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Protein

Acetaldehyde dehydrogenase

Gene

Shal_2089

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei130Acyl-thioester intermediateUniRule annotation1
Binding sitei272NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADUniRule annotation4
Nucleotide bindingi161 – 169NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciSHAL458817:G1GB1-2204-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Ordered Locus Names:Shal_2089
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001317 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877391 – 307Acetaldehyde dehydrogenaseAdd BLAST307

Proteomic databases

PRIDEiB0TTT0

Interactioni

Protein-protein interaction databases

STRINGi458817.Shal_2089

Structurei

3D structure databases

ProteinModelPortaliB0TTT0
SMRiB0TTT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK18366
OMAiIMMHNTI
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

B0TTT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKIKCALI GSGNIGTDLL YKLMRSDVLE PVWMVGIDPE SDGLARAKAA
60 70 80 90 100
GLKVTADGIN GLLPFVEADE IKIAFDATSA YVHAENSRKL NELGVVMIDL
110 120 130 140 150
TPAAIGPFCV PPVNLSQLDE NVKNINMVTC GGQATIPMVA AVSRVQAVEY
160 170 180 190 200
GEIVATVSSR SVGPGTRQNI DEFTRTTAGA VEQIGGAEKG KAIIVINPAE
210 220 230 240 250
PPLLMRDTIH CLTKEQPDEQ AITASVHEMI EQVQQYVPGY TLKNGPVFDG
260 270 280 290 300
RKVTIFLEVE GLGDYLPKYA GNLDIMTAAA ARTAEMLASK MLNPEPHYNV

TQEAALA
Length:307
Mass (Da):32,766
Last modified:April 8, 2008 - v1
Checksum:i5F4724FD4A761C5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000931 Genomic DNA Translation: ABZ76648.1
RefSeqiWP_012277178.1, NC_010334.1

Genome annotation databases

EnsemblBacteriaiABZ76648; ABZ76648; Shal_2089
KEGGishl:Shal_2089

Similar proteinsi

Entry informationi

Entry nameiACDH_SHEHH
AccessioniPrimary (citable) accession number: B0TTT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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