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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Francisella philomiragia subsp. philomiragia (strain ATCC 25017)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Fphi_0338
OrganismiFrancisella philomiragia subsp. philomiragia (strain ATCC 25017)
Taxonomic identifieri484022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000001320 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000832211 – 455Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST455

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi484022.Fphi_0338

Structurei

3D structure databases

ProteinModelPortaliB0TZJ6
SMRiB0TZJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B0TZJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFIPHKPEQ IEKMLGTIGA SSIDQLFDEI PAHLRADTLK IKDGINEIQL
60 70 80 90 100
ANQMRKRANR NHHNTNFIGA GAYSHHIPAA IWDIVARGEF YTAYTPYQAE
110 120 130 140 150
ASQGGLQVIY EFQTMMAGLT GMDASNASMY DGATALAESV LMAIRSNKKA
160 170 180 190 200
KSQKILIAEA LHPTYLRVLE TITKHQGIEF DIVNLDSKNG KTDITKLEDF
210 220 230 240 250
ANTDYAAVVI QSPNFLGQLA DVDGITNWAH KHGALVIAVT NPMSLAILKS
260 270 280 290 300
PAEWGENGAD IVCGEGQPMG VPLASGGPYF GFMTCKMAHV RQMPGRIVGR
310 320 330 340 350
TVDLDGNEGF CLTLQAREQH IRRAKATSNI CTNQGLMVTA ATIYMSLLGA
360 370 380 390 400
KGLERVASIS HENTTKLANE LSKLDGVNAR FNNVSFNEVV IDLPVNAEIF
410 420 430 440 450
VTEMEKEGID AGYFLGEYHS DLDNSIMVCA TEIHTSEDIK EYIEATKKVL

ARIGG
Length:455
Mass (Da):49,664
Last modified:April 8, 2008 - v1
Checksum:iDE1E0C9E5C1DD1FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000937 Genomic DNA Translation: ABZ86555.1
RefSeqiWP_012279838.1, NC_010336.1

Genome annotation databases

EnsemblBacteriaiABZ86555; ABZ86555; Fphi_0338
GeneIDi29665344
KEGGifph:Fphi_0338

Similar proteinsi

Entry informationi

Entry nameiGCSPA_FRAP2
AccessioniPrimary (citable) accession number: B0TZJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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