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B0TZ61

- B0TZ61_FRAP2

UniProt

B0TZ61 - B0TZ61_FRAP2

Protein

Delta-aminolevulinic acid dehydratase

Gene

Fphi_0284

Organism
Francisella philomiragia subsp. philomiragia (strain ATCC 25017)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 5-aminolevulinate = porphobilinogen + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201Zinc; catalyticUniRule annotation
    Metal bindingi122 – 1221Zinc; catalyticUniRule annotation
    Metal bindingi130 – 1301Zinc; catalyticUniRule annotation
    Active sitei196 – 1961Schiff-base intermediate with substrateUniRule annotation
    Binding sitei206 – 2061Substrate 1UniRule annotation
    Binding sitei217 – 2171Substrate 1UniRule annotation
    Metal bindingi233 – 2331MagnesiumUniRule annotation
    Active sitei248 – 2481Schiff-base intermediate with substrateUniRule annotation
    Binding sitei274 – 2741Substrate 2UniRule annotation
    Binding sitei313 – 3131Substrate 2UniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. porphobilinogen synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    LyaseUniRule annotationImported

    Keywords - Biological processi

    Porphyrin biosynthesisUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

    Enzyme and pathway databases

    BioCyciFPHI484022:GHVB-282-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
    Gene namesi
    Ordered Locus Names:Fphi_0284Imported
    OrganismiFrancisella philomiragia subsp. philomiragia (strain ATCC 25017)Imported
    Taxonomic identifieri484022 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000001320: Chromosome

    Interactioni

    Subunit structurei

    Homooctamer.UniRule annotation

    Protein-protein interaction databases

    STRINGi484022.Fphi_0284.

    Structurei

    3D structure databases

    ProteinModelPortaliB0TZ61.
    SMRiB0TZ61. Positions 5-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ALADH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0113.
    HOGENOMiHOG000020323.
    KOiK01698.
    OMAiQINPANS.
    OrthoDBiEOG6VXFCB.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view]
    PANTHERiPTHR11458. PTHR11458. 1 hit.
    PfamiPF00490. ALAD. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSiPR00144. DALDHYDRTASE.
    SMARTiSM01004. ALAD. 1 hit.
    [Graphical view]
    PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0TZ61-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFPISRPRR LRVTQAFRDM VAETKLNIDD LMYPIFVVHG NGIKKEISSM    50
    PNQYHWSVDM LDELVEQVIK LGIKSLMIFG VPKTKDLISS ENYDPNGITQ 100
    QAIRKIKQLA PELVVATDVC MCSFTPHGHC GILDEHDYVD NDRTLEILQK 150
    TAISHAQAGA DIVAPSGMMD GMIIAMRQAL DESGFETVSI MSYSVKYASA 200
    YYGPFRSACS SSLKGDRKTY QMDYRNKKEA IREALADVEQ GADFIMVKPA 250
    LSYLDIINEL SHIIELPIAA YHVSGEYAMI KAAANAGLVD EKAITIETLT 300
    SMKRAGAKII LTYTALDVAN WIR 323
    Length:323
    Mass (Da):35,954
    Last modified:April 8, 2008 - v1
    Checksum:iF39BB6087F765C68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000937 Genomic DNA. Translation: ABZ86500.1.
    RefSeqiWP_012279790.1. NC_010336.1.
    YP_001677001.1. NC_010336.1.

    Genome annotation databases

    EnsemblBacteriaiABZ86500; ABZ86500; Fphi_0284.
    GeneIDi5908104.
    KEGGifph:Fphi_0284.
    PATRICi17937367. VBIFraPhi43880_0293.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000937 Genomic DNA. Translation: ABZ86500.1 .
    RefSeqi WP_012279790.1. NC_010336.1.
    YP_001677001.1. NC_010336.1.

    3D structure databases

    ProteinModelPortali B0TZ61.
    SMRi B0TZ61. Positions 5-320.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 484022.Fphi_0284.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ86500 ; ABZ86500 ; Fphi_0284 .
    GeneIDi 5908104.
    KEGGi fph:Fphi_0284.
    PATRICi 17937367. VBIFraPhi43880_0293.

    Phylogenomic databases

    eggNOGi COG0113.
    HOGENOMi HOG000020323.
    KOi K01698.
    OMAi QINPANS.
    OrthoDBi EOG6VXFCB.

    Enzyme and pathway databases

    BioCyci FPHI484022:GHVB-282-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR001731. Porphobilinogen_synth.
    [Graphical view ]
    PANTHERi PTHR11458. PTHR11458. 1 hit.
    Pfami PF00490. ALAD. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
    PRINTSi PR00144. DALDHYDRTASE.
    SMARTi SM01004. ALAD. 1 hit.
    [Graphical view ]
    PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Francisella philomiragia subsp. philomiragia ATCC 25017."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Richardson P.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25017Imported.

    Entry informationi

    Entry nameiB0TZ61_FRAP2
    AccessioniPrimary (citable) accession number: B0TZ61
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3