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B0TSS5 (TPMT_SHEHH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thiopurine S-methyltransferase
EC=2.1.1.67
Alternative name(s):
Thiopurine methyltransferase
Gene names
Name:tpm
Ordered Locus Names:Shal_0675
OrganismShewanella halifaxensis (strain HAW-EB4) [Complete proteome] [HAMAP]
Taxonomic identifier458817 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. HAMAP MF_00812

Subcellular location

Cytoplasm By similarity HAMAP MF_00812.

Sequence similarities

Belongs to the methyltransferase superfamily. TPMT family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthiopurine S-methyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 219219Thiopurine S-methyltransferase HAMAP MF_00812
PRO_1000083763

Sites

Binding site101S-adenosyl-L-methionine By similarity
Binding site451S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site661S-adenosyl-L-methionine By similarity
Binding site1231S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
B0TSS5 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 440B4458FAC03073

FASTA21925,139
        10         20         30         40         50         60 
MQPSFWHEKW DAQQIGFHLS AVNPLLVKYW QQLELDADSQ VFVPLCGKSL DMCFLAEQGH 

        70         80         90        100        110        120 
DVLGCELNEL AVQQFYRENA LAFDVTKLAE HQRFHTEQVT IYQGDIFSLD VAEMPSTTAF 

       130        140        150        160        170        180 
YDRAALIAWP EEMRLAYARQ LAKLIPANSV GLLITLDYPQ AELNGPPFAV SDDWVQANLS 

       190        200        210 
QDFKIERLAS EDVLRDNPRF VKKQVSWLTE SVYRLIRKG

« Hide

References

[1]"Complete sequence of Shewanella halifaxensis HAW-EB4."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Zhao J.-S., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HAW-EB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000931 Genomic DNA. Translation: ABZ75250.1.
RefSeqYP_001672909.1. NC_010334.1.

3D structure databases

ProteinModelPortalB0TSS5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0TSS5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5906647.
GenomeReviewsGene locus Shal_0675 in contig CP000931_GR.
KEGGshl:Shal_0675.
PATRIC23503826. VBISheHal24697_0710.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG444929.
OMAQGDIFTL.
ProtClustDBPRK13255.

Enzyme and pathway databases

BioCycSHAL458817:SHAL_0675-MONOMER.

Family and domain databases

HAMAPMF_00812. Thiopur_methtran.
[Tree]
InterProIPR022474. Thiopur_S-MeTfrase_Se/Te_detox.
IPR008854. Thiopurine_S-MeTrfase.
IPR016822. Thiopurine_S-MeTrfase_sub.
[Graphical view]
KOK00569.
PANTHERPTHR10259. PTHR10259. 1 hit.
PfamPF05724. TPMT. 1 hit.
[Graphical view]
PIRSFPIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
TIGRFAMsTIGR03840. TMPT_Se_Te. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTPMT_SHEHH
AccessionPrimary (citable) accession number: B0TSS5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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