SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B0TZ61

- B0TZ61_FRAP2

UniProt

B0TZ61 - B0TZ61_FRAP2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Delta-aminolevulinic acid dehydratase
Gene
Fphi_0284
Organism
Francisella philomiragia subsp. philomiragia (strain ATCC 25017)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2 5-aminolevulinate = porphobilinogen + 2 H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201Zinc; catalytic By similarityUniRule annotation
Metal bindingi122 – 1221Zinc; catalytic By similarityUniRule annotation
Metal bindingi130 – 1301Zinc; catalytic By similarityUniRule annotation
Active sitei196 – 1961Schiff-base intermediate with substrate By similarityUniRule annotation
Binding sitei206 – 2061Substrate 1 By similarity
Binding sitei217 – 2171Substrate 1 By similarity
Metal bindingi233 – 2331Magnesium By similarityUniRule annotation
Active sitei248 – 2481Schiff-base intermediate with substrate By similarityUniRule annotation
Binding sitei274 – 2741Substrate 2 By similarity
Binding sitei313 – 3131Substrate 2 By similarityUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. porphobilinogen synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciFPHI484022:GHVB-282-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-aminolevulinic acid dehydrataseUniRule annotation (EC:4.2.1.24UniRule annotation)
Gene namesi
Ordered Locus Names:Fphi_0284Imported
OrganismiFrancisella philomiragia subsp. philomiragia (strain ATCC 25017)Imported
Taxonomic identifieri484022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001320: Chromosome

Interactioni

Subunit structurei

Homooctamer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi484022.Fphi_0284.

Structurei

3D structure databases

ProteinModelPortaliB0TZ61.
SMRiB0TZ61. Positions 5-320.

Family & Domainsi

Sequence similaritiesi

Belongs to the ALADH family.

Phylogenomic databases

eggNOGiCOG0113.
HOGENOMiHOG000020323.
KOiK01698.
OMAiQINPANS.
OrthoDBiEOG6VXFCB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
PANTHERiPTHR11458. PTHR11458. 1 hit.
PfamiPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFiPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSiPR00144. DALDHYDRTASE.
SMARTiSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEiPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0TZ61-1 [UniParc]FASTAAdd to Basket

« Hide

MSFPISRPRR LRVTQAFRDM VAETKLNIDD LMYPIFVVHG NGIKKEISSM    50
PNQYHWSVDM LDELVEQVIK LGIKSLMIFG VPKTKDLISS ENYDPNGITQ 100
QAIRKIKQLA PELVVATDVC MCSFTPHGHC GILDEHDYVD NDRTLEILQK 150
TAISHAQAGA DIVAPSGMMD GMIIAMRQAL DESGFETVSI MSYSVKYASA 200
YYGPFRSACS SSLKGDRKTY QMDYRNKKEA IREALADVEQ GADFIMVKPA 250
LSYLDIINEL SHIIELPIAA YHVSGEYAMI KAAANAGLVD EKAITIETLT 300
SMKRAGAKII LTYTALDVAN WIR 323
Length:323
Mass (Da):35,954
Last modified:April 8, 2008 - v1
Checksum:iF39BB6087F765C68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000937 Genomic DNA. Translation: ABZ86500.1.
RefSeqiWP_012279790.1. NC_010336.1.
YP_001677001.1. NC_010336.1.

Genome annotation databases

EnsemblBacteriaiABZ86500; ABZ86500; Fphi_0284.
GeneIDi5908104.
KEGGifph:Fphi_0284.
PATRICi17937367. VBIFraPhi43880_0293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000937 Genomic DNA. Translation: ABZ86500.1 .
RefSeqi WP_012279790.1. NC_010336.1.
YP_001677001.1. NC_010336.1.

3D structure databases

ProteinModelPortali B0TZ61.
SMRi B0TZ61. Positions 5-320.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 484022.Fphi_0284.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ86500 ; ABZ86500 ; Fphi_0284 .
GeneIDi 5908104.
KEGGi fph:Fphi_0284.
PATRICi 17937367. VBIFraPhi43880_0293.

Phylogenomic databases

eggNOGi COG0113.
HOGENOMi HOG000020323.
KOi K01698.
OMAi QINPANS.
OrthoDBi EOG6VXFCB.

Enzyme and pathway databases

BioCyci FPHI484022:GHVB-282-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view ]
PANTHERi PTHR11458. PTHR11458. 1 hit.
Pfami PF00490. ALAD. 1 hit.
[Graphical view ]
PIRSFi PIRSF001415. Porphbilin_synth. 1 hit.
PRINTSi PR00144. DALDHYDRTASE.
SMARTi SM01004. ALAD. 1 hit.
[Graphical view ]
PROSITEi PS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Francisella philomiragia subsp. philomiragia ATCC 25017."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Richardson P.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25017.

Entry informationi

Entry nameiB0TZ61_FRAP2
AccessioniPrimary (citable) accession number: B0TZ61
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi