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Protein

Glutathione synthetase

Gene

gshB

Organism
Francisella philomiragia subsp. philomiragia (strain ATCC 25017)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.UniRule annotation

Pathwayi: glutathione biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes glutathione from L-cysteine and L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate--cysteine ligase (gshA)
  2. Glutathione synthetase (gshB)
This subpathway is part of the pathway glutathione biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glutathione from L-cysteine and L-glutamate, the pathway glutathione biosynthesis and in Sulfur metabolism.

GO - Molecular functioni

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processGlutathione biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00142; UER00210

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione synthetaseUniRule annotation (EC:6.3.2.3UniRule annotation)
Alternative name(s):
GSH synthetaseUniRule annotation
Short name:
GSH-SUniRule annotation
Short name:
GSHaseUniRule annotation
Glutathione synthaseUniRule annotation
Gene namesi
Name:gshBUniRule annotation
Ordered Locus Names:Fphi_1813Imported
OrganismiFrancisella philomiragia subsp. philomiragia (strain ATCC 25017)Imported
Taxonomic identifieri484022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000001320 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi484022.Fphi_1813

Structurei

3D structure databases

ProteinModelPortaliB0U0T7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 310ATP-graspInterPro annotationAdd BLAST186

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili245 – 265Sequence analysisAdd BLAST21
Coiled coili299 – 319Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the prokaryotic GSH synthase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105D7Z Bacteria
COG0189 LUCA
HOGENOMiHOG000265022
KOiK01920
OMAiWMRKDPP
OrthoDBiPOG091H04J6

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00162 GSH_S, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR006284 Glut_synth_pro
IPR004218 GSHS_ATP-bd
IPR004215 GSHS_N
IPR016185 PreATP-grasp_dom_sf
PANTHERiPTHR21621:SF4 PTHR21621:SF4, 1 hit
PfamiView protein in Pfam
PF02955 GSH-S_ATP, 1 hit
PF02951 GSH-S_N, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01380 glut_syn, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit

Sequencei

Sequence statusi: Complete.

B0U0T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVGFIIDNL NSFNISKDST YMMLQAAQDK GWEIYTFYLN DLSIINGKPK
60 70 80 90 100
GDALKIKIHK AKESWYEILS QHHDLSLLDL DCIFMRKDPP FNMEYIYVTY
110 120 130 140 150
MLDLAKKHGV LIINNPQALR DFNEKVAISN YPKFAPNTLI TRSYKQINQF
160 170 180 190 200
YAEHKDIIVK PLDGMGGSSI FRIKDGDKNK NVILETLTHH ETRYIMVQDY
210 220 230 240 250
QEAIKDGDKR ILIVNGEPIK YLLARVPSDS DNRGNLAAGA RAEVRELQEQ
260 270 280 290 300
DYKIAKKVAK KLKKEGVMFA GLDVIGDKLT EVNITSPTGI QEIYKATKVN
310 320
AASLLMQAVE KKINKMRQEQ EHGE
Length:324
Mass (Da):37,048
Last modified:April 8, 2008 - v1
Checksum:i6EA984E0A431C408
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000937 Genomic DNA Translation: ABZ88040.1
RefSeqiWP_012281090.1, NC_010336.1

Genome annotation databases

EnsemblBacteriaiABZ88040; ABZ88040; Fphi_1813
GeneIDi29664498
KEGGifph:Fphi_1813

Similar proteinsi

Entry informationi

Entry nameiB0U0T7_FRAP2
AccessioniPrimary (citable) accession number: B0U0T7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health