B0TZJ6 (GCSPA_FRAP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glycine dehydrogenase [decarboxylating] subunit 1
EC=1.4.4.2

Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	Fphi_0338

Organism

Francisella philomiragia subsp. philomiragia (strain ATCC 25017) [Complete proteome] [HAMAP]

Taxonomic identifier

484022 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP MF_00712
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the GcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000083221

Sequences

	Sequence		Length	Mass (Da)
	B0TZJ6 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: DE1E0C9E5C1DD1FD	FASTA	455	49,664
	10 20 30 40 50 60 MSFIPHKPEQ IEKMLGTIGA SSIDQLFDEI PAHLRADTLK IKDGINEIQL ANQMRKRANR 70 80 90 100 110 120 NHHNTNFIGA GAYSHHIPAA IWDIVARGEF YTAYTPYQAE ASQGGLQVIY EFQTMMAGLT 130 140 150 160 170 180 GMDASNASMY DGATALAESV LMAIRSNKKA KSQKILIAEA LHPTYLRVLE TITKHQGIEF 190 200 210 220 230 240 DIVNLDSKNG KTDITKLEDF ANTDYAAVVI QSPNFLGQLA DVDGITNWAH KHGALVIAVT 250 260 270 280 290 300 NPMSLAILKS PAEWGENGAD IVCGEGQPMG VPLASGGPYF GFMTCKMAHV RQMPGRIVGR 310 320 330 340 350 360 TVDLDGNEGF CLTLQAREQH IRRAKATSNI CTNQGLMVTA ATIYMSLLGA KGLERVASIS 370 380 390 400 410 420 HENTTKLANE LSKLDGVNAR FNNVSFNEVV IDLPVNAEIF VTEMEKEGID AGYFLGEYHS 430 440 450 DLDNSIMVCA TEIHTSEDIK EYIEATKKVL ARIGG

References

[1]

"Complete sequence of chromosome of Francisella philomiragia subsp. philomiragia ATCC 25017." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Richardson P. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25017.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000937 Genomic DNA. Translation: ABZ86555.1.
RefSeq	YP_001677056.1. NC_010336.1.
3D structure databases
ProteinModelPortal	B0TZJ6.
ModBase	Search...
Protein-protein interaction databases
STRING	B0TZJ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5907508.
GenomeReviews	Gene locus Fphi_0338 in contig CP000937_GR.
KEGG	fph:Fphi_0338.
PATRIC	17937477. VBIFraPhi43880_0348.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG288345.
OMA	VANASMY.
ProtClustDB	PRK00451.
Enzyme and pathway databases
BioCyc	FPHI484022:FPHI_0338-MONOMER.
Family and domain databases
HAMAP	MF_00712. GcvPA. [Tree]
InterPro	IPR020580. GDC-P_N. IPR020581. GDC_P. IPR023010. GDC_P_su1. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00282.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCSPA_FRAP2

Accession

Primary (citable) accession number: B0TZJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program