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B0TVP3 (FTHS_SHEHH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Shal_3806
OrganismShewanella halifaxensis (strain HAW-EB4) [Complete proteome] [HAMAP]
Taxonomic identifier458817 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000087656

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B0TVP3 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 80790262CD6908E4

FASTA57060,793
        10         20         30         40         50         60 
MQSDIEISRQ HTCLPITEIA KDLGLNPDEF SPCGVNKAKV SQSVARRLAD KKNAKLVIVT 

        70         80         90        100        110        120 
AVTPTPFGEG KTVTTIGLTQ AMNLNGIKTC ACIRQPSMGP VFGTKGGAAG GGYAQVVPME 

       130        140        150        160        170        180 
ELNLHLTGDI HAVSSAHNLA AAAIDARLFH EHRLGAEVFA QESGLSALNI DSENILWRRV 

       190        200        210        220        230        240 
VDHNERSLRQ IKVGYGKVNG PVHESGFDIT AASELMAILA LSQDLKDLRQ RIGRLVLALN 

       250        260        270        280        290        300 
TQGEPITAEE LGVAGAMTVI MADAIEPTLM QTLSGDPCFI HAGPFANIAH GNSSIIADTI 

       310        320        330        340        350        360 
AAKLADVVIT EAGFGSDMGF EKFSNIKVRE SGYAPSASVV VVTLKALKAN SGIESDKDIN 

       370        380        390        400        410        420 
QPDMERLQAG FANLEWHINN VSQYGVPVVV AINRFPTDTD EELEWLKQAV EQTKAFGSEI 

       430        440        450        460        470        480 
SEAFGKGAEG ATKLADMVYH ATQTPSDFKL LYQSDTSLEA KLMTLAEVGY GASSVTLSDK 

       490        500        510        520        530        540 
AKSQLHWLTK HNYGQLPICV AKTPMSISHD PSIKGIPTEF ELPITELRLN AGAGFVTALV 

       550        560        570 
GQVMTMPGLG IKPGYLNVDI NDDGEIIGLA 

« Hide

References

[1]"Complete sequence of Shewanella halifaxensis HAW-EB4."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Zhao J.-S., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HAW-EB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000931 Genomic DNA. Translation: ABZ78346.1.
RefSeqYP_001676005.1. NC_010334.1.

3D structure databases

ProteinModelPortalB0TVP3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING458817.Shal_3806.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABZ78346; ABZ78346; Shal_3806.
GeneID5904001.
KEGGshl:Shal_3806.
PATRIC23510616. VBISheHal24697_3990.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13506.

Enzyme and pathway databases

BioCycSHAL458817:GH1X-3929-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFTHS_SHEHH
AccessionPrimary (citable) accession number: B0TVP3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways