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B0TVP3

- FTHS_SHEHH

UniProt

B0TVP3 - FTHS_SHEHH

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHAL458817:GH1X-3929-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Shal_3806
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001317: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_1000087656Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi458817.Shal_3806.

Structurei

3D structure databases

ProteinModelPortaliB0TVP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

B0TVP3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSDIEISRQ HTCLPITEIA KDLGLNPDEF SPCGVNKAKV SQSVARRLAD
60 70 80 90 100
KKNAKLVIVT AVTPTPFGEG KTVTTIGLTQ AMNLNGIKTC ACIRQPSMGP
110 120 130 140 150
VFGTKGGAAG GGYAQVVPME ELNLHLTGDI HAVSSAHNLA AAAIDARLFH
160 170 180 190 200
EHRLGAEVFA QESGLSALNI DSENILWRRV VDHNERSLRQ IKVGYGKVNG
210 220 230 240 250
PVHESGFDIT AASELMAILA LSQDLKDLRQ RIGRLVLALN TQGEPITAEE
260 270 280 290 300
LGVAGAMTVI MADAIEPTLM QTLSGDPCFI HAGPFANIAH GNSSIIADTI
310 320 330 340 350
AAKLADVVIT EAGFGSDMGF EKFSNIKVRE SGYAPSASVV VVTLKALKAN
360 370 380 390 400
SGIESDKDIN QPDMERLQAG FANLEWHINN VSQYGVPVVV AINRFPTDTD
410 420 430 440 450
EELEWLKQAV EQTKAFGSEI SEAFGKGAEG ATKLADMVYH ATQTPSDFKL
460 470 480 490 500
LYQSDTSLEA KLMTLAEVGY GASSVTLSDK AKSQLHWLTK HNYGQLPICV
510 520 530 540 550
AKTPMSISHD PSIKGIPTEF ELPITELRLN AGAGFVTALV GQVMTMPGLG
560 570
IKPGYLNVDI NDDGEIIGLA
Length:570
Mass (Da):60,793
Last modified:April 8, 2008 - v1
Checksum:i80790262CD6908E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ78346.1.
RefSeqiYP_001676005.1. NC_010334.1.

Genome annotation databases

EnsemblBacteriaiABZ78346; ABZ78346; Shal_3806.
GeneIDi5904001.
KEGGishl:Shal_3806.
PATRICi23510616. VBISheHal24697_3990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ78346.1 .
RefSeqi YP_001676005.1. NC_010334.1.

3D structure databases

ProteinModelPortali B0TVP3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 458817.Shal_3806.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ78346 ; ABZ78346 ; Shal_3806 .
GeneIDi 5904001.
KEGGi shl:Shal_3806.
PATRICi 23510616. VBISheHal24697_3990.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SHAL458817:GH1X-3929-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB4.

Entry informationi

Entry nameiFTHS_SHEHH
AccessioniPrimary (citable) accession number: B0TVP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3