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Protein

Catalase-peroxidase

Gene

katG

Organism
Francisella philomiragia subsp. philomiragia (strain ATCC 25017)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei97Transition state stabilizerUniRule annotation1
Active sitei101Proton acceptorUniRule annotation1
Metal bindingi262Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Fphi_0203
OrganismiFrancisella philomiragia subsp. philomiragia (strain ATCC 25017)
Taxonomic identifieri484022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
Proteomesi
  • UP000001320 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_500030907924 – 739Catalase-peroxidaseAdd BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki100 ↔ 221Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-247)UniRule annotation
Cross-linki221 ↔ 247Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-100)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi484022.Fphi_0203.

Structurei

3D structure databases

ProteinModelPortaliB0TYQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0TYQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKIVTALG MSGMLLAANS AIADDKNTEM ATPQSVDLSP LRNLNKLDSP
60 70 80 90 100
MGKNYDYHQS FKKLNTEELK KDMQDLLTQS QDWWPADFGN YGPFFIRLSW
110 120 130 140 150
HDAGTYRLAD GRGGANRGQQ RFSPLNSWPD NVNLDKARQL LWPIKQKYGD
160 170 180 190 200
AVSWSDLIVL AGTVSLESMG MKPIGFAFGR EDDWQGDDTN WGISPEQLMS
210 220 230 240 250
SNVKDGKLAP AYAATQMGLI YVNPEGPDGK PDIKGAASEI RQAFRAMGMT
260 270 280 290 300
DKETVALIAG GHTFGKTHGA VPEKDIKKDI GPAPDKAPIE QQGLGWHNSY
310 320 330 340 350
GTGMGDDTMG SGLEGSWTST PTFWNHDFLH NLYNLNWEKT LSPSGAHQWT
360 370 380 390 400
PTNAKPENMV PDAHKPGVKH KPIMFTTDLA LKEDDGFNKY TQEFYNNPQE
410 420 430 440 450
FKEEFAKAWF KLTHRDMGPK SRYIGPWIPE QNFIWQDPVP VADYKQVSAQ
460 470 480 490 500
DIAQLKQDII NSGLTNQQLI RTAWDSASTY RKTDYRGGSN GARIALAPEK
510 520 530 540 550
DWQMNEPAKL EVVLAKLKEI QTNFNNNKTD GTKVSLADLI VLGGNVGVEQ
560 570 580 590 600
AAKEAGYTIE IPFVPGRTDA TQAQTDIESF NYLKTKADGF VNYSDGSLAS
610 620 630 640 650
NKLPQALVEK ASMLNLNIPE MTVLVGGMRA LNVNYDDSQE GVFTKTPGQL
660 670 680 690 700
NNNFFVNLLD MSTKWEKSDT NSGEYIGIDR KTGAQKWTAT SVDLIFGSNS
710 720 730
ELKAVAQVYA ENGNEQKFVN DFAKAWHKVM MLGRFDVQE
Length:739
Mass (Da):82,097
Last modified:April 8, 2008 - v1
Checksum:iCAC0FDA50FCB170B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000937 Genomic DNA. Translation: ABZ86421.1.
RefSeqiWP_012279727.1. NC_010336.1.

Genome annotation databases

EnsemblBacteriaiABZ86421; ABZ86421; Fphi_0203.
KEGGifph:Fphi_0203.
PATRICi17937201. VBIFraPhi43880_0211.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000937 Genomic DNA. Translation: ABZ86421.1.
RefSeqiWP_012279727.1. NC_010336.1.

3D structure databases

ProteinModelPortaliB0TYQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi484022.Fphi_0203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABZ86421; ABZ86421; Fphi_0203.
KEGGifph:Fphi_0203.
PATRICi17937201. VBIFraPhi43880_0211.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_FRAP2
AccessioniPrimary (citable) accession number: B0TYQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.