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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Francisella philomiragia subsp. philomiragia (strain ATCC 25017)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei346 – 3461Proton donorUniRule annotation
Active sitei377 – 3771UniRule annotation
Active sitei505 – 5051UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciFPHI484022:GHVB-155-MONOMER.
UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:Fphi_0158
OrganismiFrancisella philomiragia subsp. philomiragia (strain ATCC 25017)
Taxonomic identifieri484022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001320: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Glucose-6-phosphate isomerasePRO_1000081239Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi484022.Fphi_0158.

Structurei

3D structure databases

ProteinModelPortaliB0TYL4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0TYL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFCNDSNKE LREQKVSLSH EFATDNHRVE KLSLKFENIY FDYSKNLVND
60 70 80 90 100
NILKTLLESA SKSNLKNKIQ QMFAGEKINS TENRSVLHTA LRDLSNSPLV
110 120 130 140 150
IDGQDIRKEV NEEKQRVKAL VEKVTSGDWK GFSGKRITDI VNIGIGGSDL
160 170 180 190 200
GPKMVVRALQ PYHCTGLKVH FVSNVDADSL LQALHVIDPE TTLFIVASKS
210 220 230 240 250
FSTEETLLNS ISAREWLLDH YEDEKAVANH FVAISSKLDK VEEFGINLEH
260 270 280 290 300
CYKMWDWVGG RYSLWSSIGM SIAFAVGYDN FEKLLAGAYS IDKHFKETEF
310 320 330 340 350
DKNIPVIMGL LASYYSCAYQ SQSQALLPYD ERLCYFVDYL QQADMESNGK
360 370 380 390 400
SVNLAGEGVD YQTGVVLWGG VGTNGQHAFH QLLHQGNVFI PVDFIAVATS
410 420 430 440 450
HHNYDNHQQA LLANCFAQSQ ALMFGQSYDM VYNELLNSGL SEVQAKQLAP
460 470 480 490 500
HKVIPGNRPS TTILLDELSP YTLGALIALY EHKIFVQGVL WDINSYDQWG
510 520 530 540
VELGKKLGKN ILKAMSDDSS AEYQNLDEST KWLIAKVKSK
Length:540
Mass (Da):60,684
Last modified:April 8, 2008 - v1
Checksum:i12D00B3375EFF550
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000937 Genomic DNA. Translation: ABZ86379.1.
RefSeqiWP_012279696.1. NC_010336.1.
YP_001676880.1. NC_010336.1.

Genome annotation databases

EnsemblBacteriaiABZ86379; ABZ86379; Fphi_0158.
GeneIDi5907399.
KEGGifph:Fphi_0158.
PATRICi17937103. VBIFraPhi43880_0164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000937 Genomic DNA. Translation: ABZ86379.1.
RefSeqiWP_012279696.1. NC_010336.1.
YP_001676880.1. NC_010336.1.

3D structure databases

ProteinModelPortaliB0TYL4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi484022.Fphi_0158.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABZ86379; ABZ86379; Fphi_0158.
GeneIDi5907399.
KEGGifph:Fphi_0158.
PATRICi17937103. VBIFraPhi43880_0164.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
UPA00138.
BioCyciFPHI484022:GHVB-155-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Francisella philomiragia subsp. philomiragia ATCC 25017."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Richardson P.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25017.

Entry informationi

Entry nameiG6PI_FRAP2
AccessioniPrimary (citable) accession number: B0TYL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: January 7, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.