B0TST3 (PYRB2_SHEHH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase 2
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase 2
Short name=ATCase 2

Gene names

Name:	pyrB2
Ordered Locus Names:	Shal_0683

Organism

Shewanella halifaxensis (strain HAW-EB4) [Complete proteome] [HAMAP]

Taxonomic identifier

458817 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Aspartate carbamoyltransferase 2 HAMAP MF_00001		PRO_0000334594

Sequences

	Sequence		Length	Mass (Da)
	B0TST3 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 91D62C9AF791552C	FASTA	310	34,729
	10 20 30 40 50 60 MTNTIYNKNI ISISDLSRSE LELIVATANE LKQNPRPELL KNKVVASCFF EASTRTRLSF 70 80 90 100 110 120 ETAVQRLGGS IIGFPDGGNT SLGKKGETLA DSVQVISSYC DAFFIRHNQE GAARLASEFS 130 140 150 160 170 180 SVPVINGGDG SNQHPTQTLL DLFSIYETQG TLEKLQVAFV GDLKYGRTVH SLTQALSLFD 190 200 210 220 230 240 CEFHFVAPKA LLMPDYIIDE LKEKGCKYTL HETLDEIMDS LDILYMTRVQ KERFDETEYQ 250 260 270 280 290 300 HLKSSFILTA NMLKGVKDNL KILHPLPRVD EITTDVDSTP YAYYFQQAKN GVYARQALLT 310 LVLTNEFGDL

References

[1]

"Complete sequence of Shewanella halifaxensis HAW-EB4." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Zhao J.-S., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HAW-EB4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000931 Genomic DNA. Translation: ABZ75258.1.
RefSeq	YP_001672917.1. NC_010334.1.
3D structure databases
ProteinModelPortal	B0TST3.
SMR	B0TST3. Positions 3-309.
ModBase	Search...
Protein-protein interaction databases
STRING	B0TST3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5906168.
GenomeReviews	Gene locus Shal_0683 in contig CP000931_GR.
KEGG	shl:Shal_0683.
PATRIC	23503842. VBISheHal24697_0717.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	DLYTIRQ.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	SHAL458817:SHAL_0683-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB2_SHEHH

Accession

Primary (citable) accession number: B0TST3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program