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B0U0E8

- SYL_FRAP2

UniProt

B0U0E8 - SYL_FRAP2

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Francisella philomiragia subsp. philomiragia (strain ATCC 25017)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei578 – 5781ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciFPHI484022:GHVB-1805-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Fphi_1752
    OrganismiFrancisella philomiragia subsp. philomiragia (strain ATCC 25017)
    Taxonomic identifieri484022 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000001320: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 813813Leucine--tRNA ligasePRO_1000074834Add
    BLAST

    Proteomic databases

    PRIDEiB0U0E8.

    Interactioni

    Protein-protein interaction databases

    STRINGi484022.Fphi_1752.

    Structurei

    3D structure databases

    ProteinModelPortaliB0U0E8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5111"HIGH" regionAdd
    BLAST
    Motifi575 – 5795"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiMAFAGPP.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0U0E8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEYNFTQIE QQAQEYWREN NSFKAVEDKN KEKFYCLSML PYPSGTLHMG    50
    HVRNYTIGDV IARYQKMQGK NVLHPMGWDA FGLPAENAAI KHKKSPYEWT 100
    KSNIAYMRSQ LDSLGFSFDW SREVATCDES YYKWEQWFFI QLYKKGLAYR 150
    KNSVVNWDPV DQTVLANEQV VDGRGWRSGA LIEKKEIPQW FLKITDYADE 200
    LLKDINQLDG WPEAVKTMQT NWIGKSKGLT VKFKIQNSDK EIEVFTTRPD 250
    TLMGVSYLGI APEHPLALEE AKTNSQLKSF IDECKRISTM EADLATQEKK 300
    GFKTSIQAIH PISGETVNVW VANFVLMGYG SGAVMSVPAH DQRDWEFAQK 350
    YNIALKQVIK PSDNKSKLDL DKEAFTEKGI LINSGEFDGL NFKSAYQAIK 400
    KYLFDNDKGY ETTNFRIHDW GISRQRYWGC PIPMIHCNDC GLVPEKEENL 450
    PVKLPTNVTL TEAGSPLKDI PEFLNVACPN CGKPATRETD TFDTFFESSW 500
    YYARYTCPTA DKMLSEEANY WLPVDKYIGG IEHAIMHLLY ARFFHKLMRD 550
    QGLVTSDEPF KNLLTQGMVL KDGAKMSKSK GNTVDPQELI DKYGADTVRL 600
    FSMFAAPPEQ SLEWSDTGVD GANKFLRKVY NYAYTNKEIL AKNITIDVTK 650
    LSKNDKKARY EIYANLKQAI FDFDKSQFNT VVSACMKILN TLNNYDNLSD 700
    SVKLEGFSIL LRILSPFTPH ICHYLWQEIG LGEDILHTQF PTVDDIALEK 750
    DEFLLVVQIN GKVKVKLELD ASLTKEQVEQ EVLSDEQIKT FIKDKQIVKV 800
    IYVPQKLINI VVK 813
    Length:813
    Mass (Da):93,274
    Last modified:April 8, 2008 - v1
    Checksum:i1BEAB571428237E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000937 Genomic DNA. Translation: ABZ87978.1.
    RefSeqiYP_001678479.1. NC_010336.1.

    Genome annotation databases

    EnsemblBacteriaiABZ87978; ABZ87978; Fphi_1752.
    GeneIDi5908117.
    KEGGifph:Fphi_1752.
    PATRICi17940495. VBIFraPhi43880_1815.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000937 Genomic DNA. Translation: ABZ87978.1 .
    RefSeqi YP_001678479.1. NC_010336.1.

    3D structure databases

    ProteinModelPortali B0U0E8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 484022.Fphi_1752.

    Proteomic databases

    PRIDEi B0U0E8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ87978 ; ABZ87978 ; Fphi_1752 .
    GeneIDi 5908117.
    KEGGi fph:Fphi_1752.
    PATRICi 17940495. VBIFraPhi43880_1815.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi MAFAGPP.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci FPHI484022:GHVB-1805-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Francisella philomiragia subsp. philomiragia ATCC 25017."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Richardson P.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25017.

    Entry informationi

    Entry nameiSYL_FRAP2
    AccessioniPrimary (citable) accession number: B0U0E8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3