation: ACA11160.1.
RefSeqYP_001774790.1. NC_010513.1.

3D structure databases

ProteinModelPortalB0U1H6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405440.Xfasm12_0121.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA11160; ACA11160; Xfasm12_0121.
GeneID6119832.
KEGGxfm:Xfasm12_0121.
PATRIC24136354. VBIXylFas124301_0152.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAMIHFHIG.
OrthoDBEOG676Z0R.
ProtClustDBPRK05354.

Enzyme and pathway databases

BioCycXFAS405440:GH0D-129-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_XYLFM
AccessionPrimary (citable) accession number: B0U1H6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways