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B0TXG8

- LPXB_FRAP2

UniProt

B0TXG8 - LPXB_FRAP2

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Fphi_1201
Organism
Francisella philomiragia subsp. philomiragia (strain ATCC 25017)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciFPHI484022:GHVB-1236-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Fphi_1201
OrganismiFrancisella philomiragia subsp. philomiragia (strain ATCC 25017)
Taxonomic identifieri484022 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000001320: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000080279Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi484022.Fphi_1201.

Structurei

3D structure databases

ProteinModelPortaliB0TXG8.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B0TXG8-1 [UniParc]FASTAAdd to Basket

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MRIGIVAGEL SGDQLGATLV EALKKKYPNA EIEGIGGPKM EAQGFKSLYP    50
MDALSLIGFL EILSKGLSIL NIRRKIIKYF KHNKPDIFIG IDAPDFNLTV 100
EKKLRASGIK TIHYVSPKIW VWREYRIKKI RKATDKILAI LPFEVEYYKN 150
RHNFEAIYVG HPLAKNISLE IDRSKYKKRL GLENVELPIL SVLPGSRTTE 200
VTRLLPLFLD AIEKLQESGY KFKAIMPLAK PSLKPIFDQY NSQIRSLGIE 250
VLETNSHDVL KASDLSLLAS GTATLEAMLC KLPMVVGYKL SKLSAFIGRI 300
LIRGHSYWAF PNILHKSEII KELIQEDCTV DNLFYELKRL FDDKQRNNYI 350
VQEFKKIHEH MVVDTEEKII EVLDSIIEKS 380
Length:380
Mass (Da):43,415
Last modified:April 8, 2008 - v1
Checksum:i9A695C990BAAB4CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000937 Genomic DNA. Translation: ABZ87426.1.
RefSeqiYP_001677927.1. NC_010336.1.

Genome annotation databases

EnsemblBacteriaiABZ87426; ABZ87426; Fphi_1201.
GeneIDi5908967.
KEGGifph:Fphi_1201.
PATRICi17939332. VBIFraPhi43880_1249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000937 Genomic DNA. Translation: ABZ87426.1 .
RefSeqi YP_001677927.1. NC_010336.1.

3D structure databases

ProteinModelPortali B0TXG8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 484022.Fphi_1201.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ87426 ; ABZ87426 ; Fphi_1201 .
GeneIDi 5908967.
KEGGi fph:Fphi_1201.
PATRICi 17939332. VBIFraPhi43880_1249.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci FPHI484022:GHVB-1236-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Francisella philomiragia subsp. philomiragia ATCC 25017."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Richardson P.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25017.

Entry informationi

Entry nameiLPXB_FRAP2
AccessioniPrimary (citable) accession number: B0TXG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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