ID   PYRB1_SHEHH             Reviewed;         310 AA.
AC   B0TSQ4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   16-JUN-2009, entry version 11.
DE   RecName: Full=Aspartate carbamoyltransferase 1;
DE            EC=2.1.3.2;
DE   AltName: Full=Aspartate transcarbamylase 1;
DE            Short=ATCase 1;
GN   Name=pyrB1; OrderedLocusNames=Shal_0654;
OS   Shewanella halifaxensis (strain HAW-EB4).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=458817;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E.,
RA   Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T.,
RA   Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Zhao J.-S., Richardson P.;
RT   "Complete sequence of Shewanella halifaxensis HAW-EB4.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC       + N-carbamoyl-L-aspartate.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from HCO(3)(-): step 2/6.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR   EMBL; CP000931; ABZ75229.1; -; Genomic_DNA.
DR   RefSeq; YP_001672888.1; -.
DR   GeneID; 5906714; -.
DR   GenomeReviews; CP000931_GR; Shal_0654.
DR   KEGG; shl:Shal_0654; -.
DR   OMA; B0TSQ4; RFDESEY.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00001; -; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P_bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
DR   InterPro; IPR002082; Aspartate_carbamoyltransf_euk.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Pyrimidine biosynthesis; Transferase.
FT   CHAIN         1    310       Aspartate carbamoyltransferase 1.
FT                                /FTId=PRO_0000334593.
SQ   SEQUENCE   310 AA;  34626 MW;  8E7CDFB017B9FB28 CRC64;
     MSNPLYNKNI ISITDLSRAE LELIVSTANE LKQHPRPDLL KNKVIASCFF EASTRTRLSF
     ETAVQRLGGS VIGFPDSGNT SLGKKGETLA DSVQVISSYS DAFFMRHNQE GAARLASEFS
     SVPVINGGDG SNQHPTQTLL DLFSIYETQG TLDKLQVAFV GDLKYGRTVH SLTQALSLFD
     CEFHFVAPPA LSMPEYIIDE LKEKGCTFTQ YDSLDGVLSK LDILYMTRVQ KERFDETEYQ
     HMKSSFILTA QMFEGVKDNL KVLHPLPRVD EITTDVDSTP YAYYFQQAKN GVYARQALLA
     LVLTNEFGDK
//