B0TTT0 (ACDH_SHEHH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]

Gene names

Ordered Locus Names:

Shal_2089

Organism

Shewanella halifaxensis (strain HAW-EB4) [Complete proteome] [HAMAP]

Taxonomic identifier

458817 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella › Shewanella halifaxensis

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aromatic compound catabolic process Inferred from electronic annotation. Source: HAMAP cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	NAD binding Inferred from electronic annotation. Source: HAMAP acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Acetaldehyde dehydrogenase HAMAP-Rule MF_01657		PRO_0000387739
Regions
	Nucleotide binding	12 – 15	4	NAD By similarity
	Nucleotide binding	161 – 169	9	NAD By similarity
Sites
	Active site	130	1	Acyl-thioester intermediate By similarity
	Binding site	272	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0TTT0 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 5F4724FD4A761C5A	FASTA	307	32,766
	10 20 30 40 50 60 MTSKIKCALI GSGNIGTDLL YKLMRSDVLE PVWMVGIDPE SDGLARAKAA GLKVTADGIN 70 80 90 100 110 120 GLLPFVEADE IKIAFDATSA YVHAENSRKL NELGVVMIDL TPAAIGPFCV PPVNLSQLDE 130 140 150 160 170 180 NVKNINMVTC GGQATIPMVA AVSRVQAVEY GEIVATVSSR SVGPGTRQNI DEFTRTTAGA 190 200 210 220 230 240 VEQIGGAEKG KAIIVINPAE PPLLMRDTIH CLTKEQPDEQ AITASVHEMI EQVQQYVPGY 250 260 270 280 290 300 TLKNGPVFDG RKVTIFLEVE GLGDYLPKYA GNLDIMTAAA ARTAEMLASK MLNPEPHYNV TQEAALA

References

[1]

"Complete sequence of Shewanella halifaxensis HAW-EB4." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Zhao J.-S., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HAW-EB4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000931 Genomic DNA. Translation: ABZ76648.1.
RefSeq	YP_001674307.1. NC_010334.1.
3D structure databases
ProteinModelPortal	B0TTT0.
SMR	B0TTT0. Positions 1-293.
ModBase	Search...
Protein-protein interaction databases
STRING	458817.Shal_2089.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABZ76648; ABZ76648; Shal_2089.
GeneID	5902820.
KEGG	shl:Shal_2089.
PATRIC	23506949. VBISheHal24697_2196.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4569.
HOGENOM	HOG000052149.
KO	K04073.
OMA	TSAYVHK.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	SHAL458817:GH1X-2174-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01657. Ac_ald_DH_ac.
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
PANTHER	PTHR21123. PTHR21123. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH_SHEHH

Accession

Primary (citable) accession number: B0TTT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program