UniProtKB - B0TTT0 (ACDH_SHEHH)
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Protein
Acetaldehyde dehydrogenase
Gene
Shal_2089
Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Functioni
Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation
Catalytic activityi
Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 130 | Acyl-thioester intermediateUniRule annotation | 1 | |
Binding sitei | 272 | NADUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 15 | NADUniRule annotation | 4 | |
Nucleotide bindingi | 161 – 169 | NADUniRule annotation | 9 |
GO - Molecular functioni
- acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-EC
- NAD binding Source: InterPro
GO - Biological processi
- aromatic compound catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Aromatic hydrocarbons catabolism |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | SHAL458817:G1GB1-2204-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)Alternative name(s): Acetaldehyde dehydrogenase [acetylating]UniRule annotation |
Gene namesi | Ordered Locus Names:Shal_2089 |
Organismi | Shewanella halifaxensis (strain HAW-EB4) |
Taxonomic identifieri | 458817 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000387739 | 1 – 307 | Acetaldehyde dehydrogenaseAdd BLAST | 307 |
Structurei
3D structure databases
ProteinModelPortali | B0TTT0. |
SMRi | B0TTT0. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the acetaldehyde dehydrogenase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105DIV. Bacteria. COG4569. LUCA. |
HOGENOMi | HOG000052149. |
KOi | K18366. |
OMAi | IMMHNTI. |
OrthoDBi | POG091H09NP. |
Family and domain databases
HAMAPi | MF_01657. Ac_ald_DH_ac. 1 hit. |
InterProi | View protein in InterPro IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR036291. NAD(P)-bd_dom_sf. IPR000534. Semialdehyde_DH_NAD-bd. |
Pfami | View protein in Pfam PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. |
PIRSFi | PIRSF015689. Actaldh_dh_actl. 1 hit. |
SMARTi | View protein in SMART SM00859. Semialdhyde_dh. 1 hit. |
SUPFAMi | SSF51735. SSF51735. 1 hit. |
TIGRFAMsi | TIGR03215. ac_ald_DH_ac. 1 hit. |
i Sequence
Sequence statusi: Complete.
B0TTT0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSKIKCALI GSGNIGTDLL YKLMRSDVLE PVWMVGIDPE SDGLARAKAA
60 70 80 90 100
GLKVTADGIN GLLPFVEADE IKIAFDATSA YVHAENSRKL NELGVVMIDL
110 120 130 140 150
TPAAIGPFCV PPVNLSQLDE NVKNINMVTC GGQATIPMVA AVSRVQAVEY
160 170 180 190 200
GEIVATVSSR SVGPGTRQNI DEFTRTTAGA VEQIGGAEKG KAIIVINPAE
210 220 230 240 250
PPLLMRDTIH CLTKEQPDEQ AITASVHEMI EQVQQYVPGY TLKNGPVFDG
260 270 280 290 300
RKVTIFLEVE GLGDYLPKYA GNLDIMTAAA ARTAEMLASK MLNPEPHYNV
TQEAALA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000931 Genomic DNA. Translation: ABZ76648.1. |
RefSeqi | WP_012277178.1. NC_010334.1. |
Genome annotation databases
EnsemblBacteriai | ABZ76648; ABZ76648; Shal_2089. |
KEGGi | shl:Shal_2089. |
Similar proteinsi
Entry informationi
Entry namei | ACDH_SHEHH | |
Accessioni | B0TTT0Primary (citable) accession number: B0TTT0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 3, 2009 |
Last sequence update: | April 8, 2008 | |
Last modified: | February 28, 2018 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |