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B0TZ54

- RSMA_FRAP2

UniProt

B0TZ54 - RSMA_FRAP2

Protein

Ribosomal RNA small subunit methyltransferase A

Gene

rsmA

Organism
Francisella philomiragia subsp. philomiragia (strain ATCC 25017)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.UniRule annotation

    Catalytic activityi

    4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei16 – 161S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
    Binding sitei41 – 411S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei62 – 621S-adenosyl-L-methionineUniRule annotation
    Binding sitei87 – 871S-adenosyl-L-methionineUniRule annotation
    Binding sitei109 – 1091S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Source: UniProtKB-EC
    2. RNA binding Source: UniProtKB-KW
    3. rRNA (adenine-N6,N6-)-dimethyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciFPHI484022:GHVB-275-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.182UniRule annotation)
    Alternative name(s):
    16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferaseUniRule annotation
    16S rRNA dimethyladenosine transferaseUniRule annotation
    16S rRNA dimethylaseUniRule annotation
    S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferaseUniRule annotation
    Gene namesi
    Name:rsmAUniRule annotation
    Synonyms:ksgAUniRule annotation
    Ordered Locus Names:Fphi_0277
    OrganismiFrancisella philomiragia subsp. philomiragia (strain ATCC 25017)
    Taxonomic identifieri484022 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000001320: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Ribosomal RNA small subunit methyltransferase APRO_1000082553Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi484022.Fphi_0277.

    Structurei

    3D structure databases

    ProteinModelPortaliB0TZ54.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0030.
    HOGENOMiHOG000227962.
    KOiK02528.
    OMAiDHVMVEI.
    OrthoDBiEOG66F08Z.

    Family and domain databases

    Gene3Di1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPiMF_00607. 16SrRNA_methyltr_A.
    InterProiIPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR11727. PTHR11727. 1 hit.
    PfamiPF00398. RrnaAD. 1 hit.
    [Graphical view]
    SMARTiSM00650. rADc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00755. ksgA. 1 hit.
    PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
    PS51689. SAM_RNA_A_N6_MT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0TZ54-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQYKTKAKKS LGQNFLQDEN IIRKIVQLAN IKKDDIVLEI GPGLGALTRY    50
    ILKCSDNVNV VEFDASVIDT LLQNCQKYGE PKVFNEDFLK FDLDIVRADS 100
    QQKLKLIGNL PYNISSPILF KVIEQSDKII DAHFMLQKEV VERIISQPNS 150
    KTYGRLSVIL QYHFDCSMIL NIPPEVFYPQ PKVDSAILRL KPKANKLVIN 200
    DYIFFENIVK QSFAQRRKTL HNNLKGILKE LDIDPNTLPV DTKLRAENLS 250
    MEDFVSLVNF LK 262
    Length:262
    Mass (Da):30,131
    Last modified:April 8, 2008 - v1
    Checksum:iAB53E14AE2B5090F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000937 Genomic DNA. Translation: ABZ86493.1.
    RefSeqiYP_001676994.1. NC_010336.1.

    Genome annotation databases

    EnsemblBacteriaiABZ86493; ABZ86493; Fphi_0277.
    GeneIDi5909013.
    KEGGifph:Fphi_0277.
    PATRICi17937353. VBIFraPhi43880_0286.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000937 Genomic DNA. Translation: ABZ86493.1 .
    RefSeqi YP_001676994.1. NC_010336.1.

    3D structure databases

    ProteinModelPortali B0TZ54.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 484022.Fphi_0277.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ86493 ; ABZ86493 ; Fphi_0277 .
    GeneIDi 5909013.
    KEGGi fph:Fphi_0277.
    PATRICi 17937353. VBIFraPhi43880_0286.

    Phylogenomic databases

    eggNOGi COG0030.
    HOGENOMi HOG000227962.
    KOi K02528.
    OMAi DHVMVEI.
    OrthoDBi EOG66F08Z.

    Enzyme and pathway databases

    BioCyci FPHI484022:GHVB-275-MONOMER.

    Family and domain databases

    Gene3Di 1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPi MF_00607. 16SrRNA_methyltr_A.
    InterProi IPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR11727. PTHR11727. 1 hit.
    Pfami PF00398. RrnaAD. 1 hit.
    [Graphical view ]
    SMARTi SM00650. rADc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00755. ksgA. 1 hit.
    PROSITEi PS01131. RRNA_A_DIMETH. 1 hit.
    PS51689. SAM_RNA_A_N6_MT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Francisella philomiragia subsp. philomiragia ATCC 25017."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Richardson P.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25017.

    Entry informationi

    Entry nameiRSMA_FRAP2
    AccessioniPrimary (citable) accession number: B0TZ54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3