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B0TVP3

- FTHS_SHEHH

UniProt

B0TVP3 - FTHS_SHEHH

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Shal_3806
Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHAL458817:GH1X-3929-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Shal_3806
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001317: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000087656Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi458817.Shal_3806.

Structurei

3D structure databases

ProteinModelPortaliB0TVP3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

B0TVP3-1 [UniParc]FASTAAdd to Basket

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MQSDIEISRQ HTCLPITEIA KDLGLNPDEF SPCGVNKAKV SQSVARRLAD    50
KKNAKLVIVT AVTPTPFGEG KTVTTIGLTQ AMNLNGIKTC ACIRQPSMGP 100
VFGTKGGAAG GGYAQVVPME ELNLHLTGDI HAVSSAHNLA AAAIDARLFH 150
EHRLGAEVFA QESGLSALNI DSENILWRRV VDHNERSLRQ IKVGYGKVNG 200
PVHESGFDIT AASELMAILA LSQDLKDLRQ RIGRLVLALN TQGEPITAEE 250
LGVAGAMTVI MADAIEPTLM QTLSGDPCFI HAGPFANIAH GNSSIIADTI 300
AAKLADVVIT EAGFGSDMGF EKFSNIKVRE SGYAPSASVV VVTLKALKAN 350
SGIESDKDIN QPDMERLQAG FANLEWHINN VSQYGVPVVV AINRFPTDTD 400
EELEWLKQAV EQTKAFGSEI SEAFGKGAEG ATKLADMVYH ATQTPSDFKL 450
LYQSDTSLEA KLMTLAEVGY GASSVTLSDK AKSQLHWLTK HNYGQLPICV 500
AKTPMSISHD PSIKGIPTEF ELPITELRLN AGAGFVTALV GQVMTMPGLG 550
IKPGYLNVDI NDDGEIIGLA 570
Length:570
Mass (Da):60,793
Last modified:April 8, 2008 - v1
Checksum:i80790262CD6908E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ78346.1.
RefSeqiWP_012278864.1. NC_010334.1.
YP_001676005.1. NC_010334.1.

Genome annotation databases

EnsemblBacteriaiABZ78346; ABZ78346; Shal_3806.
GeneIDi5904001.
KEGGishl:Shal_3806.
PATRICi23510616. VBISheHal24697_3990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ78346.1 .
RefSeqi WP_012278864.1. NC_010334.1.
YP_001676005.1. NC_010334.1.

3D structure databases

ProteinModelPortali B0TVP3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 458817.Shal_3806.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ78346 ; ABZ78346 ; Shal_3806 .
GeneIDi 5904001.
KEGGi shl:Shal_3806.
PATRICi 23510616. VBISheHal24697_3990.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SHAL458817:GH1X-3929-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB4.

Entry informationi

Entry nameiFTHS_SHEHH
AccessioniPrimary (citable) accession number: B0TVP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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