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B0U0E8

- SYL_FRAP2

UniProt

B0U0E8 - SYL_FRAP2

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Protein
Leucine--tRNA ligase
Gene
leuS, Fphi_1752
Organism
Francisella philomiragia subsp. philomiragia (strain ATCC 25017)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei578 – 5781ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciFPHI484022:GHVB-1805-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Fphi_1752
OrganismiFrancisella philomiragia subsp. philomiragia (strain ATCC 25017)
Taxonomic identifieri484022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001320: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 813813Leucine--tRNA ligaseUniRule annotation
PRO_1000074834Add
BLAST

Proteomic databases

PRIDEiB0U0E8.

Interactioni

Protein-protein interaction databases

STRINGi484022.Fphi_1752.

Structurei

3D structure databases

ProteinModelPortaliB0U0E8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionUniRule annotation
Add
BLAST
Motifi575 – 5795"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0U0E8-1 [UniParc]FASTAAdd to Basket

« Hide

MSEYNFTQIE QQAQEYWREN NSFKAVEDKN KEKFYCLSML PYPSGTLHMG    50
HVRNYTIGDV IARYQKMQGK NVLHPMGWDA FGLPAENAAI KHKKSPYEWT 100
KSNIAYMRSQ LDSLGFSFDW SREVATCDES YYKWEQWFFI QLYKKGLAYR 150
KNSVVNWDPV DQTVLANEQV VDGRGWRSGA LIEKKEIPQW FLKITDYADE 200
LLKDINQLDG WPEAVKTMQT NWIGKSKGLT VKFKIQNSDK EIEVFTTRPD 250
TLMGVSYLGI APEHPLALEE AKTNSQLKSF IDECKRISTM EADLATQEKK 300
GFKTSIQAIH PISGETVNVW VANFVLMGYG SGAVMSVPAH DQRDWEFAQK 350
YNIALKQVIK PSDNKSKLDL DKEAFTEKGI LINSGEFDGL NFKSAYQAIK 400
KYLFDNDKGY ETTNFRIHDW GISRQRYWGC PIPMIHCNDC GLVPEKEENL 450
PVKLPTNVTL TEAGSPLKDI PEFLNVACPN CGKPATRETD TFDTFFESSW 500
YYARYTCPTA DKMLSEEANY WLPVDKYIGG IEHAIMHLLY ARFFHKLMRD 550
QGLVTSDEPF KNLLTQGMVL KDGAKMSKSK GNTVDPQELI DKYGADTVRL 600
FSMFAAPPEQ SLEWSDTGVD GANKFLRKVY NYAYTNKEIL AKNITIDVTK 650
LSKNDKKARY EIYANLKQAI FDFDKSQFNT VVSACMKILN TLNNYDNLSD 700
SVKLEGFSIL LRILSPFTPH ICHYLWQEIG LGEDILHTQF PTVDDIALEK 750
DEFLLVVQIN GKVKVKLELD ASLTKEQVEQ EVLSDEQIKT FIKDKQIVKV 800
IYVPQKLINI VVK 813
Length:813
Mass (Da):93,274
Last modified:April 8, 2008 - v1
Checksum:i1BEAB571428237E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000937 Genomic DNA. Translation: ABZ87978.1.
RefSeqiYP_001678479.1. NC_010336.1.

Genome annotation databases

EnsemblBacteriaiABZ87978; ABZ87978; Fphi_1752.
GeneIDi5908117.
KEGGifph:Fphi_1752.
PATRICi17940495. VBIFraPhi43880_1815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000937 Genomic DNA. Translation: ABZ87978.1 .
RefSeqi YP_001678479.1. NC_010336.1.

3D structure databases

ProteinModelPortali B0U0E8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 484022.Fphi_1752.

Proteomic databases

PRIDEi B0U0E8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ87978 ; ABZ87978 ; Fphi_1752 .
GeneIDi 5908117.
KEGGi fph:Fphi_1752.
PATRICi 17940495. VBIFraPhi43880_1815.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci FPHI484022:GHVB-1805-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Francisella philomiragia subsp. philomiragia ATCC 25017."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Richardson P.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25017.

Entry informationi

Entry nameiSYL_FRAP2
AccessioniPrimary (citable) accession number: B0U0E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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