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B0U0T7 (B0U0T7_FRAP2) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutathione synthetase HAMAP-Rule MF_00162

EC=6.3.2.3 HAMAP-Rule MF_00162
Alternative name(s):
GSH synthetase HAMAP-Rule MF_00162
Glutathione synthase HAMAP-Rule MF_00162
Gene names
Name:gshB HAMAP-Rule MF_00162
Ordered Locus Names:Fphi_1813 EMBL ABZ88040.1
OrganismFrancisella philomiragia subsp. philomiragia (strain ATCC 25017) [Complete proteome] [HAMAP] EMBL ABZ88040.1
Taxonomic identifier484022 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione. HAMAP-Rule MF_00162

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. HAMAP-Rule MF_00162

Pathway

Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. HAMAP-Rule MF_00162

Sequence similarities

Belongs to the prokaryotic GSH synthase family. HAMAP-Rule MF_00162

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00162

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain125 – 310186ATP-grasp By similarity HAMAP-Rule MF_00162
Nucleotide binding151 – 20757ATP By similarity HAMAP-Rule MF_00162

Sites

Metal binding2811Magnesium or manganese By similarity HAMAP-Rule MF_00162
Metal binding2831Magnesium or manganese By similarity HAMAP-Rule MF_00162

Sequences

Sequence LengthMass (Da)Tools
B0U0T7 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 6EA984E0A431C408

FASTA32437,048
        10         20         30         40         50         60 
MKVGFIIDNL NSFNISKDST YMMLQAAQDK GWEIYTFYLN DLSIINGKPK GDALKIKIHK 

        70         80         90        100        110        120 
AKESWYEILS QHHDLSLLDL DCIFMRKDPP FNMEYIYVTY MLDLAKKHGV LIINNPQALR 

       130        140        150        160        170        180 
DFNEKVAISN YPKFAPNTLI TRSYKQINQF YAEHKDIIVK PLDGMGGSSI FRIKDGDKNK 

       190        200        210        220        230        240 
NVILETLTHH ETRYIMVQDY QEAIKDGDKR ILIVNGEPIK YLLARVPSDS DNRGNLAAGA 

       250        260        270        280        290        300 
RAEVRELQEQ DYKIAKKVAK KLKKEGVMFA GLDVIGDKLT EVNITSPTGI QEIYKATKVN 

       310        320 
AASLLMQAVE KKINKMRQEQ EHGE 

« Hide

References

[1]"Complete sequence of chromosome of Francisella philomiragia subsp. philomiragia ATCC 25017."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Richardson P.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 25017.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000937 Genomic DNA. Translation: ABZ88040.1.
RefSeqYP_001678541.1. NC_010336.1.

3D structure databases

ProteinModelPortalB0U0T7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING484022.Fphi_1813.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABZ88040; ABZ88040; Fphi_1813.
GeneID5908984.
KEGGfph:Fphi_1813.
PATRIC17940619. VBIFraPhi43880_1877.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0189.
HOGENOMHOG000265022.
KOK01920.
OMAPTCFQEI.
OrthoDBEOG6WMHWB.
ProtClustDBPRK05246.

Enzyme and pathway databases

BioCycFPHI484022:GHVB-1867-MONOMER.
UniPathwayUPA00142; UER00210.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00162. GSH_S.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006284. Glut_synth_pro.
IPR004218. GSHS_ATP-bd.
IPR004215. GSHS_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamPF02955. GSH-S_ATP. 1 hit.
PF02951. GSH-S_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01380. glut_syn. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB0U0T7_FRAP2
AccessionPrimary (citable) accession number: B0U0T7
Entry history
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)