ID   PYRB2_SHEHH             Reviewed;         310 AA.
AC   B0TST3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   16-JUN-2009, entry version 11.
DE   RecName: Full=Aspartate carbamoyltransferase 2;
DE            EC=2.1.3.2;
DE   AltName: Full=Aspartate transcarbamylase 2;
DE            Short=ATCase 2;
GN   Name=pyrB2; OrderedLocusNames=Shal_0683;
OS   Shewanella halifaxensis (strain HAW-EB4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=458817;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella halifaxensis HAW-EB4.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC       + N-carbamoyl-L-aspartate.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from HCO(3)(-): step 2/6.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR   EMBL; CP000931; ABZ75258.1; -; Genomic_DNA.
DR   RefSeq; YP_001672917.1; -.
DR   GeneID; 5906168; -.
DR   GenomeReviews; CP000931_GR; Shal_0683.
DR   KEGG; shl:Shal_0683; -.
DR   OMA; B0TST3; LYTIREN.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00001; -; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P_bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
DR   InterPro; IPR002082; Aspartate_carbamoyltransf_euk.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Pyrimidine biosynthesis; Transferase.
FT   CHAIN         1    310       Aspartate carbamoyltransferase 2.
FT                                /FTId=PRO_0000334594.
SQ   SEQUENCE   310 AA;  34729 MW;  91D62C9AF791552C CRC64;
     MTNTIYNKNI ISISDLSRSE LELIVATANE LKQNPRPELL KNKVVASCFF EASTRTRLSF
     ETAVQRLGGS IIGFPDGGNT SLGKKGETLA DSVQVISSYC DAFFIRHNQE GAARLASEFS
     SVPVINGGDG SNQHPTQTLL DLFSIYETQG TLEKLQVAFV GDLKYGRTVH SLTQALSLFD
     CEFHFVAPKA LLMPDYIIDE LKEKGCKYTL HETLDEIMDS LDILYMTRVQ KERFDETEYQ
     HLKSSFILTA NMLKGVKDNL KILHPLPRVD EITTDVDSTP YAYYFQQAKN GVYARQALLT
     LVLTNEFGDL
//